Journal of Biological Chemistry

A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant

Alexandra Papafotika, Maria Pavlaki, Vasiliki Lazani et al. Mar 01, 2026 pp. 111207 10.1016/j.jbc.2026.111207

The amyloidogenic C-terminal region of TMEM106B modulates lipid membrane biophysical properties: Functional and pathological insights

Mélanie Berbon, Axelle Grélard, Laure Bataille et al. Mar 01, 2026 pp. 111175 10.1016/j.jbc.2026.111175

Topologically associating domains define the 3D genome architecture of mouse totipotent-like stem cells

Yu Fu, Wenyu Ma, Jin Han et al. Mar 01, 2026 pp. 111236 10.1016/j.jbc.2026.111236

Allosteric targeting with antiviral nucleotide analogs allows fine-tuning of SAMHD1 dNTPase activity

Christopher Dirks, Ann-Kathrin Schlotterbeck, Pontus Pettersson et al. Mar 01, 2026 pp. 111214 10.1016/j.jbc.2026.111214

Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5

Huaping Qin, Lennis B. Orduña-Castillo, Olivia Molinar-Inglis et al. Mar 01, 2026 pp. 111190 10.1016/j.jbc.2026.111190

Biochemical analysis of a TrkB receptor mutation that causes a developmental epileptic encephalopathy

Yang Zhong Huang, Cormic McNamara, James O. McNamara Mar 01, 2026 pp. 111152 10.1016/j.jbc.2026.111152

Intracellular pH regulates β-catenin with low pHi increasing adhesion and signaling functions

Brandon J. Czowski, Angelina N. Marchi, Katharine A. White Mar 01, 2026 pp. 111134 10.1016/j.jbc.2026.111134

Identification and characterization of vasoactive intestinal peptide receptor antagonists with high-affinity and potent anti-leukemia activity

Yuou Wang, Anish Sen-Majumdar, Jian-Ming Li et al. Mar 01, 2026 pp. 111127 10.1016/j.jbc.2025.111127

JBC reviews tribute to the memory of Dr William (Bill) Smith (1945–2024)

George M. Carman Mar 01, 2026 pp. 111287 10.1016/j.jbc.2026.111287

O-GlcNAcase promotes dendritic spine morphogenesis while downregulating their GluA2-containing AMPA receptors

Linkun Han, Sabrina Galizia, Jingyu Pan et al. Mar 01, 2026 pp. 111157 10.1016/j.jbc.2026.111157

AHCY: A metabolic gatekeeper at the interface of methylation, redox balance, and cellular stress response

Sarah C. Stanhope, Vikki M. Weake Mar 01, 2026 pp. 111220 10.1016/j.jbc.2026.111220

From a single C-mannose to multiple C-mannosyltransferases

Hans Bakker, Christoph Garbers, Françoise H. Routier Mar 01, 2026 pp. 111266 10.1016/j.jbc.2026.111266

Mechanisms of protein degradation in atrophying muscles: What have we learned during the past decade?

Shenhav Shemer Mar 01, 2026 pp. 111229 10.1016/j.jbc.2026.111229

Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer’s disease

Grigoria Tsaka, Aida Montserrat Pagès, Cristiano Brás De Sousa et al. Mar 01, 2026 pp. 111221 10.1016/j.jbc.2026.111221

Modernizing biomolecular NMR: The POKY suite

Abigail Chiu, Woonghee Lee Mar 01, 2026 pp. 111246 10.1016/j.jbc.2026.111246

Alzheimer’s disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II

Miranda A. Salvo, Leah K. Cuddy, Dmitry Prokopenko et al. Mar 01, 2026 pp. 111171 10.1016/j.jbc.2026.111171

Cytomegalovirus-encoded immediate early 1 protein perturbs neural progenitor proliferation via interfering with host PML–DISC1 interaction

Atsushi Saito, Stephanie Tankou, Kazuhiro Ishii et al. Mar 01, 2026 pp. 111269 10.1016/j.jbc.2026.111269

The retaining kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes

Manitabhai Govind, Mikel Jason Allas, Bo-Shun Huang et al. Mar 01, 2026 pp. 111162 10.1016/j.jbc.2026.111162

Metformin suppresses PPARδ-driven CD47 transcription to enhance macrophage phagocytosis in lung cancer

Qian Cui, Huijie Wang, Hongxu Yu et al. Mar 01, 2026 pp. 111159 10.1016/j.jbc.2026.111159

Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Mikkel Madsen, Mette E. Rønne, Agnes B. Petersen et al. Mar 01, 2026 pp. 111227 10.1016/j.jbc.2026.111227

Large extracellular vesicles regulate endothelial angiogenic potential via paracrine and autocrine signaling

Grace Richmond, Rose Nguyen, Alanna Sedgwick et al. Mar 01, 2026 pp. 111193 10.1016/j.jbc.2026.111193

Writers and readers of sialylation in immunoregulation in cancer

Mathieu Decloquement, Matthew S. Macauley Mar 01, 2026 pp. 111249 10.1016/j.jbc.2026.111249

Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress

Ruiying Hu, Yu Wang, Mahircan Yagan et al. Mar 01, 2026 pp. 111164 10.1016/j.jbc.2026.111164

HSP-1-specific nanobodies alter chaperone function in vitro and in vivo

Nicholas D. Urban, Kunal Gharat, Zachary J. Mattiola et al. Mar 01, 2026 pp. 111238 10.1016/j.jbc.2026.111238

Unraveling the regioselectivity of Ophiostoma piceae sterol esterase as a case study for lipases with wide acyl-binding tunnel entrances

Juno Lee, Yoonseok Choi, Taehyeong Kim et al. Mar 01, 2026 pp. 111230 10.1016/j.jbc.2026.111230