Journal of Biological Chemistry

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation

Christina Michail, Jérémy Berthelet, Ariel E. Mechaly et al. Mar 01, 2026 pp. 111259 10.1016/j.jbc.2026.111259

Acid ceramidase ASAH1 is a key regulator of epidermal ceramide levels and composition

Wakana Nobumoto, Tatsuro Naganuma, Nana Nozaka et al. Mar 01, 2026 pp. 111178 10.1016/j.jbc.2026.111178

RNA-binding protein tristetraprolin inhibits Th2 cell activation and differentiation in allergic rhinitis by promoting TRIM18 mRNA decay

Dongsheng Xing, Hongwei Cao, Yan Yang et al. Mar 01, 2026 pp. 111240 10.1016/j.jbc.2026.111240

SIRT7 safeguards ERα proteostasis via deacetylation-dependent degradation of unliganded and misfolded receptors

Mengdi Cao, Junfeng Zhang, Huixia Liu et al. Mar 01, 2026 pp. 111173 10.1016/j.jbc.2026.111173

Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro

Ali Jasim Mohammad Jamil, Mikkel Ørnfeldt Nørgård, Emilie Grupe et al. Mar 01, 2026 pp. 111183 10.1016/j.jbc.2026.111183

Antagonist nanobodies prevent protease inhibition by CD109

Kathrine Tejlgård Jensen, Ana Viana Almeida, Sanne Rönning et al. Mar 01, 2026 pp. 111187 10.1016/j.jbc.2026.111187

Unusual and atypical cyclooxygenase reactions

Claus Schneider, Alan R. Brash Mar 01, 2026 pp. 111247 10.1016/j.jbc.2026.111247

Delineation of the active site of MtgB, a cobalamin-dependent glycine betaine methyltransferase

Jonathan Picking, Yunfeng Li, Tomislav Ticak et al. Mar 01, 2026 pp. 111216 10.1016/j.jbc.2026.111216

Mannose metabolic pathway senses glucose supply and regulates cell fate decisions

Ziwei Wang, Yasuhide Miyamoto, Takehiro Suzuki et al. Mar 01, 2026 pp. 111213 10.1016/j.jbc.2026.111213

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

Konstantia Georgouli, Jeremy O.B. Tempkin, Liam G. Stanton et al. Mar 01, 2026 pp. 111237 10.1016/j.jbc.2026.111237

A missense mutation in acyl-CoA synthetase ACSL4 reveals essential residues for catalytic activity in ferroptosis

Haruka Sei, Harumi Ando, Fumie Nakashima et al. Mar 01, 2026 pp. 111232 10.1016/j.jbc.2026.111232

Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1

Tim Nass, Anna D. Reichardt, Saba R. Aliyari et al. Mar 01, 2026 pp. 111204 10.1016/j.jbc.2026.111204

A submission checklist to improve transparency and replicability of functional genomics data analyses

Austin J. Hepperla, Ross C. Hardison, Roger J. Colbran et al. Mar 01, 2026 pp. 111285 10.1016/j.jbc.2026.111285

Disruptions of cell signaling pathways in myotonic dystrophy type 1 skeletal muscle, their pathogenic impact, and potential for combinatorial therapeutics

Aymeric Ravel-Chapuis, Shatha A. Atieh, Chimène Fahmi et al. Mar 01, 2026 pp. 111219 10.1016/j.jbc.2026.111219

Engineered IgA-Fc fusion protein with bioactive nanobody neutralizes SARS-CoV-2 variants with mucosal delivery potential

Rachel M. Golonka, Lauren E. Intravaia, Ala M. Shaqra et al. Mar 01, 2026 pp. 111210 10.1016/j.jbc.2026.111210

A cell-based assay for retinaldehyde dehydrogenase activity: Retinoid quantification as an alternative to current fluorescence-based approaches

Julie Charpentier, Yan Lu, Serena Gallozzi et al. Mar 01, 2026 pp. 111211 10.1016/j.jbc.2026.111211

BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication

Roy Hanna, Eric Deneault, Gilbert Bernier Mar 01, 2026 pp. 111172 10.1016/j.jbc.2026.111172

Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammation

Mohd Yasir Khan, Kashika Singh, Alia Hashmi et al. Mar 01, 2026 pp. 111186 10.1016/j.jbc.2026.111186

Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis

Tinkara Kreft, Kaja Blagotinšek Cokan, Cene Skubic et al. Mar 01, 2026 pp. 111188 10.1016/j.jbc.2026.111188

Bacteriocin biophysics: From protein–protein interaction models to navigators of the bacterial cell envelope

Colin Kleanthous Mar 01, 2026 pp. 111185 10.1016/j.jbc.2026.111185

The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate–binding domain

Akshitha Maqtedar, Maria-Agustina Rossi, Eugenia M. Clerico et al. Mar 01, 2026 pp. 111176 10.1016/j.jbc.2026.111176

Hydrophobic interactions determine the optimum temperature of a housekeeping enzyme

Tatsuya Yamamoto, Akira Shiraishi, Tsubasa Sakai et al. Mar 01, 2026 pp. 111234 10.1016/j.jbc.2026.111234

TORC2 coordinates MBF-dependent transcription and restrains oxidative stress responses during DNA replication stress in fission yeast

Adiel Cohen, Ava Mouzon, Uri Sprecher et al. Mar 01, 2026 pp. 111242 10.1016/j.jbc.2026.111242

Time-resolved Mn Kα emission reveals early redox dynamics in the S3 to S0 transition of the photosystem II Kok cycle

Olga Maximova, Sudip Bhowmick, Hasan Tuncer et al. Mar 01, 2026 pp. 111215 10.1016/j.jbc.2026.111215

Photodynamic activation of a KRAS RNA G-quadruplex–targeted photosensitizer induces ferroptosis in cisplatin-resistant non–small cell lung cancer

Xiao-Dong Wang, Jia-Hong Lin, Ming-Hao Hu Mar 01, 2026 pp. 111181 10.1016/j.jbc.2026.111181