Journal of Biological Chemistry

A comprehensive discovery platform for ELOVL1 small-molecule inhibitors targeting very long-chain fatty acid synthesis in adrenoleukodystrophy

Stephanie Holley, Gary Asmussen, Becky Lam et al. Jun 01, 2026 pp. 113103 10.1016/j.jbc.2026.113103

Disruption of GxxxG motifs in pATOM36 impairs biogenesis of the mitochondrial protein translocase of the outer membrane in Trypanosoma brucei

Stephan Berger, Siri Speck, André Schneider et al. Jun 01, 2026 pp. 113126 10.1016/j.jbc.2026.113126

Kif15 orchestrates neuronal–microglial communication via CX3CL1 to impede nerve regeneration

Ronghua Wu, Wei Zhang, Xiaowei Qian et al. Jun 01, 2026 pp. 113090 10.1016/j.jbc.2026.113090

An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability

Ke Xu, Stéphanie Bianco, Charles Joly Beauparlant et al. Jun 01, 2026 pp. 113107 10.1016/j.jbc.2026.113107

Insights into the role of internal catalysts in asparagine-to-succinimide conversion in a hyperthermophilic glutamine amidotransferase

Anusha Chandrashekarmath, Oishika Jash, Karandeep Singh et al. Jun 01, 2026 pp. 113093 10.1016/j.jbc.2026.113093

Impact of heme on the therapeutic efficacy of anti-CD20 antibodies

Annaelle Marey-Jarossay, Alexia Tavares, Robin V. Lacombe et al. Jun 01, 2026 pp. 111485 10.1016/j.jbc.2026.111485

Lipid transfer proteins and PI4KIIα generate a phosphoinositide-linked proteome

Noah D. Carrillo, Mo Chen, Poorwa Awasthi et al. Jun 01, 2026 pp. 113089 10.1016/j.jbc.2026.113089

Structural determinants of ligand response specificity in the mast cell activating GPCR, MRGPRX2

Abiodun Adefola R. Adeosun, Melina A. Agosto, Olivier Lichtarge et al. Jun 01, 2026 pp. 113132 10.1016/j.jbc.2026.113132

The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae

Sheetal Paliwal, Partha Dey, Akriti Kumari et al. Jun 01, 2026 pp. 113064 10.1016/j.jbc.2026.113064

Herpes simplex virus alkaline nuclease interacts directly with ubiquitin-specific protease 15 through a conserved C-terminal domain

Alexander Leehangin, Tyler D. Hasselmann, Jessica Pagelkopf et al. Jun 01, 2026 pp. 111444 10.1016/j.jbc.2026.111444

The HypA and HypB metallochaperones from Methanococcus maripaludis have unique metal-binding properties and a distinct nickel transfer mechanism

Thuc-Anh Dinh, Nanqi Jiang, Kimberly B. Lyons et al. Jun 01, 2026 pp. 111477 10.1016/j.jbc.2026.111477

Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes

Amna Abbas, David Sychantha, Kalinka Koteva et al. Jun 01, 2026 pp. 111479 10.1016/j.jbc.2026.111479

Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry

Nicole S. MacRae, Ken C. Dong, Hiromitsu Harimoto et al. Jun 01, 2026 pp. 111481 10.1016/j.jbc.2026.111481

A cryptic-site ligand stabilizes a non-canonical interface and blocks membrane insertion of the chloride intracellular channel CLIC1

Shobhan Kuila, Archita Ghoshal, Sibasis Sahoo et al. Jun 01, 2026 pp. 113113 10.1016/j.jbc.2026.113113

Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology

Courtney M. Mazur, Parthena E. Kotsalidis, Majd George et al. Jun 01, 2026 pp. 113075 10.1016/j.jbc.2026.113075

Pharmacological targeting of the mycothiol cysteine ligase MshC in Mycobacterium abscessus

Thanh Quang Nguyen, Claire Hamela, Luping Pang et al. Jun 01, 2026 pp. 111433 10.1016/j.jbc.2026.111433

Dynamic mechanism for subtype selectivity of endocannabinoids

Soumajit Dutta, Lawrence Zhao, Diwakar Shukla Jun 01, 2026 pp. 111434 10.1016/j.jbc.2026.111434

Iron-sulfur cofactors in nucleic acid metabolism and protein synthesis: Assembly, delivery, and putative roles in cellular and viral systems

Nunziata Maio, Tracey A. Rouault Jun 01, 2026 pp. 113129 10.1016/j.jbc.2026.113129

The E3 ligase β-TRCP1 earmarks OTUD3 for destruction to fine-tune cGAS activation

Jianfeng Chen, Smaran Sivashankar, Ying Wang et al. Jun 01, 2026 pp. 111461 10.1016/j.jbc.2026.111461

HIRA-SETDB1-H3K9me3 axis regulates chromatin architecture in leukemia cells

Mayur Balkrishna Shirude, Anjali Devarajan, Sai Adarsh Sahu et al. Jun 01, 2026 pp. 113081 10.1016/j.jbc.2026.113081

Deletion of mitochondrial calcium uniporter enhances calcium signals by slowing calcium clearance and triggers adaptive transcriptomic remodeling

Rajesh Bhardwaj, Abdull J. Massri, Gary S. Bird et al. Jun 01, 2026 pp. 111473 10.1016/j.jbc.2026.111473

Histone H2B-associated proteins: The Arabidopsis nucleolin 1 binds H2B and facilitates nucleosome disassembly via RNA-dependent mechanism

Naveen Kumar Yarra, Jeevan R. Singiri, Zachor Agmon-Adler et al. Jun 01, 2026 pp. 113137 10.1016/j.jbc.2026.113137

Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling

Mineko Tomomura, Takao Tsukahara, Ryuichiro Suzuki et al. Jun 01, 2026 pp. 113108 10.1016/j.jbc.2026.113108

Role of mitochondrial translation in modulating inflammatory disease outcome: Current knowledge and future perspectives

Swarnali Basu, Rukshar Khan, Shiva Sharma et al. Jun 01, 2026 pp. 111455 10.1016/j.jbc.2026.111455

Potassium suppresses allosteric activation of ZAP-70-dependent T cell receptor signaling

Swarnendu Roy, Soumee SenGupta, Kaustav Gangopadhyay et al. Jun 01, 2026 pp. 113083 10.1016/j.jbc.2026.113083