Journal of Biological Chemistry

Proximal cysteine residues in proteins promote Nε-carboxyalkylation of lysine residues by α-dicarbonyl compounds

Sudipta Panja, Johanna Rankenberg, Cole Michel et al. Apr 01, 2025 pp. 108377 10.1016/j.jbc.2025.108377

A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate

Sandra Koit, Nele Tamberg, Allan Reinapae et al. Apr 01, 2025 pp. 108408 10.1016/j.jbc.2025.108408

Targeting HNRNPA2B1 to overcome chemotherapy resistance in gastric cancer stem cells: Mechanisms and therapeutic potential

Miao Yu, Bingyuan Fei, Songtao Chu Apr 01, 2025 pp. 108234 10.1016/j.jbc.2025.108234

Declining activity of serum response factor in aging aorta in relation to aneurysm progression

Catarina Rippe, Joakim Armstrong Bastrup, Johan Holmberg et al. Apr 01, 2025 pp. 108400 10.1016/j.jbc.2025.108400

Antimicrobial peptides selectively target malaria parasites by a cholesterol-dependent mechanism

Edo Kiper, Daniel Ben Hur, Daniel Alfandari et al. Apr 01, 2025 pp. 108298 10.1016/j.jbc.2025.108298

The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins

Di Liu, Xin-Yu Huo, Xiaoli Zhang et al. Apr 01, 2025 pp. 108403 10.1016/j.jbc.2025.108403

Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival

Emma C. Rowland, Matthew D'Antuono, Anna M. Jermakowicz et al. Apr 01, 2025 pp. 108349 10.1016/j.jbc.2025.108349

A combination of alveolar type 2–specific p38α activation with a high-fat diet increases inflammatory markers in mouse lungs

C.K. Matthew Heng, Ilona Darlyuk-Saadon, Wupeng Liao et al. Apr 01, 2025 pp. 108425 10.1016/j.jbc.2025.108425

Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet

Jonathan Snyder, Chun-sun Jiang, Ran Hee Choi et al. Apr 01, 2025 pp. 108388 10.1016/j.jbc.2025.108388

Characterization of a rhodopsin-phosphodiesterase from Choanoeca flexa to be combined with rhodopsin-cyclases for bidirectional optogenetic cGMP control

Nicolas Liem, Anika Spreen, Arita Silapētere et al. Apr 01, 2025 pp. 108401 10.1016/j.jbc.2025.108401

Dioxygenation of tryptophan residues by superoxide and myeloperoxidase

Nina Dickerhof, Louisa V. Ashby, Daniel Ford et al. Apr 01, 2025 pp. 108402 10.1016/j.jbc.2025.108402

Immune checkpoint protein PD-L1 promotes transcription of angiogenic and oncogenic proteins IL-8, Bcl3, and STAT1 in ovarian cancer cells

Suprataptha U. Reddy, Rachel Sham, Khalani Smith et al. Apr 01, 2025 pp. 108339 10.1016/j.jbc.2025.108339

New routes for spermine biosynthesis

Bin Li, Hamid R. Baniasadi, Jue Liang et al. Apr 01, 2025 pp. 108390 10.1016/j.jbc.2025.108390

ER stress and viral defense: Advances and future perspectives on plant unfolded protein response in pathogenesis

Binita Adhikari, Jeanmarie Verchot, Federica Brandizzi et al. Apr 01, 2025 pp. 108354 10.1016/j.jbc.2025.108354

Enhanced identification of small molecules binding to hnRNPA1 via cryptic pockets mapping coupled with X-ray fragment screening

Louise Dunnett, Sayan Das, Vincenzo Venditti et al. Apr 01, 2025 pp. 108335 10.1016/j.jbc.2025.108335

Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis

Aron A. Shoara, Sladjana Slavkovic, Miguel A.D. Neves et al. Apr 01, 2025 pp. 108392 10.1016/j.jbc.2025.108392

The ROGDI protein mutated in Kohlschutter–Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly

Samuel R. Winkley, Patricia M. Kane Apr 01, 2025 pp. 108381 10.1016/j.jbc.2025.108381

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells

Maria J. Pires, Seher Alam, Alen Lovric et al. Apr 01, 2025 pp. 108361 10.1016/j.jbc.2025.108361

A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation

Ryota Sugawara, Keisuke Hamada, Hidenori Ito et al. Apr 01, 2025 pp. 108346 10.1016/j.jbc.2025.108346

Antioxidant-independent activities of alpha-tocopherol

Matthew Chen, Mikel Ghelfi, Jia-Fei Poon et al. Apr 01, 2025 pp. 108327 10.1016/j.jbc.2025.108327

Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters

Qingjie Xiao, Xinyi Chen, Chen Wang et al. Apr 01, 2025 pp. 108357 10.1016/j.jbc.2025.108357

Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation

Lorena Camargo-Ayala, Mauricio Bedoya, Albert Dasí et al. Apr 01, 2025 pp. 108387 10.1016/j.jbc.2025.108387

Dynamic interactions of dimeric hub proteins underlie their diverse functions and structures: A comparative analysis of 14-3-3 and LC8

Jesse Howe, Elisar J. Barbar Apr 01, 2025 pp. 108416 10.1016/j.jbc.2025.108416

Human glutathione transferases catalyze the reaction between glutathione and nitrooleic acid

Martina Steglich, Nicole Larrieux, Ari Zeida et al. Apr 01, 2025 pp. 108362 10.1016/j.jbc.2025.108362

PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

Dillon M. Voss, Alexander J. Kral, GeunYoung Sim et al. Apr 01, 2025 pp. 108345 10.1016/j.jbc.2025.108345