Journal of Biological Chemistry

Inhibitory effects of β-galactoside α2,6-sialyltransferase 1 on the Hippo pathway in breast cancer cells

Qinglei Hang, Wenqian Li, Jingya Guo et al. Oct 01, 2025 pp. 110266 10.1016/j.jbc.2025.110266

The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations

Birte Hagemeier, Kamilla Ripkens, Nina Schulze et al. Oct 01, 2025 pp. 110729 10.1016/j.jbc.2025.110729

Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control

Yun-Ji Shin, Ulrike Vavra, Daniel Maresch et al. Oct 01, 2025 pp. 110649 10.1016/j.jbc.2025.110649

Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides

Xun Sun, Rose Pedretti, H. Jane Dyson et al. Oct 01, 2025 pp. 110594 10.1016/j.jbc.2025.110594

Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate

Subrata Munan, Belem Yoval-Sánchez, Canglin Yao et al. Oct 01, 2025 pp. 110685 10.1016/j.jbc.2025.110685

Branched DNA processing by a thermostable CAS-Cas4 from Thermococcus onnurineus: Expanding biochemical landscape of nuclease activity

Muskan Jain, Asish Kumar Pattnayak, Sakshi Aggarwal et al. Oct 01, 2025 pp. 110701 10.1016/j.jbc.2025.110701

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway

Sang Ah Yi, Liang Sun, Yi Rao et al. Oct 01, 2025 pp. 110660 10.1016/j.jbc.2025.110660

The bacterial tRNA-modifying enzyme tRNAIle lysidine synthetase is genetically conserved but catalytically variable

Marc J. Muraski, Ferdiemar C. Guinto, Emil M. Nilsson et al. Oct 01, 2025 pp. 110688 10.1016/j.jbc.2025.110688

A Pseudomonas aeruginosa endolytic muramidase targets cell-wall peptidoglycan in bacterial competition

Tietao Wang, Lin Zhang, Mijoon Lee et al. Oct 01, 2025 pp. 110642 10.1016/j.jbc.2025.110642

Receptor activity–modifying protein 3 enhances GLP-1-mediated insulin secretion

Abigail Pearce, Poonam Kumari, Claudia M. Sisk et al. Oct 01, 2025 pp. 110604 10.1016/j.jbc.2025.110604

Identification of ALKBH6 as a nucleotide demethylase with a distinct substrate preference

Susmita Das, Sourbh Rankawat, Unnikrishnan P. Shaji et al. Oct 01, 2025 pp. 110638 10.1016/j.jbc.2025.110638

10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry, activation, and signalling

Sebastian Grant, Dave Boucher Oct 01, 2025 pp. 110557 10.1016/j.jbc.2025.110557

A comparative analysis reveals electrogenic properties of PfCRT and pendrin

Eva Gil-Iturbe, Matthias Quick Oct 01, 2025 pp. 110630 10.1016/j.jbc.2025.110630

In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion

Yan Zhou, Nicolas Baez, Tingting Fu et al. Oct 01, 2025 pp. 110661 10.1016/j.jbc.2025.110661

Suppression of SREBP by a transmembrane protein mutated in cardiomyopathy

Yasushi Takemoto, Manchir Tserendagva, Motonari Uesugi Oct 01, 2025 pp. 110644 10.1016/j.jbc.2025.110644

The activity of the EMT suppressor GRHL2 is regulated by SUMOylation

Sonja Santjer, Yang Xu, Sabine Riethdorf et al. Oct 01, 2025 pp. 110662 10.1016/j.jbc.2025.110662

Functional dissection of the zDHHC palmitoyltransferase 5–golgin A7 palmitoylation complex

Martha A. Kahlson, Joan Ritho, João Victor Gomes et al. Oct 01, 2025 pp. 110694 10.1016/j.jbc.2025.110694

Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase

Joseph V. Roman, Yashvi Shukla, David A. Hanna et al. Oct 01, 2025 pp. 110681 10.1016/j.jbc.2025.110681

Protein inhibitor of retinal membrane guanylyl cyclase suppresses cGMP synthesis in photoreceptors

Igor V. Peshenko, Elena V. Olshevskaya, Alexander M. Dizhoor Oct 01, 2025 pp. 110718 10.1016/j.jbc.2025.110718

Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14

Percy S. Agogo-Mawuli, Isra Sadiya, Tigran M. Abramyan et al. Oct 01, 2025 pp. 110611 10.1016/j.jbc.2025.110611

FAT-5/SCD5-mediated lipid localization in lysosomes alleviates gamma radiation injury in Caenorhabditis elegans

Tong Zhu, Zhouxuan Wang, Jiaze Li et al. Oct 01, 2025 pp. 110674 10.1016/j.jbc.2025.110674

The hypoxia-induced chromatin reader ZMYND8 drives HIF-dependent metabolic rewiring in breast cancer

Sandhik Nandi, Atanu Mondal, Ishita Sarkar et al. Oct 01, 2025 pp. 110680 10.1016/j.jbc.2025.110680

Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus

Stefan Bauernfried, Tobias Komar, Katja Sterle et al. Oct 01, 2025 pp. 110574 10.1016/j.jbc.2025.110574

Correction: Mechanism of glutathionylation of the active site thiols of peroxiredoxin 2

Alexander V. Peskin, Flavia C. Meotti, Nicholas J. Magon et al. Oct 01, 2025 pp. 110628 10.1016/j.jbc.2025.110628

Pharmacologic stimulation of insulin granule acidification increases β-cell zinc content and augments β-cell-targeted drug delivery

Sooyeon Lee, Hannah P. Fraser, Rebecca C. Schugar et al. Oct 01, 2025 pp. 110645 10.1016/j.jbc.2025.110645