Journal of Biological Chemistry

Ubiquitin-specific protease 7 promotes the growth and oncogenic potential of acute myeloid leukemia cells through the deubiquitination and upregulation of LRRK2

Joon Hyung Park, Kwang Chul Chung Oct 01, 2025 pp. 110675 10.1016/j.jbc.2025.110675

TOR signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating pathway

Nicholas R. Leclerc, Toby M. Dunne, Sudati Shrestha et al. Oct 01, 2025 pp. 110700 10.1016/j.jbc.2025.110700

A unique gating mechanism revealed by the cryo-EM structure of monomeric ATP9A flippase

Kazuhiro Abe, Parthiban Marimuthu, Yuheng Qian et al. Oct 01, 2025 pp. 110631 10.1016/j.jbc.2025.110631

Kinetic mechanisms of electron bifurcation with electron transfer flavoprotein, NADH, butyryl-CoA dehydrogenase, and ferredoxin reveal a semiquinone cycle

Jeerus Sucharitakul, Montisa Mangkalee, Pattarawan Intasian et al. Oct 01, 2025 pp. 110727 10.1016/j.jbc.2025.110727

Ciprofloxacin enhances RSL3-induced ferroptosis by promoting mitochondrial Zn2+ accumulation via the STING1–CAV2 pathway

Hu Tang, Fangquan Chen, Xiutao Cai et al. Oct 01, 2025 pp. 110653 10.1016/j.jbc.2025.110653

The trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA

Anna Zavrelova, Siqi Shen, Farnaz Zahedifard et al. Oct 01, 2025 pp. 110706 10.1016/j.jbc.2025.110706

Class I histone deacetylases catalyze lysine lactylation

Michelangelo B. Gonzatti, Jordi C.J. Hintzen, Isha Sharma et al. Oct 01, 2025 pp. 110602 10.1016/j.jbc.2025.110602

African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination

Jinyu Zhao, Xinyu Zhang, Chunxiao Mou et al. Oct 01, 2025 pp. 110669 10.1016/j.jbc.2025.110669

Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism

Julius Chembo, Brittany M. Bowman, Kyle Lapak et al. Oct 01, 2025 pp. 110659 10.1016/j.jbc.2025.110659

Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression

Li Zhao, Xixi Qian, Yaoyao Fan et al. Oct 01, 2025 pp. 110687 10.1016/j.jbc.2025.110687

SA-XV, a 15-amino acid fragment of host defense peptide S100A12, targets mitochondria and is protective against fungal infections

Riddhi Agarwal, Karishma Biswas, Akshita Agrawal et al. Oct 01, 2025 pp. 110743 10.1016/j.jbc.2025.110743

Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1

Heidi L. Fresenius, Brian Acquaviva, Deepika Gaur et al. Oct 01, 2025 pp. 110614 10.1016/j.jbc.2025.110614

Dominant-negative NARS1 R534∗ mutation causes wild-type subunit poisoning and heterodimer predominance in cells

Ingrid Vallee, Ryan Shapiro, Leo Qi et al. Oct 01, 2025 pp. 110690 10.1016/j.jbc.2025.110690

The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25

Yubo Guo, Shuang Zhu, Wenjie Wu et al. Oct 01, 2025 pp. 110689 10.1016/j.jbc.2025.110689

Loss of angulin-1/LSR promotes vasculogenic mimicry and epithelial-mesenchymal transition in breast cancer

Yuma Yoshioka, Chisato Nosaka, Tomokazu Ohishi et al. Oct 01, 2025 pp. 110635 10.1016/j.jbc.2025.110635

β-hydroxybutyrate dehydrogenase promotes pancreatic cancer cell proliferation through regulation of the NAD+/NADH balance and mitochondrial acetylation

Xiujuan Wei, Chengkai Zhang, Xiaoguang Zheng et al. Oct 01, 2025 pp. 110636 10.1016/j.jbc.2025.110636

Phosphatidylinositol 3-phosphate metabolism impacts cellular α-synuclein localization in Saccharomyces cerevisiae

Timo Löser, Fazilet Bekbulat, Christian Behl et al. Oct 01, 2025 pp. 110666 10.1016/j.jbc.2025.110666

Important amino acid residues in the chloride pump halorhodopsin that accelerate ion transport despite no direct interaction with the substrate

Yubo Zhai, Anna Shimosaka, Takashi Tsukamoto et al. Oct 01, 2025 pp. 110703 10.1016/j.jbc.2025.110703

A yeast-based in vivo assay complements in vitro and in silico approaches to characterize sterol-binding by Saccharomyces cerevisiae Lam/Ltc proteins

Ola El Atab, Barkha Gupta, Zhu Han et al. Oct 01, 2025 pp. 110663 10.1016/j.jbc.2025.110663

Protein activities driven by amino acid composition

Sean M. Cascarina, Eric D. Ross Oct 01, 2025 pp. 110640 10.1016/j.jbc.2025.110640

MarK, a Novosphingobium aromaticivorans kinase required for catabolism of multiple aromatic monomers

Benjamin W. Hall, Jeanette C. Neri, Craig A. Bingman et al. Oct 01, 2025 pp. 110606 10.1016/j.jbc.2025.110606

The complete λ-carrageenan depolymerization cascade from a marine Pseudoalteromonad revealed by structural analysis of the enzymes

Chelsea J. Vickers, Andrew G. Hettle, Joanne K. Hobbs et al. Oct 01, 2025 pp. 110719 10.1016/j.jbc.2025.110719

GreenCells: A comprehensive resource for single-cell analysis of plant lncRNAs

Changxiong Wu, Jiazhi Liu, Yan Li et al. Oct 01, 2025 pp. 110678 10.1016/j.jbc.2025.110678

A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap

Danielle M. Blazier, Eric M. Lewandowski, Natasha Ram et al. Oct 01, 2025 pp. 110665 10.1016/j.jbc.2025.110665

Lipid metabolism on and off the beaten path

Rosalind A. Coleman Oct 01, 2025 pp. 110697 10.1016/j.jbc.2025.110697