Journal of Biological Chemistry

The cannabinoid receptor 1 suppresses neuropeptide Y transcription in the peripheral nervous system to mediate analgesia

YongMin Liu, Xue Gong, Yindi Wang et al. Jul 01, 2026 pp. 113350 10.1016/j.jbc.2026.113350

The deubiquitinase CYLD inhibits thrombin-induced p38 MAPK–p65 NF-κB signaling and inflammatory cytokine production to suppress triple-negative breast cancer progression

Julio M. Pimentel, Oye Bosompra, JoAnn Trejo Jul 01, 2026 pp. 113341 10.1016/j.jbc.2026.113341

Synergistic modulation of cAMP and cGMP rescues hemin-induced plasma membrane fragmentation

Zoi Laspa, Anne-Katrin Rohlfing, Melina Fischer et al. Jul 01, 2026 pp. 113357 10.1016/j.jbc.2026.113357

O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex

Talia Hart, Ashley Duke, Yifei Zhou et al. Jul 01, 2026 pp. 113343 10.1016/j.jbc.2026.113343

The structure of the SufBC2D-SufE complex reveals the mechanism of sulfur transfer in bacterial Fe-S cluster assembly

Nidhi Chhikara, Nadia Mireku, Jack A. Dunkle et al. Jul 01, 2026 pp. 113328 10.1016/j.jbc.2026.113328

Evolution- and structure-guided redesign of the Stachel motif yields soluble and potent modulators of adhesion GPCRs

Abibe Useini, Yue Feng, Isabell Kaczmarek et al. Jul 01, 2026 pp. 113323 10.1016/j.jbc.2026.113323

Rational engineering of the Arabidopsis thaliana plant cysteine oxidase 4 active site can reduce biochemical activity and improve submergence tolerance

Anna Dirr, Arianna Del Greco, Simon Howe et al. Jul 01, 2026 pp. 113331 10.1016/j.jbc.2026.113331

Dynamic O-GlcNAcylation of Sec23-interacting protein regulates COPII function

Tetsuya Hirata, Quyen Nguyen, Coco Liu et al. Jul 01, 2026 pp. 113356 10.1016/j.jbc.2026.113356

Distinct Nuclear Localization Signals Confer Differential Microtubule Dependence among ZFTA Fusion Oncoproteins

Masaki Ishii, Naoki Suto, Ruri Kojima et al. Jul 01, 2026 pp. 113320 10.1016/j.jbc.2026.113320

Conditional dependency of oncogenic KRAS in driving ketone body catabolism and pancreatic cancer growth

Runze Wang, Xue Li, Tongxin Zhang et al. Jul 01, 2026 pp. 113332 10.1016/j.jbc.2026.113332

TIP60 promotes chemoresistance by limiting intracellular platinum accumulation and enhancing removal of cisplatin-DNA adducts

Akshay Hira, Michael P. Craig, Caroline McLaughlin et al. Jul 01, 2026 pp. 113338 10.1016/j.jbc.2026.113338

The DNTTIP1-PARP1 Interaction Orchestrates MiDAC Recruitment and Activity for NHEJ-Mediated Genome Stability

Yan Qin, Yanhui Ma, Ao Wei et al. Jul 01, 2026 pp. 113342 10.1016/j.jbc.2026.113342

Oncogenic EGFR Mutants Differentially Alter Dimerization, Adaptor Protein Engagement, and Clathrin-Mediated Internalization

Maryam Bello-Hassan, Pradeep Kumar Singh, Adam W. Smith Jul 01, 2026 pp. 113353 10.1016/j.jbc.2026.113353

IGSF3 drives acquired temozolomide resistance in glioblastoma through ASNS-dependent asparagine biosynthesis

Jie Li, Hongnian Lu, Qianqian Xu et al. Jul 01, 2026 pp. 113359 10.1016/j.jbc.2026.113359

Histone Acetyltransferase HAT1 Regulates Intestinal Stem Cell Proliferation and Differentiation

Prabakaran Nagarajan, Caden J. Martin, Andrea R. Keller et al. Jul 01, 2026 pp. 113368 10.1016/j.jbc.2026.113368

Macrocyclic and linear peptides promote LAR dimerization and neurite outgrowth

Misato Yasumura, YuChen Zhang, Tokuichi Iguchi et al. Jul 01, 2026 pp. 113340 10.1016/j.jbc.2026.113340

The GCP16-zDHHC9 S-acyltransferase complex: reciprocal effects on protein S-acylation and stability

Despoina Allagioti, Andrew J. Thompson, Mohammad A. Al-Mhadeen et al. Jul 01, 2026 pp. 113349 10.1016/j.jbc.2026.113349

Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice

Melissa M. Rowe, Joanna Tober, Vivian Ortiz et al. Jul 01, 2026 pp. 113364 10.1016/j.jbc.2026.113364

The N-terminal domain of the endoplasmic reticulum-resident chaperone Grp94 functions in aggregation prevention

Ayodeji Adedeji, Erin Unruh, Alyssa Derr et al. Jul 01, 2026 pp. 113358 10.1016/j.jbc.2026.113358

Lauric acid engages an O-GlcNAc–sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes.

Koichiro Sumi, Miho Shioyama, Kinuyo Munakata et al. Jul 01, 2026 pp. 113345 10.1016/j.jbc.2026.113345

HSP90 Inhibition Partially Rescues Alternative Splicing Dysregulation in Cell Models of Myotonic Dystrophy

Jing Zhang, Amy Mascorro, Humayra Oishi et al. Jul 01, 2026 pp. 113354 10.1016/j.jbc.2026.113354

A biosensor platform for scalable and live detection of PYY hormone production from enteroendocrine cells with single-event resolution

Aanya Hirdaramani, Gary Frost, Aylin C. Hanyaloglu Jul 01, 2026 pp. 113367 10.1016/j.jbc.2026.113367

Engineering internally His-tagged ESX secretion system fusion antigens for tuberculosis nanoparticle vaccines

Wen-Ling Hsu, Yang Jiao, Wei-Chiao Huang et al. Jul 01, 2026 pp. 113337 10.1016/j.jbc.2026.113337

Wanted and unwanted modifications of mRNA, and their effect on gene expression and signaling

Ankanahalli N. Nanjaraj Urs, Animesh Dali, Hani S. Zaher Jul 01, 2026 pp. 113314 10.1016/j.jbc.2026.113314

Insights into how JIP3 and JIP4 adaptor proteins relieve the auto-inhibited form of the kinesin-1 motor

Fernando Vilela, Mélanie Chenon, Valérie Campanacci et al. Jul 01, 2026 pp. 113355 10.1016/j.jbc.2026.113355