Journal of Biological Chemistry

Clinically observed RASA1 missense mutants exhibit diverse RasGAP protein behaviors in vitro

Maxum E. Paul, Rediet B. Delelegne, Jocelyn E. Chau et al. Jul 01, 2026 pp. 113201 10.1016/j.jbc.2026.113201

Oleoylethanolamide enhances regulatory T Cell function to accelerate plaque regression in atherosclerosis via PPARα activation

Tong Ren, Yanchao Jiao, Le Zhang et al. Jul 01, 2026 pp. 113236 10.1016/j.jbc.2026.113236

Dysregulated HELLS expression alters cellular processes and serves as a potential prognostic marker in acute myeloid leukemia

Swati Madhulika, T Sayamsmruti Panda, Priyanka Samal et al. Jul 01, 2026 pp. 113210 10.1016/j.jbc.2026.113210

Microglia maintain retinal redox homeostasis following ablation of rod photoreceptors in zebrafish

Michael Morales, Diana M. Mitchell Jul 01, 2026 pp. 113169 10.1016/j.jbc.2026.113169

The Ion channel, CFTR, assembles with HIPPO pathway proteins TAZ and YAP in polycystic kidney disease

Abhishek Sharma, Masoud Afshani, Cristian Ciobanu et al. Jul 01, 2026 pp. 113152 10.1016/j.jbc.2026.113152

Molecular mechanism of 2′,3′-cGAMP degradation by monkeypox virus poxin-schlafen protein

Yunxiao Huang, Benzhen Duan, Yang Xiao et al. Jul 01, 2026 pp. 113163 10.1016/j.jbc.2026.113163

The iron-sulfur cluster assembly factor FDX2 is required for tumor initiation but not for growth of established tumors in transplantation models

Eifumi Hashimoto, Mai Ohuchi, Miyuki Nomura et al. Jul 01, 2026 pp. 113200 10.1016/j.jbc.2026.113200

Stress-induced glucocorticoid signaling impairs enteric neurotrophin BDNF–TrkB pathway and drives gastrointestinal dysmotility

Jared Slosberg, Srinivas N. Puttapaka, Philippa Seika et al. Jul 01, 2026 pp. 113095 10.1016/j.jbc.2026.113095

Correction: Protein kinase a regulates cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP

Sendi Rafael Adame-Garcia, Thomas S. Hoang, Pham Thuy Tien Vo et al. Jul 01, 2026 pp. 113220 10.1016/j.jbc.2026.113220

A dual-pathway Wnt-IL-13 fusion protein enhances human intestinal regeneration through tuft cell activation

Li Yang, Lulu Huang, Fenna L.H. van Rijt et al. Jul 01, 2026 pp. 113187 10.1016/j.jbc.2026.113187

Correction: F2,6BP restores mitochondrial genome integrity in Huntington’s disease

Anirban Chakraborty, Santi M. Mandal, Mikita Mankevich et al. Jul 01, 2026 pp. 113173 10.1016/j.jbc.2026.113173

Reciprocal compensation of caspase-2 and p53 regulates the DNA damage response in HCT116 colon cancer cells

Karla E. Lopez, Leslie Bandera, Luiza E. Coutinho et al. Jul 01, 2026 pp. 113199 10.1016/j.jbc.2026.113199

Conserved residues in the Gα interface show subtype specificity in Gβγ coupling

Wenyuan Wei, H. Dalton Taylor, Ning Ma et al. Jul 01, 2026 pp. 113231 10.1016/j.jbc.2026.113231

Low-dose EGFR inhibition unlocks ferroptosis susceptibility to sensitize chemotherapy in EGFR-high triple-negative breast cancer

Xiaoxi Li, Ling Liu, Lingli Luo et al. Jul 01, 2026 pp. 113185 10.1016/j.jbc.2026.113185

Pontocerebellar hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization

Lizette Zavala, Magdalena Sobien, Cassandra K. Hayne Jul 01, 2026 pp. 113186 10.1016/j.jbc.2026.113186

GALNT7-induced O-glycosylation of NUP50 activates fatty acid β-oxidation to promote lung adenocarcinoma metastasis

Meiling Sheng, Beiwei Yu, Qunzhi Wang et al. Jul 01, 2026 pp. 113179 10.1016/j.jbc.2026.113179

KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53

Ezequiel J. Tolosa, Glancis L. Raja Arul, Ashley N. Sigafoos et al. Jul 01, 2026 pp. 113203 10.1016/j.jbc.2026.113203

Correction: A Single Chondroitin 6-Sulfate Oligosaccharide Unit at Ser-2730 of Human Thyroglobulin Enhances Hormone Formation and Limits Proteolytic Accessibility at the Carboxyl Terminus

Marisa Conte, Alessia Arcaro, Daniela D'Angelo et al. Jul 01, 2026 pp. 113172 10.1016/j.jbc.2026.113172

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability

Savroop K. Bhamra, Parineeta Arora, May Liew et al. Jul 01, 2026 pp. 113157 10.1016/j.jbc.2026.113157

Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity

Thi Thanh Quynh Tran, Sacha T. Larda, Cecilia Nieves et al. Jul 01, 2026 pp. 113189 10.1016/j.jbc.2026.113189

Tissue-dependent enzymatic control of N-acetyl-β-alanine by PTER

Ruida Li, Sipei Fu, Zhenyu Lyu et al. Jul 01, 2026 pp. 113191 10.1016/j.jbc.2026.113191

Ganaxolone, an approved therapy for CDKL5-deficiency disorder, is an inhibitor of PTP1B

Imanol Zubiete-Franco, Qingting Hu, Steven R. Alves et al. Jul 01, 2026 pp. 113178 10.1016/j.jbc.2026.113178

Autoinhibition of the mechanosensitive lipid scramblase TMEM63B by its C-terminal tail

Megumi Nishimura, Yugo Miyata, Yu Shiraki et al. Jul 01, 2026 pp. 113223 10.1016/j.jbc.2026.113223