PLoS ONE
Articles in this Issue
Comparison of accumulation and distribution of PEGylated and CD-47-functionalized magnetic nanoporous silica nanoparticles in an in vivo mouse model of implant infection
Introduction Drug targeting using nanoparticles is a much-researched topic. Rapid interactions of nanoparticles with the host’s immune system and clearance from the circulation is a major problem resu...
1p and/or 19q polysomy is an adverse prognostic factor in oligodendrogliomas, and easy to detect by automated FISH
Objective To study the feasibility of automated analysis by FISH technique in the determination of the 1p and/or 19q polysomy in oligodendrogliomas (OGs) and to explore its prognostic value. Methods...
Comparative analysis of lower limb biomechanics during unilateral drop jump landings on even and medially inclined surfaces
Background/purpose Lower limbs biomechanics during unilateral jump landing, a common sports maneuver, is widely studied in research. Most studies used an even surface which may not be ecologically val...
Risk of fragility fracture is aggravated during bone regeneration processes in osteoporotic sheep
Introduction Bone regeneration processes are associated with a systemic skeletal change in bone quality, increasing the risk of fragility fractures. This condition may be aggravated in osteoporotic pa...
Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition
Ado-trastuzumab emtansine (T-DM1), a conjugate of trastuzumab and the cytotoxic agent emtansine, has demonstrated significant antitumor efficacy in HER2-positive (HER2+) carcinoma. However, its effect...
Early empathy development: Concern and comforting in 9- and 18-month-old infants from Uganda and the UK
Empathy, the capacity to share and understand others’ emotional states, is important for navigating our social lives, yet its development in infancy remains poorly understood. Moreover, most research...
Spatial analysis of drug resistant tuberculosis (DRTB) incidence and relationships with determinants in Rio de Janeiro state, 2010 to 2022
Background The aim of this study was to assess the spatial distribution of drug-resistant tuberculosis (DRTB) cases in Rio de Janeiro state and its association with demographics, socioeconomic and hea...
Expression profiling and transcriptional regulation of the SRS transcription factor gene family of common bean (Phaseolus vulgaris) in symbiosis with Rhizobium etli
The SRS/STY transcription factors from the model legumes: Lotus japonicus and Medicago truncatula, are part of regulatory networks that play relevant roles for nodule development during the N-fixing s...
Hematological abnormalities and associated factors among patients with thyroid hormone dysfunction at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Background Thyroid hormones substantially influence the metabolism and production of blood cells; as a result, blood disorders are frequently seen among patients with thyroid hormone disorders. Theref...
Development of a hypoxia-responsive macrophage prognostic model using single-cell and bulk RNA sequencing in pancreatic cancer
Objective Pancreatic ductal adenocarcinoma (PDAC) is characterized by a low survival rate and limited responsiveness to current therapies. The role of hypoxia in the tumor microenvironment is critical...
Can deepfakes manipulate us? Assessing the evidence via a critical scoping review
Deepfakes are one of the most recent developments in misinformation technology and are capable of superimposing one person’s face onto another in video format. The potential of this technology to defa...