PLoS ONE
Articles in this Issue
Cultural adaptation and psychometric validation of the Health Literacy Instrument for Adults with Tuberculosis (HELIA-TB) in India
Background Tuberculosis (TB) remains a critical public health challenge in India, where sustained patient engagement is essential for its effective management. Despite the pivotal...
Extraction and characterization of microcrystalline cellulose from kelp (Laminaria japonica) waste
Kelp, an economically important brown alga widely cultivated in East Asia, produces kelp waste rich in cellulose as a byproduct of alginate extraction. In this study, kelp cellulose (KC) was first ext...
In silico-predicted B-cell epitopes for bovine brucellosis serodiagnosis: Preliminary analytical evaluation of synthetic peptide- and multi-epitope protein-based indirect ELISAs
Serological methods are valuable diagnostic tools for bovine brucellosis, a zoonotic infectious disease with a worldwide distribution. Currently employed diagnostic methods utilize crude bacterial ext...
Editorial Note: Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel
Brucella canis outbreak management towards rehoming strategies: The Italian experience
Canine brucellosis, caused by Brucella canis , is a contagious disease leading to reproductive disorders in both male and female dogs. In April 2020, Italy repo...
AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways
Preeclampsia is a hypertensive disorder of pregnancy marked by angiogenic imbalance and endothelial dysfunction, driven largely by over expression of soluble fms-like tyrosine kinase-1 (sFlt-1) and up...
Invaders taking over—Mollusc faunal change in volcanic barrier lakes of the Albertine Rift biodiversity hotspot
East African freshwater are renowned biodiversity hotspots, particularly within the Rift Valley lakes, which exhibit exceptional species richness and endemism. However, research in this region has pre...
Dosimetric characterization of CdZnTe radiation detectors under electron-beam irradiation
With the growing complexity of modern radiotherapy, the demand for dosimeters capable of delivering real-time, high-resolution, and reliable measurements has grown significantly. Although cadmium–zinc...
Effects of transcutaneous auricular vagus nerve stimulation combined with repetitive facilitative exercise on lower limb motor function in patients with intracerebral hemorrhage: A pilot randomized controlled trial
Objective To evaluate the clinical efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) combined with repetitive facilitative exercise (RFE) in improving lower limb...
Impact of kidney function on the metabolome in the general population
Background A reduction in kidney function cause metabolites that normally are cleared by the kidney to accumulate. These accumulated metabolites could potentially link kidney funct...
Time to maternal death and its predictors among obstetric ICU patients in a resource-limited setting: A 10-year survival analysis
Background Maternal mortality remains a major concern in resource-limited settings, particularly among critically ill obstetric patients requiring intensive care unit (ICU) admissi...
Characterization of entomological drivers of malaria transmission in five villages, Keerom Regency, Papua, Indonesia
Background Keerom Regency remains one of the high-malaria-endemic regencies in Indonesia. Despite the accelerated malaria elimination strategy underway in Papua, malaria transmissi...
Validation of deep learning enabled software MetronMind to measure vertebral heart size and vertebral left atrial size in dogs
Background Vertebral heart size (VHS) and vertebral left atrial size (VLAS) are objective radiographic measurements of heart and left atrial size, respectively and are associated w...
Retraction: Robust policy evaluation from large-scale observational studies
Dual cross-attentive mutual teaching for semi-supervised 3D medical segmentation
Semi-supervised learning can reduce the dependence on large-scale labeled data in 3D medical image segmentation.In this work, we propose a new Dual Crossed Attention Mutual Teaching (DCA-MT) framework...
Spatial characteristics, similarity in business scope, and expansion network of listed companies in China’s food manufacturing industry
Using a multi-source dataset of 777 Listed Companies in the Food Manufacturing Industry (LCFMI), this study examines their spatial and relational organization in China. Key findings are: 1) The geogra...
Dynamic patterns of communication and workload during cardiac surgery: An explorative study
Background Effective communication amongst operating room (OR) teams is crucial for ensuring patient safety and optimizing surgical outcomes. This study aimed to investigate commun...
Short-term rewetting after summer drought does not alter soil fungal community composition and manganese peroxidase activity in managed temperate beech forests
Climate change is increasing the frequency of drought–rewetting cycles in temperate forests, yet the short-term responses of soil fungal communities to these events remain poorly resolved. We investig...
Somatic mutation profiles in aged military nuclear test veterans: A comparative whole-genome sequence study
Veterans of the British nuclear testing programme represent an aged group of ex-military personnel who may have been exposed to ionising radiation through their participation at nuclear testing sites....
The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study
Background Eicosanoids are bioactive signaling lipids that have roles in airway remodeling, smooth muscle hypertrophy, emphysema and pulmonary fibrosis via mediation of pro- and an...
Organizational culture, social capital, and emergency capacity in primary healthcare institutions: A cross-sectional structural equation modeling study comparing ordinary and older communities
The emergency capacity of primary healthcare institutions is critical to the effectiveness of grassroots emergency management. This study examines the relationships among organizational culture, socia...
Lived experiences of diabetes self-management in North Shoa, Ethiopia: A phenomenological inquiry
Background Despite government efforts, diabetes self-management remains inadequate for many patients due to complex barriers. Understanding the lived experiences and barriers to se...
Understanding the “how” and “why”: A mixed methods process evaluation for the PRO-HIIT intervention
Introduction Process evaluation completes outcome evaluation by explaining “how” and “why” an intervention is (in)effective. The aim of this study was to conduct a mixed methods pr...
Whole-genome sequencing reveals a previously unrecognized measles virus cluster in Burundi
Despite remarkable progress towards measles elimination in Burundi, the country has seen a resurge in cases since 2019. Epidemiological investigations have been performed; however, it remained unclear...
The dynamics of innovative behavior in sports professionals: An ecological dynamics approach to the serial mediation of motivation and cognitive flexibility in the influence of perceived social support
This study aims to explain how perceived social support is associated with innovative behavior in sports professionals. The psychological processes explaining this relationship are not sufficiently ex...