PLoS ONE
Articles in this Issue
Integrated transcriptomic and metabolomic analyses reveal the mechanism by which quercetin inhibits reflux esophagitis in rats
Quercetin relieved symptoms in rats with reflux esophagitis (RE), but the underlying mechanism remains unclear. Quercetin attenuated esophageal mucosal inflammation in RE rats by inhibiting the produc...
Protective potential of BM-MSC extracted Exosomes in a rat model of Alzheimer’s disease
Exosomes are extracellular vesicles, which are released into the extracellular space by all types of cells, especially stem cells. Compared with stem cells, exosomes are safer and can be considered on...
Language and family entrepreneurship: empirical research based on micro survey data of CFPS in China
Language serves as a vital link between individuals. In a multi-ethnic country like China, significant differences exist between Standard Mandarin and various regional dialects, which can influence fa...
Compact high-gain circularly polarized patch antenna based on TM30/TM03 mode
This paper presents a circularly polarized (CP) microstrip patch antenna with high gain and compact size characteristics. For high gain radiation, the principle is to employ high-order mode patch. By...
Determinants of household’s dietary diversity during the COVID-19 pandemic: A community-based study in rural Southwestern Bangladesh
Background Inadequate dietary diversity is a significant challenge in public health for low-and middle-income countries, including rural communities in Bangladesh. These issues have intensified and be...
Retraction: Involvement of FOXO Transcription Factors, TRAIL-FasL/Fas, and Sirtuin Proteins Family in Canine Coronavirus Type II-Induced Apoptosis
How do various leadership practices affect professional learning communities? The mediating role of principals’ perceived trust by teachers
Drawing on social exchange theory, this study aims to explore the effects of various leadership practices on professional learning communities (PLCs) and the mediating role of principals’ perceived tr...
Understanding the impact of moxifloxacin on immune function: Findings from cytokine analyses and immunological assays in mice
(1) Background: Moxifloxacin (MXF) is a fluorinated quinolone antibiotic used most commonly due to its broad spectrum of activity. However, the immunomodulatory effects of MXF remain underexplored. Th...
Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer’s disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests
Recent studies have highlighted the significant role of ADAM17/TACE (encoded by ADAM17/TACE) in the pathogenesis of Alzheimer’s disease (AD). Yet, the relationship between ADAM17/TACE gene polymorphis...
Burden and predictors of chronic obstructive pulmonary disease occurrence and severity among an occupational cohort of United States Department of Energy former workers
Background Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease that reduces lung function and primarily affects older adults. Evidence suggests that occupational exposu...
Thermal limits of bumblebees and honeybees are modulated by different functional traits: predictions of a mechanistic model
Local weather conditions are expected to have species specific effects on the activity of insect pollinators. However, the relationship between changing weather patterns and pollinator activity has no...
Did a digital quality of life (QOL) assessment and practice support system in home health care improve the QOL of older adults living with life-limiting conditions and of their family caregivers? A mixed-methods pragmatic randomized controlled trial
We aimed to improve the quality of life (QOL) of homecare patients (≥ 55 years of age) who had chronic life-limiting conditions and that of their family caregivers by making QOL assessment data availa...
Cardio-metabolic traits and its socioeconomic differentials among school children including metabolically obese normal weight phenotypes in India: A post-COVID baseline characteristics of LEAP-C cohort
Background Cardio-metabolic risks emerge in early life and progress further in adult life. In recent times, COVID-19 pandemic aggravated risks owing to poor food security and diet quality. We aimed to...
Effects of biopreparations based on Bacillus and Trichoderma, combined with mineral and organic fertilization and a Pisum sativum L. forecrop on improving the tolerance of Maize plants to drought stress
The increased frequency of extreme weather phenomena, such as heat waves and drought, adversely affects the condition of plants. The need to strive for more sustainable methods of growing plants requi...
Using photovoice to facilitate the report of emotions in an interview setting: An experimental study
Background Finding words to describe emotional experiences can be challenging. Photovoice (PV) represents a possible way of facilitating the report of emotions. In the PV approach, people take picture...
Behavioural analysis of factors influencing prescribing for neurodegenerative diseases: A rapid review
Background The incidence and prevalence of neurodegenerative diseases (NDs) are growing worldwide. In an environment where healthcare resources are already stretched, it is important to optimise treat...
The up-regulation of TGF-β1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages
Although it has been shown that abnormal expression of Wilm’s tumor gene 1 (WT1) is associated with the occurrence of leukemia, the specific mechanism via which it induces leukemia cells to differenti...
Navigating Personalised Support in Universal Credit: Local Support, Care Responsibilities, and Claimant Experiences
This paper investigates the implementation of personalised support under Universal Credit (UC) from both administrative and claimant perspectives, based on qualitative interviews conducted across two...
Transcriptome insights into newcastle disease virus-mediated eradication of cholangiocarcinoma cells
Newcastle Disease Virus (NDV) has emerged as a promising oncolytic viral therapy for various human cancers; however, its effectiveness against cholangiocarcinoma (CCA) remains unexplored. This study p...
Evaluation of Kubuqi Desert Wind Erosion Prevention Service and drivers of the actual wind erosion studies Based on RWEQ Model from 2000 to 2022
Ecosystem service research is essential to identify the contribution of the ecosystem to human welfare. As an important ecological barrier zone, the Kubuqi Desert supports the use of a crucial wind er...
Consumption patterns and eating behaviors of schoolchildren associated with mental health problems: a Brazilian nationwide study
Background Children’s health should be analyzed in a broad context that considers different determinants. Few population-based studies have been conducted, especially with children about food consumpt...
CRISPR genome editing using a combined positive and negative selection system
The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system is a powerful genome editing tool that has revolutionized research. Single nucleotide polymorphisms (SNPs) are the mos...
Hematological changes in the blood of experimental male and female albino rats on exposure to pesticide, dimethoate
Objective Evaluating pesticides’ impacts on human health, ecological balance, and agricultural production is the main focus of research on pesticides. The present study aims to investigate the hematol...
Novel target identification towards drug repurposing based on biological activity profiles
Rare diseases affect more than 30 million individuals, with the majority facing limited treatment options, elevating the urgency to innovative therapeutic solutions. Addressing these medical challenge...
Traffic flow data quality control under video frame rate considering section-level geospatial similarity
The quality of traffic flow data is very important to the effective management and operation of urban traffic system. At present, most traffic flow data used in traffic flow research come from road se...