PLoS ONE
Articles in this Issue
Can kinesio tape negatively affect the treatment by creating a hard floor in plantar fasciitis treatment? A randomized clinical trial
Background Radial extracorporeal shock wave therapy (r-ESWT) is accepted as one of the most effective treatment modalities for plantar fasciitis (PF). Also kinesio taping (KT) applicationis effective...
Development of an LC-MS method for the determination of simvastatin and its hydroxy acid form in muscle tissue and method application
Purpose Statins are the most commonly used drugs worldwide. Besides a significant decrease in cardiovascular diseases (CVDs) risk, the use of statins is also connected with a broad beneficial pleiotro...
Comparative evaluation of two autotransfusion devices in a 72h survival swine model of surgically induced controlled splenic bleeding
Autotransfusion is a key strategy in hemorrhagic surgical procedures, reducing risks like disease transmission and immunosuppression due to allogenic transfusion. While conventional devices efficientl...
Tie-2 regulates endothelial morphological responses to shear stress by FOXO1-triggered autophagy
Introduction Endothelial cells respond to flow-induced shear stress by morphological changes, a process which is important for vascular development and physiology. High laminar shear stress activates...
The value of high-pitch scanning with Sn100kV and ADMIRE in CT examination of tuberculous destroyed lung: Identifying the optimal combination for ultra-low-dose imaging
Objective To investigate the application value of high-pitch scanning combined with energy spectrum purification using Sn100kV and ADMIRE in CT examinations of patients with tuberculous destroyed lung...
Repeatability of biometric measures from the LenStar LS900 in a cataractous population
Purpose To investigate the repeatability of biometric measures and assess interactions between their uncertainties for use in an error propagation model, using patient data. Methods Cross-sectional...
Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse
Human cytomegalovirus (HCMV) has evolved sophisticated strategies to evade host immune defenses, enabling its persistent survival in human populations. HCMV intermediate-early protein 2 (IE2) has been...
Zebrafish do not have a calprotectin ortholog
The protein heterodimer calprotectin and its component proteins, S100A8 and S100A9, play important antibacterial and pro-inflammatory roles in the mammalian innate immune response. Gaining mechanistic...
Urgency enforces stimulus-driven action across spatial and numerical cognitive control tasks
It has been shown that urgency in cognitive control tasks elicits a time-window in which responses are dominated by stimuli rather than goals. If stimulus information conflicts with goal-relevant info...
Self-directed learning in health professions: A mixed-methods systematic review of the literature
Purpose This study investigated the application and effectiveness of various self-directed learning (SDL) models in healthcare organizations. This study aims to identify the prevalent SDL models and f...
Implementation and evaluation of the 3 Wishes Project in safety-net hospitals: Protocol for a hybrid effectiveness-implementation study
Background Palliative care interventions in the intensive care unit have been shown to improve communication and the quality of death and dying. However, few interventions have been implemented in saf...
Enhanced vehicle localization with low-cost sensor fusion for urban 3D mapping
This research paper presents the design and development of an indigenous low cost Mobile Mapping System (MMS) for urban surveying applications. The MMS is comprised of economical Hokuyo-30LX 2D laser...
Latent classes of substance use and delinquency in a Swedish national sample of adolescents and associated risk factors
Background Identifying underlying subgroups might be a way to examine the development of co-occurrent substance use and delinquency. The aim of this study was to identify latent classes of substance m...
Optimization of dual duct forced auxiliary ventilation system to mitigate particulate matter emissions in a polymetallic underground mine environment: A hybrid approach
The auxiliary ventilation system (AVS) is essential for managing airflow and reducing particulate matter (PM) levels in underground mine environments. Despite its importance, prior studies have insuff...
Integration of single-cell and bulk RNA sequencing identifies and validates T cell-related prognostic model in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a lethal malignancy, and predicting patient prognosis remains a significant challenge in clinical treatment. T cells play a crucial role in the tumor microenvironment...
Effect of ozone application on bovine carcasses in abattoir cold chambers
Different technologies have been evaluated to promote food safety and improve the microbiological quality and shelf life of food. The aim of this work was to determine the effect of gaseous ozone on b...
Preparation and characterization of coal-based graphite from Huyan mountain anthracite by high-temperature simulation
This study systematically investigates the graphitization behavior of high-metamorphic anthracite from Huyan Mountain (Shanxi, China) under extreme thermal conditions (2100–3000 °C) through integrated...
The relationship between dementia staging scales, cognitive-behavioral scales and functionality in patients with cognitive impairment
Introduction The aim of this study is to retrospectively evaluate the relationship between dementia stage, cognitive and behavioral scales, and functional status in patients with cognitive impairment....
Exploring canine’s olfactive threshold in artificial urine for medical detection
Canine olfaction is increasingly studied as a tool for detecting cancer and other diseases. Previous pilot studies have demonstrated that dogs can effectively distinguish positive samples from negativ...
Extracellular vesicles therapy alleviates cisplatin-ınduced testicular tissue toxicity in a rat model
Purpose Cisplatin is a commonly used chemotherapy agent effective against various cancers, however it induces significant gonadotoxicity and infertility due to its adverse effects on testicular functi...
Correction: Food security and nutritional vulnerability in Comoros: The impact of Russia-Ukraine conflict
Using of human capital management in small and medium-sized enterprises in context of Industry 4.0
Human capital management (HCM) helps manage and develop human capital (HC) in businesses through investments that increase the value of HC and contribute to improving the financial situation of compan...
Identification of stable reference genes in Edwardsiella ictaluri for accurate gene expression analysis
Edwardsiella ictaluri is a Gram-negative bacterium causing enteric septicemia of catfish (ESC), leading to significant economic losses in the catfish farming industry. RT-PCR analysis is a powerful te...
The impact of the flipped classroom on the motivation and academic performance of Chinese college English learners
The flipped classroom exemplifies the concept of active teaching; nevertheless, its effects on learning motivation and academic performance remain somewhat inconsistent. In this research, a sample of...
Impact of agricultural land use rights transfer on carbon emission intensity of cultivated land--Empirical evidence based on panel data of 30 provinces in China
In the context of high-quality agricultural development, farmers increasingly engage in agricultural land use rights transfer(ALURT) to achieve large-scale operations and improve agricultural producti...