PLoS ONE
Articles in this Issue
Optimal experimental design for partially observable pure birth processes
We develop an efficient algorithm to find optimal observation times by maximizing the Fisher information for the birth rate of a partially observable pure birth process involving n observations. Parti...
Attitudes and opinions of medical practitioners, librarians, and LIS academics towards health science library services to support evidence-based medical practice in South Africa
Background This study explores the attitudes and opinions of health science librarians, university academic staff, and medical practitioners towards health science library services to support Evidence...
Social support and risk perception of influenza among Chengdu residents: A cross-sectional study during post-pandemic recovery
Influenza remains a global public health threat, yet limited evidence exists regarding public risk perception and social support dynamics in post-pandemic contexts. This study investigates the interpl...
Beyond vision: Exploring the impact of visual perception on participation in children with autism spectrum disorder
Visual perception plays a crucial role in the daily participation of children with Autism Spectrum Disorder (ASD) in everyday activities. Exploring the relationship between visual perception skills an...
Ocotillo optimization-driven deep learning for bone marrow cytology classification
Manual diagnosis of hematological cancers like leukemia through bone marrow smear analysis is labor-intensive, prone to errors, and highly dependent on expert knowledge. To overcome these limitations,...
Low-dose aspirin is not effective as an adjunct treatment for HIV infection among people living with HIV on dolutegravir-based antiretroviral therapy: A randomised double-blind, parallel-group placebo-controlled trial
Background Despite virologic suppression with antiretroviral therapy (ART), immune activation (IA) in people living with HIV (PLHIV) remains high and is linked to non-AIDS complications. Alongside its...
Trigeminal nerve stimulation (TNS) for children with attention deficit/hyperactivity disorder and fetal alcohol spectrum disorder: Feasibility study protocol
Symptoms of attention deficit/hyperactivity disorder (ADHD) are common, severe and highly impairing in children with prenatal alcohol exposure (PAE), but often non-responsive to medication, leaving ma...
Age-specific benefits of Vitamin D and its association with mortality
Background Vitamin D is a fat-soluble secosteroid that plays essential roles in calcium homeostasis, bone metabolism, and numerous other physiological processes. Vitamin D deficiency has been associat...
Spatial prediction of canine visceral leishmaniasis in an endemic urban area of Brazil
Canine visceral leishmaniasis (CVL) is a widespread zoonotic disease in Brazil. This study aimed to identify and predict spatial patterns of CVL in an endemic city, Votuporanga, and examine disease as...
Hip, knee, and ankle joint forces during exoskeletal-assisted walking: Comparison of approaches to simulate human-robot interactions
The overall goal of this study was to develop a computational framework to quantify hip, knee, and ankle joint forces during exoskeletal-assisted walking (EAW) in the ReWalk P6.0, an FDA-approved lowe...
Effectiveness of radiofrequency and exercise-based rehabilitation on symptoms associated with pelvic floor dysfunction in breast cancer patients: A study protocol
Background Breast cancer is currently the most diagnosed type of cancer in the world, with a five-year survival rate of 90%. Survivors develop genitourinary dysfunction symptoms due to cancer treatmen...
Prevalence of excess binaural broadband loudness summation in the hearing-impaired population and implications for hearing aid gain targets
Previous studies reported large individual differences in binaural broadband loudness summation in hearing-impaired listeners after narrowband loudness was normalized. These differences in loudness pe...
Exosomal miRNA expression profiling in patients with imatinib resistant Chronic myeloid leukemia: A pilot study
Chronic myeloid leukemia (CML) is a hematologic malignancy originating from hematopoietic stem cells and driven by the BCR-ABL fusion oncogene. Imatinib (IM), a tyrosine kinase inhibitor, is commonly...
Digital product success under the microscope: When artificial intelligence in projects helps — and when it hurts
As organizations navigate an increasingly dynamic digital landscape, the challenge of achieving consistent product success has intensified. This study investigates how key management factors—customer-...
Evaluation of methods for the measurement of antibody-dependent enhancement of dengue virus infection using different FcγRIIa expressing cell lines
Background Pre-existing dengue antibodies could potentially exacerbate disease severity through antibody-dependent enhancement (ADE). Current serological assays focus on measuring neutralizing antibod...
Hybrid adaptive PID control strategy for UAVs using combined neural networks and fuzzy logic
This paper presents a novel hybrid combined neural network and fuzzy logic adaptive proportional, integral, and derivative(NNPID+FPID) control strategy that integrates neural networks and fuzzy logic...
Error recognition of english translation text based on neural network and fuzzy decision tree
In response to the low accuracy and recall of current English translation text error recognition methods, this paper proposes a research on English translation text error recognition based on an impro...
A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Definity
Background Definity significantly enhances the diagnostic accuracy of echocardiography but raises ongoing safety concerns. This study aimed to explore potential adverse events (AEs) associated with De...
LLM-optimized wavelet packet transform for synchronous condenser fault prediction
This paper proposes an innovative approach for predicting faults in synchronous condensers in ultra-high voltage direct current (UHVDC) transmission systems. The framework combines Wavelet Packet Tran...
Gamification-based tele-rehabilitation for physical therapy in patients with Parkinson’s disease: A scoping review
Objective A scoping review was conducted to explore what is known about gamification-based tele-rehabilitation (GBT) to enable physical therapy in home settings for people with Parkinson’s disease (PD...
Assessing fecal pollution source in a Northern Michigan Lake using qPCR and a community-based monitoring framework
Implementing quantitative polymerase chain reaction (qPCR) within a community-based research framework expands the scope and scale of community-driven monitoring and research efforts. The increasing a...
Universal preference for Korean-type grapho-phonemic systematicity: a cross-cultural study of sound-symbol mapping in English, Chinese, and Korean speakers
Recent studies have revealed that writing systems exhibit systematic relationships between letter shapes and their corresponding sounds, termed ‘grapho-phonemic systematicity’. This systematicity mani...
Incidence and progression of diabetic retinopathy and blindness in Indonesian adults with type 2 diabetes
Objectives To report the incidence and progression rate of diabetic retinopathy (DR) and blindness in Indonesian adults with type 2 diabetes....
surveydown: An open-source, markdown-based platform for programmable and reproducible surveys
This paper introduces the surveydown survey platform. With surveydown, researchers can create surveys that are programmable and reproducible using markdown and R code, leveraging the Quarto publicatio...
Global trends in Alzheimer’s disease and other dementias in adults aged 55 and above (1992–2021): An age-period-cohort analysis based on the GBD 2021
Background Alzheimer’s disease and other dementias (ADOD) are growing global health challenges. While existing studies primarily focus on dementia prevention and management in individuals aged 65 and...