PLoS ONE
Articles in this Issue
Retraction: Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined
Noise-Robust image edge detection based on multi-scale automatic anisotropic morphological Gaussian Kernels
This paper presents a novel multi-scale, noise-robust edge detection method that employs multi-scale automatic anisotropic morphological Gaussian kernels to extract edge maps from input images. It add...
Investigating the quaternary structure of a homomultimeric catechol 1,2-dioxygenase: An integrative structural biology study
The structural analysis of catechol 1,2 dioxygenase from Stutzerimonas frequens GOM2, SfC12DO, was conducted using various structural techniques. SEC-SAXS exper...
Epigenetic background of lineage-specific gene expression landscapes of four Staphylococcus aureus hospital isolates
Bacteria with similar genomes can exhibit different phenotypes due to alternative gene expression patterns. In this study, we analysed four antibiotic-resistant Staphylococcus aureus hospital isolates...
Improving fine-grained food classification using deep residual learning and selective state space models
Background Food classification is the foundation for developing food vision tasks and plays a key role in the burgeoning field of computational nutrition. Due to the complexity of food requiring fine-...
5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway
5-O-Methylvisammioside (5OMV), a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, has been shown to inhibit vasospasm induced by High Mobility Group Box 1...
Global burden of ischemic stroke in adults aged 60 years and older from 1990 to 2021: Population-based study
Background Ischemic stroke is an important public health problem. However, comprehensive data on its burden in aging populations is limited. The aim of this study is to provide an up-to-date assessmen...
Automatic diagnostics of electroencephalography pathology based on multi-domain feature fusion
Electroencephalography (EEG) serves as a practical auxiliary tool deployed to diagnose diverse brain-related disorders owing to its exceptional temporal resolution, non-invasive characteristics, and c...
Exploring the drivers of digital transformation in Chinese port and shipping enterprises: A machine learning approach
With the transition to a global green low‐carbon economy, the urgency for digital transformation in the port and shipping industry has become increasingly prominent in making enterprises more efficien...
The epidemiological trends and projected future of primary sclerosing cholangitis by 2040: An updated meta-analysis and modeling study
Background and Aims Primary sclerosing cholangitis (PSC) exhibits varying incidence and prevalence rates across different regions; however, comprehensive global studies examining its geographic distri...
A 10 years update of effects of exercise on depression disorders—in otherwise healthy adults: A systematic review of meta-analyses and neurobiological mechanisms
Background Depression is one of the most common mental illnesses worldwide and is a major burden for those affected. As conventional therapies do not always work and are also assoc...
Coevolution in human small Heat Shock Protein 1 is promoted by interactions between the Alpha-Crystallin domain and the disordered regions
Human small Heat Shock Protein 1 (HSPB1) belongs to the Small Heat Shock Protein (sHSP) superfamily, a group of ATP-independent molecular chaperones essential for cellular stress responses and protein...
Healthcare professionals’ perspectives on barriers and facilitators to implementing a warning signs intervention for older rural-dwelling medical patients at risk for hospital readmission
Introduction Prior research has identified that older rural patients and their families view preparation for detecting and responding to worsening health after a hospital stay as their most pressing u...
Undiagnosed hypertension and associated factors among older adults in Gedeo zone, southern Ethiopia: A mixed methods approach
Background Hypertension often goes undetected for years because its initial symptoms are usually subtle and easily overlooked. Undiagnosed hypertension is a significant contributor to the onset of car...
Identifying candidate items for a health-related quality of life measure in young children with respiratory illness: A scoping review of generic and disease-specific measures
Background Health-related quality of life (HRQoL) in young children affected by respiratory illnesses remains understudied, particularly in low- and middle-income countries (LMICs), where the burden o...
Performance evaluation of therapeutic feeding centers through efficiency, effectiveness and utilization of bed capacity: A retrospective quantitative study
The balance between wise use resources and provision of health services are crucial for the sustainability of services and ensuring value for money. Thus, it is essential to regularly monitor the stat...
Antidiarrheal, analgesic,antidepressant, antimicrobial and hypoglycemic activities of methanolic extract from Sonneratia apetala fruit, with identification of bioactive compounds in n-hexane, chloroform, and ethyl acetate fractions
The rapidly growing mangrove fruit Sonneratia apetala, native to the deltaic region of Bangladesh, holds promise in traditional medicine due to its bioactivity and antimicrobial properties. Sample col...
A synonymous KCNH2 polymorphism and methadone trough level influence QTc prolongation in Kelantanese Malay recipients of methadone maintenance therapy (MMT) in Malaysia
Potassium voltage-gated channel subfamily H member 2 (KCNH2) polymorphisms have been found to influence the heart-rate adjusted QT (QTc) intervals. We investigated the association between KCNH2 polymo...
Analyzing the role of customers’ experiences and emotional responses in shaping Generation Z’s impulse buying behavior on Shopee video platform
The swift growth of e-commerce has markedly changed how consumers shop, especially among Generation Z, which is called Digital Natives. This study examines how product presentation videos on the Shope...
Peracetic acid effects on human bronchial cells in an air liquid interface
Peracetic acid (PAA) is an organic peroxide commonly used as a disinfectant or sterilizing agent across many industries such as in agriculture, water treatment plants, and healthcare facilities. PAA i...
Clinical efficacy and safety of automatic remifentanil administration based on Analgesia Nociception Index monitoring during burn surgery under propofol anesthesia: A randomized controlled clinical trial
Background Monitoring the nociception/antinociception balance for analgesic guidance during general anesthesia may improve the quality of anesthesia. The University Hospital of Lille (France) has deve...
To develop online platform and determine its effectiveness in ENHANCING DIABetes knowledge among diabetes patients in primary CARE clinic (Enhancing-Diab-Care Study): Study protocol
Diabetes Mellitus (DM)- Type 2 is increasingly prevalent in today’s population. DM remains poorly controlled due to insufficient knowledge and understanding of this disease. Maintaining good diabetic...
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes
Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Luminal A and B BC, characterized by estrogen receptor (E...
Family resilience influences on individual physical activity, diet and sleep quality: Family health climate and biobehavioural reactivity as driving mediators
The family is a crucial contributor to mental health and physical well-being. While bidirectional relationships between physical activity, diet, sleep, and mental well-being are well-documented, the i...
Virtual screening and molecular dynamics simulation study of ATP-competitive inhibitors targeting mTOR protein
In order to explore efficient ATP-competitive mTOR inhibitors and aid the development of targeted anticancer drugs, this study focuses on virtual screening and molecular dynamics simulations. The comp...