PLoS ONE
Articles in this Issue
Whether joint leisure time physical activity and dietary quality alleviates metabolic syndrome and its components: evidence from the National Health and Nutrition Examination Survey (2007–2018)
Objectives The incidence of metabolic syndrome (MetS) is increasing, which is one of the major threats to human health. Whether joint leisure time physical activity (LTPA) and dietary quality (DQ) can...
Intraoperative pediatrics hypothermia and its factors during general anesthesia at comprehensive specialized hospitals, Northwest Ethiopia: Multicenter follow up study
Background The human body can regulate its internal temperature under physiological conditions by balancing heat production and loss. Many pediatric patients may experience hypothermia during surgery...
A protocol for a scoping review of variations among psychedelic interventions for psychological suffering associated with the end-of-life
Psychedelic substances are increasingly recognized for their therapeutic potential to ease psychological suffering linked to end-of-life issues. However, amid renewed scientific and public interest, p...
Editorial Note: Development of New Mouse Lung Tumor Models Expressing EGFR T790M Mutants Associated with Clinical Resistance to Kinase Inhibitors
Automatic time in bed detection from hip-worn accelerometers for large epidemiological studies: The Tromsø Study
Accelerometers are frequently used to assess physical activity in large epidemiological studies. They can monitor movement patterns and cycles over several days under free-living conditions and are us...
Workplace diversity in female-dominated industries and intraindividual identity conflict
This research paper examines the impact of gender and socioeconomic status (SES) diversity on intraindividual identity conflict within a female-dominated economic sector. The study also evaluates whet...
Association of the platelet-to-high-density lipoprotein cholesterol ratio (PHR) with metabolic syndrome and metabolic overweight/obesity phenotypes: A study based on the Dryad database
Background Overweight/obesity and metabolic syndrome (MetS) are major global public health challenges. The platelet-to-high-density lipoprotein cholesterol ratio (PHR) has emerged as a potential bioma...
The Welfare versus Work Paradox
How can countries balance work incentives and access to welfare without violating the principle that work shall always be strictly preferred to welfare? In a context in which wages stagnate or drop, a...
Retraction: An immunoinformatics and extended molecular dynamics approach for designing a polyvalent vaccine against multiple strains of Human T-lymphotropic virus (HTLV)
Perceptions of complementary, alternative, and integrative medicine: A global cross-sectional survey of cardiology researchers and clinicians
Background Complementary, alternative, and integrative medicine (CAIM) has been increasing in popularity among patients with cardiovascular illnesses. However, little is known about perceptions of CAI...
Protocol for developing a Consolidated Checklist for Reporting Mixed Methods Research (CORMIX) using modified Delphi
Background Mixed methods research has gained popularity across healthcare and social sciences. However, inconsistent, and inadequate reporting remains a concern, hindering the assessment and utilizati...
The ubiquitin-like modifier FAT10 does not affect IL-12 expression and signaling
The ubiquitin-like modifier FAT10 is strongly expressed in dendritic cells (DCs) and upregulated during inflammation. Interleukin (IL)-12 plays a critical role in promoting CD4+ T cell differentiation...
Retraction: Exploratory algorithms to devise multi-epitope subunit vaccine by examining HIV-1 envelope glycoprotein: An immunoinformatics and viroinformatics approach
Polio vaccination and marginal effects among children aged 12–23 months in Lesotho using 2024 LDHS data: A multilevel analysis approach
Background Infectious diseases that have affected countless newborns, children, and adults can be avoided with polio vaccination. The WHO and Lesotho’s health strategy placed a strong emphasis on vacc...
Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa
Background There is a growing interest in stroke genomics and neurobiobanking research in Africa. These raise several ethical issues, such as consent, re-use, data sharing, storage...
Effects of additional oral theophylline with inhaled therapy in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
The rationale for additional treatment of oral theophylline with inhaled therapy in patients with stable chronic obstructive pulmonary disease (COPD) is unclear. The databases including The Cochrane L...
Associations of multiple trace elements with bipolar disorder in adolescents: A case-control study
Background Bipolar disorder (BD) is a serious mental disorder. Studies have shown an association between trace elements and mental disorders. However, this association has not been thoroughly studied...
Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases
Conditioned medium (CM) derived from human mesenchymal stem cells (MSCs) has shown potential as a therapeutic agent. However, the safety of its administration in human remains largely unexplored. This...
Exploring the mechanisms linking perceived school climate to negative emotions in adolescents: The mediating roles of social avoidance and distress, and psychological resilience, with physical exercise level as a moderator
This study investigates the relationships between perceived school climate (PSC) and negative emotions (NEE) in adolescents, incorporating the mediating roles of social avoidance and distress (SAD) an...
Inverse reconstruction of model cells: Extracting structural and molecular insights through infrared spectroscopic cytology
Infrared (IR) microspectroscopy stands as a transformative clinical tool for analyzing single biological cells in biopsy samples, offering critical insights into their chemical composition. In this st...
Study of the antivirus patch testing problem through optimal control modeling
The lag of antivirus (AV) software development relative to malware development makes it necessary to constantly release AV patches. In practice, an AV patch can be deployed on an organization’s intran...
Application of machine learning in predicting consumer behavior and precision marketing
with the intensification of market competition and the complexity of consumer behavior, enterprises are faced with the challenge of how to accurately identify potential customers and improve user conv...
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone
A hallmark of Alzheimer’s disease (AD) is the extracellular aggregation of toxic amyloid-beta (Aβ) peptides in form of plaques. Here, we identify netoglitazone, an antidiabetic compound previously tes...
Effectiveness over time of a primary series of the original monovalent COVID-19 vaccines in adults in the United States
With data from 2 US claims databases (Optum, CVS Health) supplemented with Immunization Information System COVID-19 vaccine records, we evaluated overall and time-specific vaccine effectiveness (VE) o...
How to implement a clinical ethics committee in an oncological research hospital: Qualitative results from a process evaluation study using normalization process theory (EVACEC)
Introduction The Clinical Ethics Committee (CEC) of the Local Health Authority (LHA) of Reggio Emilia, Italy, is a multi-professional service established in 2020 to support healthcare professionals (H...