PLoS ONE
Articles in this Issue
More than just visits: Timing, frequency, and determinants of effective antenatal care in Bangladesh - BDHS 2007 to 2017-18
Background Timely initiation and adequate number of antenatal care (ANC) visits are crucial for ensuring the health and well-being of both pregnant women and their unborn children. Despite recent prog...
Cardamonin suppresses mTORC1/SREBP1 through reducing Raptor and inhibits de novo lipogenesis in ovarian cancer
Metabolic reprogramming is a hallmark of cancer and de novo lipogenesis (DNL) accelerates the progression of ovarian cancer. In this study, we investigated the effects of cardamonin, a natural compoun...
Service user perspectives and experiences of their diagnosis of psychotic major depression: A qualitative study
Background Evidence suggests psychotic major depression can be overlooked in clinical settings and thus lead to delays in diagnosis. There have been multiple theories about why this happens, however n...
Living with cystic fibrosis during the COVID-19 pandemic: An interpretive description of healthcare access from patients with cystic fibrosis and their providers in Alberta, Canada
Background The current study aimed to explore patient and provider perspectives of the impact of the pandemic on cystic fibrosis healthcare access and service delivery. Methods We used Interpretive...
The Perception of Waiting Times on Patient Satisfaction and Patient Care: A Cross-Sectional Study at a Tertiary Health Care Institution in Kenya
Introduction Patients often spend significant time waiting for care, which influences patient satisfaction, perceived quality, access to care, and utilization of various health care services. Waiting...
Stigma experiences and adaptations in accessing healthcare services among hill tribes in Thailand: A qualitative study
Background One of the significant barriers to accessing healthcare services is the stigma experienced from healthcare workers. Individuals can be significantly impacted by stigma owing to being classe...
CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity
Recombinant interferon alpha (IFNα) has been used to treat cancer patients for over 30 years; however, its clinical utility has been limited by a narrow therapeutic index. Given the recognized anti-tu...
Effects of cold plasma seed treatment on pea (Pisum sativum L.) plant performance under drought and well-watered conditions
Cold plasma (CP) technology is an emerging technology with the potential to enhance agricultural productivity and sustainability. Although its application in crop production is still in the early stag...
Examination of the lung and lymphoid tissue mRNA transcriptome response in dairy calves following experimental challenge with bovine alphaherpesvirus one (BoHV-1)
Bovine alphaherpesvirus one (BoHV-1) is a primary cause of bovine respiratory disease (BRD), and a leading cause of morbidity and mortality in cattle. The transcriptomic responses of key respiratory a...
The Effectiveness of closed kinetic chain exercises in individuals with knee osteoarthritis: A systematic review and meta-analysis
Introduction The aims of this review was to investigate the effectiveness of closed kinetic chain exercise (CKCE) on pain, function, and proprioception in individuals with knee osteoarthritis (OA)....
Comparison of different adjuvant analgesia for paravertebral block in video-assisted thoracoscopic surgery: A double-blind randomized controlled trial
Background Local anaesthetic adjuvants have been shown to provide better pain relief and extend the duration of analgesia. But little information is available on which adjuvants are more effective in...
Traffic accident risk prediction based on deep learning and spatiotemporal features of vehicle trajectories
With the acceleration of urbanization and the increase in traffic volume, frequent traffic accidents have significantly impacted public safety and socio-economic conditions. Traditional methods for pr...
Efficacy of probiotics in patients with cognitive impairment: A systematic review and meta-analysis
Objective To conduct an in-depth exploration of the specific impacts of probiotics and prebiotic supplements on cognitive impairment, it is imperative to also investigate pertinent factors, including...
An image processing technique for optimizing industrial defect detection using dehazing algorithms
In recent years, the demand for efficient and accurate defect detection algorithms in industrial production has been increasing. However, industrial cameras may be affected by water fog during image a...
Investigation of hydrolysis of olmesartan medoxomil in different pH buffers by simultaneously measuring olmesartan medoxomil and olmesartan
Olmesartan medoxomil (OLM) is an ester prodrug of olmesartan (OL) developed to overcome the poor permeability of OL. OLM is an angiotensin receptor blocker and is commonly used to treat hypertension....
The role of the expanded food and nutrition education program in improving healthy eating index scores for low-income households in selected counties in Texas
The Expanded Food and Nutrition Education Program (EFNEP) is a federal initiative aimed at improving the dietary behaviors and nutrition knowledge of low-income households. This study evaluates the im...
IL-18 production is required for the generation of a Th1 response during experimental chromoblastomycosis
Chromoblastomycosis is a chronic fungal infection characterized by the formation of granulomatous lesions in the skin and subcutaneous tissues that begins after inoculation trauma. The disease is more...
German validation of three ethics questionnaires: Consequentialist scale, ethical standards of judgment questionnaire, and revised ethics position questionnaire
Introduction The Consequentialist Scale (CS) and the Ethical Standards of Judgment Questionnaire (ESJQ) are instruments developed to evaluate the extent of moral reasoning in relation to the two pivot...
Spatiotemporal and kinetic characteristics during maximal sprint running in fast running soccer players
This study aimed to elucidate spatiotemporal and kinetic variables in fast-running soccer players in comparison with sprinters or slow-running soccer players. Sixty-seven male soccer players and 17 ma...
Increased serum levels of IL-40 are associated with IgA and NETosis biomarkers in Covid-19 patients: IL-40 and infectious diseases
Interleukin 40 (IL-40) is a novel cytokine that has been associated with B lymphocytes, particularly IgA-secreting cells in gut mucosa. Considering mucosal association of IL-40, we aimed to determine...
Can explainable AI classify shrike (Laniidae) eggs by uncovering species-wide pigmentation patterns?
The complex patterns on bird eggs, characterized by their replicability, distinctiveness, and intricacy, play significant roles in avian biology, including camouflage, protection from brood parasites,...
Perception and management of Oestrus ovis human myiasis by physicians: Exploratory survey in an endemic area (Italy)
Background Myiasis caused by the sheep nasal botfly is endemic in countries where sheep and goats are largely reared, while humans serve as incidental hosts. Ophthalmomyiasis in humans caused by Oestr...
Menstrual cycle and perceived stress predict performance on the mnemonic similarity task
A growing body of literature demonstrates strong effects of ovarian hormones on the hippocampus and adjacent structures. However, resulting impacts on human cognition remain unclear. Addressing this g...
A total-evidence phylogenetic approach to understanding the evolution, depth transitions, and body-shape changes in the anglerfishes and allies (Acanthuriformes: Lophioidei)
The anglerfishes and allies (Lophioidei) are a diverse group of fishes with over 400 carnivorous species that are renowned for their remarkable hunting behavior employing a modified first dorsal-fin s...
A hybrid TCN-XGBoost model for agricultural product market price forecasting
Price volatility in agricultural markets is influenced by seasonality, supply-demand fluctuations, policy changes, and climate. These factors significantly impact agricultural production and the broad...