PLoS ONE
Articles in this Issue
CCR9 shapes the immune microenvironment of colorectal cancer modulating the balance between intratumoral CD8+ T cell and FoxP3+ Helios+ Treg subpopulations
Colorectal cancer (CRC) is the third most common cancer in the world and the second cause of death related to cancer. Regulatory T cell (Treg) infiltration is enriched in several tumor types including...
Economic evaluation of Wolbachia deployment in Colombia: A modeling study
Background and aims Wolbachia are bacteria that inhibit dengue virus replication within the mosquito. A cluster-randomized trial in Indonesia found Wolbachia reduced virologically-confirmed dengue cas...
Prospective follow-up of New York City residents with e-cigarette, or vaping product use-associated lung injury—2020–2021
Background: A multistate outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) occurred in 2019. Because of EVALI’s novelty and severity, the New York City...
Genome-wide association study to identify the genomic loci associated with wheat heading date variation under autumn-sowing conditions
The present study aimed to identify genetic loci associated with days to heading (DTH) in wheat under autumn-sowing conditions in Korea, where early heading is critical owing to the overlap between th...
What’s in a database? Insights from a retrospective review of penguin necropsy records in Aotearoa New Zealand
Wildlife necropsy databases often provide data for morbidity and mortality studies of free-ranging species, with implicit relevance for conservation goals, as well as domestic animal and human health....
Control signal dimensionality depends on limb dynamics
Neural control of movement has to overcome the problem of redundancy in the multidimensional musculoskeletal system. The problem can be solved by reducing the dimensionality of the control space of mo...
Concurrent listening impairs compensatory postural control mechanisms in middle and late adulthood
Multitasking involving sensorimotor functions has been shown to affect older more than young adults but little is known about whether related challenges already emerge in middle adulthood. Here we com...
Association between varicose veins and occurrence of dementia: A nationwide population-based cohort study
While varicose vein (VV) and dementia are frequent health problems, research investigating association between these conditions has been limited. We aimed to investigate the relationship between the p...
Patient satisfaction with general practice in Scotland 2011/12 to 2021/22
Background The Scottish Government introduced the first phase of a new General Practice (GP) contract in 2018, aiming to transform primary care and address health inequalities. However, the impact of...
The ‘side effects’ of digitalization: A study on role overload and job burnout of employees
In the context of the digital economy, enterprise digitalization represents a significant opportunity to enhance core competitiveness. Nevertheless, the digitalization of enterprises may have unantici...
The impact of missing data rates and imputation methods on the assumption of unidimensionality
Statistical models are essential tools in data analysis. However, missing data plays a pivotal role in impacting the assumptions and effectiveness of statistical models, especially when there is a sig...
Modeling land use and land cover dynamics of Bale Mountains National Park using Google Earth Engine and cellular automata–artificial neural network (CA-ANN) model
This research aimed to assess the observed land use and land cover (LULC) changes of Bale Mountains National Park (BMNP) from 1993 to 2023 and its future projections for the years (2033 and 2053). The...
Improved siamese tracking for temporal data association
Temporal image data association is essential for visual object tracking tasks. This association task is typically stated as a process of connecting signals from the same object at different times alon...
Side effects may include: Consequence neglect in generating solutions
Strategies designed to address specific problems often give rise to unintended, negative consequences that, while foreseeable, are overlooked during strategy formulation and evaluation. We propose tha...
The influence of after-school tutoring on the mental health of middle school students: A mediating effect test based on sleep deprivation and academic performance
Although Western studies have shown that adolescents’ mental health is intimately linked to after-school tutoring, very few studies have addressed this issue among Chinese adolescents. Herein, this st...
Building inclusive rehabilitation education: A scoping review protocol on EDI approaches and impact
Introduction Equity, diversity, and inclusion (EDI) interventions are critical in fostering accessible and supportive educational environments in rehabilitation professions such as physiotherapy, occu...
Correction: Conjectures and refutations: Species diversity and phylogeny of Australoheros from coastal rivers of southern South America (Teleostei: Cichlidae)
The ultimate challenge to climate change: Endurance of a thermophilic reptile to the harsh temperatures on an extremely hot island
Herbivorous ectotherms are especially vulnerable to climate change and those inhabiting hot environments may already live near their maximum physiological limits. Insular species are particularly susc...
Photosynthetic response and agronomic performance of maize intercropped with beans using different planting patterns and fertilizers under the ambient conditions of the Colombian Amazon
Small holders in the Colombian Amazon region use maize-bean intercropping for improving productivity under the combined stress conditions of acidic soils and high temperature. This study is aimed to e...
Characterization and whole genome sequencing of Saccharomyces cerevisiae strains lacking several amino acid transporters: Tools for studying amino acid transport
Saccharomyces cerevisiae mutants have been used since the early 1980s as a tool for characterizing genes from other organisms by functional complementation. This approach has been extremely successful...
Threshold fertility for the avoidance of extinction under critical conditions
The developed countries now face a low fertility crisis. The replacement level fertility (RLF) is conventionally considered to be 2.1 children per woman, in which demographic stochasticity arising fro...
Effects of supplemental hybrid bacterial 6-phytase in low-energy, inorganic phosphorus-free hen diets on laying performance, egg quality, and bone strength
A 22-week trial was conducted to assess the effects of replacing inorganic phosphorus (P) with two levels of a hybrid bacterial 6-phytase in low-energy diets for laying hens, from 23 to 44 weeks of ag...
Identification and functional analysis of five hub lncRNAs associated with oncogenesis of Hepatocellular Carcinoma
Liver cancer stands as one of the most pervasive and aggressive malignant neoplasms on a global scale, with hepatocellular carcinoma (HCC) accounting for over 90% of primary liver cancer cases. It has...
Clinical assessment of the criticality index – dynamic, a machine learning prediction model of future care needs in pediatric inpatients
Objective To assess patient characteristics and care factors that are associated with correct and incorrect predictions of future care locations (ICU vs. non-ICU) by the Criticality Index-Dynamic (CI-...
Domestic laundering of healthcare textiles: Disinfection efficacy and risks of antibiotic resistance transmission
Hospital-acquired infections (HAIs) and antimicrobial resistance (AMR) are a major public health concern, with the evidence base for the potential role of textiles as fomites in microbial transmission...