Journal of Biological Chemistry

PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells

Yue Huang, Yuting Zhang, Yuan Liu et al. Jan 01, 2025 pp. 108111 10.1016/j.jbc.2024.108111

Phosphorylation of Ephexin4 at Ser-41 contributes to chromosome alignment via RhoG activation in cell division

Ryuji Yasutake, Hiroki Kuwajima, Ryuzaburo Yuki et al. Jan 01, 2025 pp. 108084 10.1016/j.jbc.2024.108084

The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery

Pavel Novotný, Jana Humpolíčková, Veronika Nováková et al. Jan 01, 2025 pp. 108079 10.1016/j.jbc.2024.108079

A kinetic model for compound heterozygous pathogenic variants in Tyrosyl-tRNA synthetase gene YARS2-Associated neonatal phenotype

Thomas Christian, Sunita Maharjan, Sitao Yin et al. Jan 01, 2025 pp. 108092 10.1016/j.jbc.2024.108092

The transcription factor CREB regulates epithelial-mesenchymal transition of lens epithelial cells by phosphorylation-dependent and phosphorylation-independent mechanisms

Lan Zhang, Jing-Miao Wang, Ling Wang et al. Jan 01, 2025 pp. 108064 10.1016/j.jbc.2024.108064

p38α and p38β regulate osmostress-induced apoptosis

Nabil Ben Messaoud, José M. López Jan 01, 2025 pp. 108061 10.1016/j.jbc.2024.108061

An oncoprotein CREPT functions as a co-factor in MYC-driven transformation and tumor growth

Mengdi Li, Jingya Li, Chunhua He et al. Jan 01, 2025 pp. 108030 10.1016/j.jbc.2024.108030

Epitope mapping via in vitro deep mutational scanning methods and its applications

Meredith M. Keen, Alasdair D. Keith, Eric A. Ortlund Jan 01, 2025 pp. 108072 10.1016/j.jbc.2024.108072

Targeting cytoskeletal biomechanics to modulate airway smooth muscle contraction in asthma

Morgan McCullough, Ilin V. Joshi, Nicolas L. Pereira et al. Jan 01, 2025 pp. 108028 10.1016/j.jbc.2024.108028

Epigenetic activation of JAG1 by AID contributes to metastasis of hepatocellular carcinoma

Junna Jiao, Kun Shao, Zixian Liu et al. Jan 01, 2025 pp. 108078 10.1016/j.jbc.2024.108078

Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326

Maria Georgieva, Filip Stojceski, Fabian Wüthrich et al. Jan 01, 2025 pp. 108018 10.1016/j.jbc.2024.108018

Withdrawal: Neutralization of RANTES and eotaxin prevents the loss of dopaminergic neurons in a mouse model of Parkinson disease

Goutam Chandra, Suresh B. Rangasamy, Avik Roy et al. Jan 01, 2025 pp. 108102 10.1016/j.jbc.2024.108102

Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels

Fang Wang, Baoqiang Wang, Xiwei Gu et al. Jan 01, 2025 pp. 108023 10.1016/j.jbc.2024.108023

Multiple gating processes associated with the distal end of the S6 segment of domain II in the Nav channels

Minzhi Chen, Shuijiao Peng, Zhen Xiao et al. Jan 01, 2025 pp. 108060 10.1016/j.jbc.2024.108060

Dysregulation of PI4P in the trans Golgi regions activates the mammalian Golgi stress response

Kanae Sasaki, Marika Toide, Takuya Adachi et al. Jan 01, 2025 pp. 108075 10.1016/j.jbc.2024.108075

Unveiling 14 novel 2-hydroxy acid racemization and epimerization reactions in the lactate racemase superfamily

Julian Urdiain-Arraiza, Amandine Vandenberghe, Gergana Dimitrova et al. Jan 01, 2025 pp. 108069 10.1016/j.jbc.2024.108069

Histone variants: The bricks that fit differently

Youssef A. Hegazy, Hejer Dhahri, Nour El Osmani et al. Jan 01, 2025 pp. 108048 10.1016/j.jbc.2024.108048

Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease

Tegan McTaggart, Jing Xuan Lim, Katie J. Smith et al. Jan 01, 2025 pp. 108059 10.1016/j.jbc.2024.108059

Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist

Trung Thach, KanagaVijayan Dhanabalan, Prajwal Prabhakarrao Nandekar et al. Jan 01, 2025 pp. 108109 10.1016/j.jbc.2024.108109

E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2

Tianyi Wu, Fengli Jiang, Fan Wu et al. Jan 01, 2025 pp. 108027 10.1016/j.jbc.2024.108027

The mechanism of Ca2+-independent activation of BKCa channels in mouse inner hair cells and the crucial role of the BK channels in auditory perception

Zhong-Shan Shen, Jun Gan, Bing Xu et al. Jan 01, 2025 pp. 107970 10.1016/j.jbc.2024.107970

Quiescent cells maintain active degradation-mediated protein quality control requiring proteasome, autophagy, and nucleus-vacuole junctions

Dina Franić, Mihaela Pravica, Klara Zubčić et al. Jan 01, 2025 pp. 108045 10.1016/j.jbc.2024.108045

Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells

Manon Garcia, Hélène Holota, Angélique De Haze et al. Jan 01, 2025 pp. 108022 10.1016/j.jbc.2024.108022

An anomalous abundance of tryptophan residues in ceramide synthases based on analysis of all membrane proteins in the Swiss-Prot database

Beatriz Mestre, Iris D. Zelnik, Stav Izrailov et al. Jan 01, 2025 pp. 108053 10.1016/j.jbc.2024.108053

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Thomas C. Eadsforth, Leah S. Torrie, Paul Rowland et al. Jan 01, 2025 pp. 108049 10.1016/j.jbc.2024.108049