Journal of Biological Chemistry

Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding

Yufan He, Nikita Zalenski, Anthony A. Stephenson et al. Feb 01, 2025 pp. 108120 10.1016/j.jbc.2024.108120

P300/RNA polymerase II mediates induction of the teleost viral RNA sensor MDA5 through the interferon regulatory factor IRF11

Wenxing Li, Yuan Feng, Yan Teng et al. Feb 01, 2025 pp. 108193 10.1016/j.jbc.2025.108193

Diet-induced obesity mediated through estrogen-related receptor α is independent of intestinal function

Kiranmayi Vemuri, Jahangir Iqbal, Sneha Kumar et al. Feb 01, 2025 pp. 108197 10.1016/j.jbc.2025.108197

Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5

Cyrus Y. Jin, Moritz Hunkeler, Kathleen M. Mulvaney et al. Feb 01, 2025 pp. 108165 10.1016/j.jbc.2025.108165

Cysteine import via the high-affinity GSH transporter Hgt1 rescues GSH auxotrophy in yeast

Crystal C. McGee, Tirthankar Bandyopadhyay, Cailin N. McCracken et al. Feb 01, 2025 pp. 108131 10.1016/j.jbc.2024.108131

Crucial role and conservation of the three [2Fe-2S] clusters in the human mitochondrial ribosome

Linda Boß, Oliver Stehling, Hans-Peter Elsässer et al. Feb 01, 2025 pp. 108087 10.1016/j.jbc.2024.108087

Inositol phosphates dynamically enhance stability, solubility, and catalytic activity of mTOR

Lucia E. Rameh, John D. York, Raymond D. Blind Feb 01, 2025 pp. 108095 10.1016/j.jbc.2024.108095

The cobalamin processing enzyme of Trichoplax adhaerens

Caroline Krams, Anna J. Esser, Melissa Klenzendorf et al. Feb 01, 2025 pp. 108089 10.1016/j.jbc.2024.108089

Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase

Ilka Keller, Ádám Ungvári, Evelin Major et al. Feb 01, 2025 pp. 108107 10.1016/j.jbc.2024.108107

Familial Alzheimer’s disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors

Steven J. Tavalin Feb 01, 2025 pp. 108147 10.1016/j.jbc.2024.108147

Acute heat stress upregulates Akr1b3 through Nrf-2 to increase endogenous fructose leading to kidney injury

Shuai Wang, Xuan Pang, Yujuan Cai et al. Feb 01, 2025 pp. 108121 10.1016/j.jbc.2024.108121

Prenylation-dependent membrane localization of a deubiquitinating enzyme and its role in regulating G protein–mediated signaling in yeast

Fangli Weng, Xin Jin, Sindhu Ragunathan et al. Feb 01, 2025 pp. 108180 10.1016/j.jbc.2025.108180

Redox potential tuning by calcium ions in a novel c-type cytochrome from an anammox organism

Mohd. Akram, David Hauser, Andreas Dietl et al. Feb 01, 2025 pp. 108082 10.1016/j.jbc.2024.108082

Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades

Reuben J. Peters Feb 01, 2025 pp. 108142 10.1016/j.jbc.2024.108142

Disorder within order: Identification of the disordered loop of STAS domain as the inhibitory domain in SLC26A9 chloride channel

An-Ping Chen, Heather Holmes, James W. Decker et al. Feb 01, 2025 pp. 108145 10.1016/j.jbc.2024.108145

Substrate and inhibitor specificity of Plasmodium nucleoside transporters ENT1 orthologs

Xinyi Chen, Chengyu Tian, Yingying He et al. Feb 01, 2025 pp. 108115 10.1016/j.jbc.2024.108115

SF3B1 thermostability as an assay for splicing inhibitor interactions

Angela N. Amorello, Guddeti Chandrashekar Reddy, Bruno Melillo et al. Feb 01, 2025 pp. 108135 10.1016/j.jbc.2024.108135

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium

Sean R. Cleary, Allen C.T. Teng, Audrey Deyawe Kongmeneck et al. Feb 01, 2025 pp. 108118 10.1016/j.jbc.2024.108118

Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability

Jessica R. Bobbitt, Leslie Cuellar-Vite, Kristen L. Weber-Bonk et al. Feb 01, 2025 pp. 108196 10.1016/j.jbc.2025.108196

Recent advances in the synthesis and application of biomolecular condensates

Zhongyue Li, Wei Tan, Guo-ping Zhao et al. Feb 01, 2025 pp. 108188 10.1016/j.jbc.2025.108188

Imaging-based quantitative assessment of biomolecular condensates in vitro and in cells

Tessa Bergsma, Anton Steen, Julia L. Kamenz et al. Feb 01, 2025 pp. 108130 10.1016/j.jbc.2024.108130

Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament

Felipe Montecinos, Elif Eren, Norman R. Watts et al. Feb 01, 2025 pp. 108132 10.1016/j.jbc.2024.108132

Laser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons

Balázs Göcz, Éva Rumpler, Soma Szentkirályi-Tóth et al. Feb 01, 2025 pp. 108150 10.1016/j.jbc.2024.108150

Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability

Jessica do Nascimento Faria, Amanda G. Eufrásio, Michelle Fagundes et al. Feb 01, 2025 pp. 108080 10.1016/j.jbc.2024.108080

Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond

Tijn T. van der Velden, Kanwal Kayastha, Caspar Y.J. Waterham et al. Feb 01, 2025 pp. 108094 10.1016/j.jbc.2024.108094