Journal of Biological Chemistry

Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons

Kévin Leguay, Mariana Acevedo, Eva Colic et al. Jul 01, 2025 pp. 110341 10.1016/j.jbc.2025.110341

Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase

Gundeep Kaur, John R. Horton, George Tzertzinis et al. Jul 01, 2025 pp. 110357 10.1016/j.jbc.2025.110357

Bacterial genome-encoded ParMs

Samson Ali, Adrian Koh, David Popp et al. Jul 01, 2025 pp. 110351 10.1016/j.jbc.2025.110351

ATPase-dependent duplex nucleic acid unwinding by SARS-CoV-2 nsP13 relies on facile binding and translocation along single-stranded nucleic acid

Jinwoo Park, Yong-Joo Jeong, Khushbu Chauhan et al. Jul 01, 2025 pp. 110373 10.1016/j.jbc.2025.110373

Dimerization of the BAR domain–containing protein FAM92A modulates lipid binding and interaction with CBY1

Xiaohan Xu, Jing Ren, Jianchao Li Jul 01, 2025 pp. 110346 10.1016/j.jbc.2025.110346

Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia

Xu Sang, Yanchun Guan, Mengying Jiang et al. Jul 01, 2025 pp. 110321 10.1016/j.jbc.2025.110321

Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum

Taeyeop Park, Katherine Forbush, Yong Li et al. Jul 01, 2025 pp. 110317 10.1016/j.jbc.2025.110317

A versatile fluorescence polarization-based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)

Jiatong Zhang, Jed Allen, Stephanie J. Ward et al. Jul 01, 2025 pp. 110342 10.1016/j.jbc.2025.110342

Select early growth response (Egr) isoforms augment hypoxia inducible factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals

Jason S. Nagati, Elhadji M. Dioum, Catarina S. Giardinetto et al. Jul 01, 2025 pp. 110355 10.1016/j.jbc.2025.110355

Regulatory helix plays a key role in genetic ON–OFF switching for the 2′-deoxyguanosine-sensing mRNA element

Susmit Narayan Chaudhury, Nathan Edward Jespersen, Scott P. Hennelly et al. Jul 01, 2025 pp. 110282 10.1016/j.jbc.2025.110282

NDRG1 and its family members: More than just metastasis suppressor proteins and targets of thiosemicarbazones

Mahan Gholam Azad, Tiffany M. Russell, Xuanling Gu et al. Jul 01, 2025 pp. 110230 10.1016/j.jbc.2025.110230

Phosphorylation of syntenin-1 by TBK1 promotes proliferation and migration of non-small cell lung cancer cells

Lin Gao, Hecun Zou, Guojiao Xie et al. Jul 01, 2025 pp. 110278 10.1016/j.jbc.2025.110278

The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation

Arkajit Guha, Ruma Banerjee Jul 01, 2025 pp. 110366 10.1016/j.jbc.2025.110366

Cytochrome P450BM-3 and P450 11A1 retain Compound I (FeO3+) chemistry with electrophilic substrates poised for Compound 0 (Fe3+O2−) reactions

Kevin D. McCarty, Yasuhiro Tateishi, F. Peter Guengerich Jul 01, 2025 pp. 110378 10.1016/j.jbc.2025.110378

Biochemical and structural characterization of a GNAT superfamily protein acetyltransferase from Helicobacter pylori

Venkatareddy Dadireddy, Amrendra Kumar, Sumith Kumar et al. Jul 01, 2025 pp. 110356 10.1016/j.jbc.2025.110356

Topological isomers of a potent wound healing peptide: Structural insights and implications for bioactivity

Tiziano Raffaelli, David T. Wilson, Mehdi Mobli et al. Jul 01, 2025 pp. 110340 10.1016/j.jbc.2025.110340

Structural basis for sirtuin 2 activity and modulation: Current state and opportunities

Samuel P. Bernhard, Francesc X. Ruiz, Stacy Remiszewski et al. Jul 01, 2025 pp. 110274 10.1016/j.jbc.2025.110274

Evaluation of AlphaFold modeling for elucidation of nanobody–peptide epitope interactions

Shivani Sachdev, Swarnali Roy, Shubhra J. Saha et al. Jul 01, 2025 pp. 110268 10.1016/j.jbc.2025.110268

Molecular mechanism of antagonist recognition and regulation of the α1A-adrenoceptor

Sisi Liu, Haizhan Jiao, Yuyong Tao et al. Jul 01, 2025 pp. 110348 10.1016/j.jbc.2025.110348

USP25 maintains KRAS expression and inhibiting the deubiquitinase suppresses KRAS signaling in human cancer

Huailu Ma, Huiyuan Guan, Xiao Sun et al. Jul 01, 2025 pp. 110337 10.1016/j.jbc.2025.110337

Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway

Shu Yang, Heming Huang, Kewei Jiang et al. Jul 01, 2025 pp. 110381 10.1016/j.jbc.2025.110381

A novel compound DBZ alleviates chronic inflammatory pain and anxiety-like behaviors by targeting the JAK2-STAT3 signaling pathway

Bao Sun, Mengyao Wu, Yilin Ru et al. Jul 01, 2025 pp. 110223 10.1016/j.jbc.2025.110223

High-throughput epigenetic profiling immunoassays for accelerated disease research and clinical development

Priscilla Van den Ackerveken, Clotilde Hannart, Dorian Pamart et al. Jul 01, 2025 pp. 110352 10.1016/j.jbc.2025.110352

Map of the neuronal O-glycoproteome reveals driver functions in the regulated secretory pathway

Thomas D. Madsen, Asli B. Topaktas, Leo A. Dworkin et al. Jul 01, 2025 pp. 110313 10.1016/j.jbc.2025.110313

Functional genomics and structural insights into maize aldo-keto reductase-4 family: Stress metabolism and substrate specificity in embryos

Sylvia Morais de Sousa, Priscila Oliveira de Giuseppe, Mario Tyago Murakami et al. Jul 01, 2025 pp. 110404 10.1016/j.jbc.2025.110404