Journal of Biological Chemistry

Reconstituted ferredoxin–MEP pathway of Apicomplexa in Escherichia coli as an in situ screening platform for inhibitors and essential enzyme mutations

Ojo-Ajogu Akuh, Deborah Maus, Martin Blume et al. Nov 01, 2025 pp. 110726 10.1016/j.jbc.2025.110726

Cryo-EM study and in vivo chemical mapping of the Methanosarcina acetivorans ribosome and its dimerization via a repurposed enzyme and translation factor

George N.R. Fordjour, Anwesha Ghosh, James G. Ferry et al. Nov 01, 2025 pp. 110686 10.1016/j.jbc.2025.110686

A shared basis for nutrient limitation response in cyanobacteria

Hagit Zer, Stav Chen, David Rasin et al. Nov 01, 2025 pp. 110765 10.1016/j.jbc.2025.110765

Rules of engagement: Determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

Mian Huang, Aura F. Celniker, Rezvan Chitsazi et al. Nov 01, 2025 pp. 110736 10.1016/j.jbc.2025.110736

Nitric oxide regulates cytochrome P450 2D6 and 3A4 activity via concentration-dependent modulation of heme loading

Priya Das Sinha, Sidra Islam, Pranjal Biswas et al. Nov 01, 2025 pp. 110772 10.1016/j.jbc.2025.110772

Intrinsically disordered cytoplasmic tail in netrin receptor DCC binds the large ribosomal subunit to inhibit translation

Natasia Paukovich, Elizabeth A. Spear, Andrea MacFadden et al. Nov 01, 2025 pp. 110741 10.1016/j.jbc.2025.110741

Mechanistic coupling of enzymatic activities at the replisome

Malisha U. Welikala, Lauren J. Butterworth, Rashini Y. Beragama Arachchi et al. Nov 01, 2025 pp. 110761 10.1016/j.jbc.2025.110761

Spectroscopic insights into the mechanism of anammox hydrazine synthase

Wouter Versantvoort, Rainer Hienerwadel, Christina Ferousi et al. Nov 01, 2025 pp. 110771 10.1016/j.jbc.2025.110771

IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis

Yu Li, Dongyue Liu, Shuangxi Li Nov 01, 2025 pp. 110764 10.1016/j.jbc.2025.110764

Deciphering mutational effects on inducible NO synthase conformational dynamics via quantitative cross-linking mass spectrometry and AlphaFold2 subsampling

Ting Jiang, Haikun Zhang, Gabriel Monteiro Da Silva et al. Nov 01, 2025 pp. 110673 10.1016/j.jbc.2025.110673

Variation in type IV pilus stability modulates DNA uptake and biofilm formation

Yafan Yu, Rabab Mahdi, Ahmad Al-Hilfy Leon et al. Nov 01, 2025 pp. 110787 10.1016/j.jbc.2025.110787

Direct coupling of lactate oxidation with butyryl-CoA formation via a canonical electron transfer flavoprotein in Fusobacterium nucleatum

Long T.M. Do, Robert Godin, Kirsten R. Wolthers Nov 01, 2025 pp. 110796 10.1016/j.jbc.2025.110796

Identification and rescue of congenital hyperinsulinism-associated ABCC8 mutations that impair KATP channel trafficking

Assmaa ElSheikh, Yi-Ying Kuo, Kara E. Boodhansingh et al. Nov 01, 2025 pp. 110779 10.1016/j.jbc.2025.110779

SLC39A5 promotes the malignant progression of gastric cancer by activating BATF phosphorylation

Xinyu Wang, Tao Li, Mingxi Xia et al. Nov 01, 2025 pp. 110754 10.1016/j.jbc.2025.110754

Understanding O-GlcNAc transferase (OGT): Every amino acid matters

Ningda Xu, Yucheng Zhao, Wei Chi et al. Nov 01, 2025 pp. 110760 10.1016/j.jbc.2025.110760

Loss of TRIM44 promotes renal cell carcinoma progression by regulating K48-linked ubiquitination of vimentin

Ke Shi, Baiyun Jia, Yuanyu Li et al. Nov 01, 2025 pp. 110734 10.1016/j.jbc.2025.110734

Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase

Eric Z. Pang, Boyu Zhao, Cameron Flowers et al. Nov 01, 2025 pp. 110735 10.1016/j.jbc.2025.110735

Differential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations

Linda Geiges, Tobias Staudner, Juthamas Khamseekaew et al. Nov 01, 2025 pp. 110766 10.1016/j.jbc.2025.110766

APP family is a regulator of endo-lysosomal membrane vulnerability

Brianna Lundin, Natalia Wieckiewicz, Midori Yokomizo et al. Nov 01, 2025 pp. 110774 10.1016/j.jbc.2025.110774

Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1)

Dong Yan Zhang, Jian Wang, Gangtong Huang et al. Nov 01, 2025 pp. 110778 10.1016/j.jbc.2025.110778

The complex network of p300/CBP regulation: Interactions, posttranslational modifications, and therapeutic implications

Ebru Yazıcı, Justyna McIntyre Nov 01, 2025 pp. 110715 10.1016/j.jbc.2025.110715

Generation of NADPH and the formation of lipofuscin fluorophore precursors in human rod photoreceptors

Leopold Adler, Chunhe Chen, Nicholas P. Boyer et al. Nov 01, 2025 pp. 110802 10.1016/j.jbc.2025.110802

Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids

Matthew L. Edin, Joan P. Graves, Darryl C. Zeldin Nov 01, 2025 pp. 110737 10.1016/j.jbc.2025.110737

USP52 inhibits cell ferroptosis via Hippo–YAP pathway and blocks immunotherapy in colorectal cancer

Jingkai Zhou, Haihang Nie, Chenhui Liu et al. Nov 01, 2025 pp. 110725 10.1016/j.jbc.2025.110725

NR4A1 is a HIF-dependent repressor of SLC30A10 transcription that controls manganese homeostasis

Noah R. Haggerty, Yeo Rang Lee, Nishant Sharma et al. Nov 01, 2025 pp. 110707 10.1016/j.jbc.2025.110707