PLoS ONE
Articles in this Issue
Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis
While numerous studies have extensively documented the pleiotropic effects of statins, including their capacity to reduce inflammation, there is a lack of research estimating the anti-inflammatory eff...
The effect of arsenic on mitochondrial fatty acid metabolism via inhibition of carnitine palmitoyltransferase 1B and choline kinase beta in C2C12 cells
Arsenic can enter the human body through environmental exposure via food, drinking water, and chemotherapy for cancer. Prolonged and excessive exposure to arsenic causes various toxic reactions, leadi...
HIV protease inhibitors restore amphotericin B activity against Candida
Candida auris is an invasive fungal pathogen, representing a global public health threat. It is characterized by high mortality rates among infected individuals, significant antifungal resistance, and...
Health inequity: Possibilities of initiating pulmonary telerehabilitation programs for adults with chronic obstructive pulmonary disorders in conflict and low-resourced areas; A mixed-method phenomenological study
Objective The “triple problems of COPD”—underdiagnosis, underrecognition, and underdevelopment of pulmonary rehabilitation programs—are global. Pulmonary telerehabilitation (PTR) may solve these probl...
Different paths, same destination, yet diverse effects: Antecedent configurations and performance implications of digital transformation in pharmaceutical manufacturing enterprises——Evidence from Chinese listed companies
The empowerment of the real economy through digital technology has emerged as a crucial force in driving enterprises toward high-quality development. Identifying effective strategies to accelerate the...
Saliva urea nitrogen for detection of kidney disease in adults: A meta-analysis of diagnostic test accuracy
Background Kidney disease affects millions globally, especially in low and middle-income countries where access to diagnostic testing is limited. Saliva urea nitrogen (SUN) has been proposed as a simp...
AI powered ELT: Instructors’ transformative roles and opportunities
The integration of artificial intelligence (AI) in education is reshaping English language teaching (ELT), redefining the ‘assistant’ function of technology and the ‘interaction’ roles of language ins...
The complex impact of China’s science and technology talent policies on key core technologies R&D
Key core technologies have become the focal point of global technological competition. For latecomer countries, formulating effective science and technology talent policies to stimulate researchers’ m...
Experimental device to measure the compressibility coefficient of soft materials
At present, there are many ways to measure the compressibility coefficient of a sample, but none of them allow the measurement of compressibility on samples that cannot be cut to a precise shape, such...
5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent
Drug resistance is a growing problem for many pathogens, including mycobacteria. Small heterocyclic molecules are among the leading scaffolds for developing potential antimycobacterial agents. Therefo...
Wrist-ankle acupuncture alleviates pain in the acute phase of herpes zoster: A randomized controlled trial
Alternative therapeutic strategies for herpes zoster, especially for acute phase pain relief, are still largely unexplored. This study aimed to compare the effects of wrist-ankle acupuncture combined...
Cell death and iron deposition in the liver in two murine models of acute radiation syndrome
Different tissues exhibit differential sensitivity to ionizing radiation exposure and display different time courses of pathologies that are not well understood. Ionizing radiation causes hemolysis of...
Postpartum hemorrhage incidence and risk factors: Evidence from a multicenter study in Zhejiang Province, China
Objective Postpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide, and its risk factors vary regionally. This study assessed the incidence and determinants of PPH in Zhejiang Pr...
An improved modeling approach to investigate biases in human random number generation
Recently, a novel computational model was proposed to investigate the processes and biases involved in human random number generation (RNG). This two-parameter model includes a repetition parameter an...
Research on identity authentication and data security of photovoltaic power generation management personnel based on blockchain technology
As high-frequency technological developments happen and the variety of Microgrids (MG) grows, microgrids are going to be able to secure their own usage while competing in the electricity sector. To op...
Spatial interpolation of health and demographic variables: Predicting malaria indicators with and without covariates
Accurate mapping and disaggregation of key health and demographic risk factors have become increasingly important for disease surveillance, which can reveal geographical social inequalities for improv...
A cross-sectional study of factors influencing sexual health among spouses of patients with cervical cancer
Background After treatment, cervical cancer patients commonly experience sexual health problems that lead to marital conflict. However, the sexual health cognition, distress and needs of patients’ spo...
Impact of persistence to secondary preventive medication on prognosis for patients with myocardial infarction with and without obstructive coronary arteries
Background Poor adherence to secondary preventive medication after myocardial infarction (MI) negatively affects long-term prognosis, but knowledge is lacking regarding the impact of poor adherence on...
Changes in individuals’ glaucoma progression velocity after IOP-lowering therapy: A systematic review
Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy often associated with increased intraocular pressure (IOP). Monitoring glaucoma progression velocity, for example, the rate...
Navigating Nepal’s health financing system: A road to universal health coverage amid epidemiological and demographic transitions
Background Nepal has been undergoing demographic and epidemiological transitions, marked by an increasing burden of non-communicable diseases (NCDs) and injuries. These transitions have led to financi...
DEFIF-Net: A lightweight dual-encoding feature interaction fusion network for medical image segmentation
Medical image segmentation plays a crucial role in computer-aided diagnosis. By segmenting pathological tissues in medical images, doctors can observe anatomical structures more clearly, thereby achie...
A tool for assessing sex/gender bias in epidemiological studies of occupational health: Pilot testing on studies of sedentary behaviour at the workplace and cardiometabolic health
Background The perspective of sex/gender bias is often missing in tools used to assess study risk of bias in systematic reviews. The aim was to pilot a checklist using an aetiological occupational hea...
Innovation of eco-friendly TiO2 nano catalyst for new pyrimidine carbonitiriles candidates, assessed for significant antioxidant activity, anti-inflammatory effects, and by insilico studies
Production of titanium dioxide nanoparticles (TiO2- NPs) is carried out in high quantities for an extensive range of applications. These nanoparticles have various physicochemical properties, which ca...
Understanding public perception of health examination services: Key factors influencing satisfaction in Türkiye
The aim of this study is to evaluate the level of satisfaction with health examination services in Türkiye. It is thought that the findings will contribute to the more effective management of the heal...
The impact of autonomy-supportive organizational environments on employees’ emotions and creative performance: A self-determination theory perspective
The ongoing debate over whether positive or negative emotions foster creative performance remains a pivotal issue in understanding the interplay between emotions and creativity. Emerging research sugg...