PLoS ONE
Articles in this Issue
Two cancer cell lines utilize Myosin 10 and the kinesin HSET differentially to maintain mitotic spindle bipolarity
Cancer cells often undergo mitosis possessing more than two centrosomes. To avoid a multipolar mitosis, the consequences of which are typically aneuploidy induced senescence, they must cluster their e...
Impute the missing data by combining retrieved dropouts and return to baseline method
Currently, various methods have been proposed to handle missing data in clinical trials. Some methods assume that the missing data are missing at random (MAR), which means that it is assumed that subj...
Optimized Grasshopper Optimisation Algorithm enabled DETR (DEtection TRansformer) model for skin disease classification
Skin disease classification is a choir cognate for early diagnosis and therapy. The novelty of this study lies in integrating the Grasshopper Optimisation Algorithm (GOA) with a DETR (DEtection TRansf...
Three-month functional outcomes of acute ischemic stroke in patients with chronic renal function impairment
Background Chronic renal function impairment (RFI) increases the risk of acute ischemic stroke (AIS), greater stroke severity, and post-stroke disability and mortality. Objective We aimed to assess...
Application and evaluation of traditional garden culture in modern urban landscape design under the context of cultural sustainability
The United Nations Educational, Scientific and Cultural Organization (UNESCO) views cultural diversity as a core driver of sustainable development. Traditional garden culture, as an essential componen...
Clarifying the meaning of a positive living environment in nursing homes: A scoping review protocol
Background Nursing homes provide permanent residence and care for older individuals who can no longer live independently. Despite efforts to create a safe and homelike environment, concerns persist re...
Adaptation and psychometric properties of Psychological Skills Inventory for Sport (PSIS-R5) in Latvian athletes: Insights and implications for practice
Background and objective Psychological skills are critical for high achievement and elite sports performance. However, there remains a lack of valid, reliable, and accessible instruments adapted to mo...
Why does formalism exist in local environmental rectification? A qualitative comparative analysis based on Central Environmental Protection Inspection cases
China’s Central Environmental Protection Inspection (CEPI) has achieved significant results, with 287,000 public reports received by June 2022, facilitating the resolution of numerous environmental is...
Comparison of the results of in-person and mobile phone surveys for a health facility assessment in Tajikistan: A validation study protocol
Health facility assessments provide important data to measure the quality of health services delivered to populations. These assessments are comprehensive, resource intensive, and periodic to inform m...
Food hygiene practices and associated factors among food handlers in food establishments of Jimma City, Southwest Ethiopia
Background Food hygiene has been a global headache due to its high impact on human health as well as its adverse effects on socioeconomic productivity. It is important to recognize the worth of food h...
Associations of flavonoid intakes with metabolic dysfunction-associated steatotic liver disease in US adults
The incidence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is rising annually. Dietary intervention is a cornerstone of MASLD management. Flavonoids, which have anti-inflammator...
The added diagnostic value of RT-PCR on faeces for the diagnosis of COVID-19
Objectives To determine whether combining a SARS-CoV-2 RT-PCR on a fecal sample [FS] with a RT-PCR on an upper respiratory tract sample [URTS] results in additional COVID-19 diagnoses. Methods We co...
Hepatotoxicity of ICI monotherapy or combination therapy in HCC: A systematic review and meta-analysis
Background The aim of this study was to reveal the hepatotoxicity profile of different immune checkpoint inhibitor (ICI) used strategies in patients with Hepatocellular carcinoma (HCC) by meta-analysi...
Protection induced in pigs previously infected by the non-virulent strain 1330 of Streptococcus suis serotype 2 is not due to the secretion of the bacteriocin suicin
Streptococcus suis is a systemic pathogen of swine and imposes a significant economic burden on the swine industry. Disease with S. suis is controlled with antibiotic treatment and vaccination with in...
Factors involved in vulvar pain during sexual activity and persistence in sexual activity amidst pain
Evidence suggests that women often endure pain during sexual activity, continue engaging in such activity despite experiencing pain, and tend to avoid communicating these painful experiences to their...
Legal education reform and medical litigation: Improved access but delayed justice in plastic surgery malpractice cases in South Korea
South Korea’s 2009 legal education reform, which replaced the bar exam and two-year judicial training system with graduate-level law schools, aimed to enhance the quality and accessibility of legal se...
Healthcare-seeking behaviour of fever cases in Magude district, southern Mozambique: A qualitative study
Fever is the main manifestation of malaria, which is a major public health concern in Mozambique. Achieving prompt diagnosis and appropriate management of all malaria cases is key to avoiding severe m...
A deep learning-based algorithm for the detection of personal protective equipment
Personal protective equipment (PPE) is critical for ensuring the safety of construction workers. However, site surveillance images from construction sites often feature multi-size and multi-scale targ...
Deliberate practice for retinopathy of prematurity: Retinal laser training using schematic eyes in ophthalmology education
Skills and confidence in performing high-risk procedures are essential for ensuring safe patient care. Deliberate practice is an instructional model designed to improve performance by engaging trainee...
TransembleNet: Enhancing vector mosquito species classification through transfer learning-based ensemble model
Mosquitoes, which belong to diverse species, play a significant role in ecological systems and public health. The accurate identification (classification) of mosquito species is essential for a compre...
Proteomic profiling of small extracellular vesicles from bovine nucleus pulposus cells
Small extracellular vesicles (small EV) are a conserved means of communication across the domains of life and lately gained more interest in mammalian non-cancerous work as non-cellular, biological th...
The awareness of chronic kidney disease in non-medical female university students: A cross-sectional in Riyadh, Saudi Arabia
Background Assessing the level of knowledge about Chronic Kidney Disease (CKD) is very crucial for society. Research on CKD knowledge can help to identify gaps in public understanding and develop targ...
A model of the impact of land use change on its carbon sequestration capacity
Different land-use types have different carbon sequestration capacities, and changes in land-use type directly cause changes in carbon sequestration capacity. To understand the change trend of carbon...
Targeted drug screening for autism based on Cav1.2 calcium ion channel
This study presents a targeted virtual drug screening approach for autism spectrum disorder (ASD), focusing on Cav1.2 calcium ion channels as potential therapeutic targets. ASD is a complex neurodevel...
Spontaneous symmetry breaking and panic escape
Panic-induced herding in individuals often leads to social disasters, resulting in people being trapped and trampled in crowd stampedes triggered by panic. We introduce a novel approach that offers fr...