PLoS ONE
Articles in this Issue
Identifying functional roles and pathways of shared mutations in canine solid tumors by whole-genome sequencing
Identifying genetic mutations contributing to solid tumors by altering the biological pathways related to tumor formation and development is essential for the development of targeted therapies. This s...
Pre-exercise health screening in the UAE: A necessity or barrier to engage in physical activity?
Background Sedentary lifestyles contribute to the rise of non-communicable diseases, making physical activity (PA) crucial for public health. Pre-exercise screening is an important tool for ensuring s...
Biocontrol of Cercospora leaf spot in sugar beet by a novel Bacillus velezensis KT27 strain: Enhanced antifungal activity and growth promotion in laboratory and field conditions
Diseases in crops are a major contributor to yield reduction and economic losses. Cercospora leaf spot (CLS), caused by Cercospora beticola, is among the most severe diseases affecting sugar beet and...
Hematological and biochemical alterations in preeclampsia: Readings from cord blood analysis
Background Preeclampsia is a serious complication of pregnancy characterized by hypertension and proteinuria that adversely affects both maternal and fetal health. This study aimed to investigate hema...
Unraveling the hidden link between asthma and depression among University students in Bangladesh
Background Asthma is a severe long-term respiratory and multidimensional disease. It affects a large proportion of people worldwide. Knowledge regarding asthma and its impact on depression among unive...
Ovalbumin-specific regulatory T cells differentiated from the naïve phenotype (CD44loCD62Lhi) in mesenteric lymph nodes stably suppress enteropathy even in severe food-allergic mice
Impaired expansion, stability, and function of regulatory T cells (Tregs) are reported in patients with severe allergy. Transfer of Tregs is a potential means of treating severe food allergy; however,...
Staff, resident, and care partner perceptions on the use of a personalized tablet to mitigate the impact of isolation in long-term care residents
Background and Objectives The Dementia Isolation Toolkit (DIT) project developed DIT-Tech, a tablet-based tool to engage residents. Implementing such technology faces challenges like digital literacy...
The maternal postnatal six-week check in women with epilepsy: Does the prevalence or subsequent postpartum health differ from the general postnatal population?
Objectives To examine the prevalence of the maternal postnatal six-week check (SWC) in women with epilepsy compared to a sample of the postnatal population without epilepsy, and assess whether the SWC...
Registered report protocol: Factors associated with inter-rater agreement in grant peer review
Grant peer review processes are pivotal in allocating substantial research funding, yet concerns about their reliability persist, primarily due to low inter-rater agreement. This study aims to examine...
Host-pathogen protein interaction studies: quality control of cDNA libraries using nanopore sequencing
Protein-protein interactions (PPI) play a key role in host-pathogens interaction studies, as proteins are essential to many cellular mechanisms. The yeast two-hybrid (Y2H) approach is a well-establish...
Correction: Face masks to prevent transmission of respiratory infections: Systematic review and meta-analysis of randomized controlled trials on face mask use
Glycaemic level and glycaemic variability in acute ischaemic stroke and functional outcome: An observational continuous glucose monitoring study
Introduction Glycaemic variability has been associated with poor outcomes in critically ill patients. We aimed to study the association between glycaemic variability and functional outcome in patients...
Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system
Evolutionarily conserved transforming growth factor β (TGF-β) signaling is used in both vertebrates and invertebrates to regulate a variety of developmental and cellular processes. The...
Implementing injury prevention strategies in community-based youth football: The role of parents, coaches, and organizational leaders
The objective of the study was to gather perspectives and experiences of parents, coaches, and organizational leaders surrounding safety in youth football as it relates to roles and responsibilities o...
Reversible neuropathic pain model created by long-term optogenetic nociceptor stimulation using light-responsive pain mice
Neuropathic pain has a significant social impact, with high morbidity and reduced productivity, the underlying mechanisms of neuropathic pain remain poorly understood, and effective therapeutic strate...
Molecular epidemiology and phylogeny of Anaplasma species in goats from Pakistan
Despite a goat population of approximately 80 million in Pakistan during 2020−2021, the prevalence of vector-borne pathogens in goats remains largely underexplored. This study aimed to assess the mole...
Undesired nexus poor health status of child under-five: A case study of Pakistan
Childhood morbidity and mortality are key indicators of human development, particularly reflecting poor health conditions in children. In Pakistan, child mortality remains a serious problem despite ef...
Optimized tacrolimus dosing strategy in kidney transplant recipients receiving nirmatrelvir-ritonavir for COVID-19
Kidney transplantation recipients (KTRs) represent a vulnerable population for COVID-19 infection and severe disease. Nirmatrelvir-ritonavir has demonstrated efficacy in treating COVID-19 among KTRs,...
Preoperative kidney tumor risk estimation with AI: From logistic regression to transformer
We consider the problem of renal mass risk classification to support doctors in adjuvant treatment decisions following nephrectomy. Recommendation of adjuvant therapy based on the mass appearance pose...
Kernel generalized least squares regression for network-structured data
In this paper, we study a class of non-parametric regression models for predicting graph signals {𝐲t} as a function of explanatory variables {𝐱t}. Recently, Kernel Graph Regression (KGR) and Gaussian...
Exploring how complex multiple-choice questions could contribute to inequity in introductory physics
Introduction: High-stakes exams significantly impact introductory physics students’ final grades and have been shown to be inequitable, often to the detriment of students identifying with groups histo...
Retrospective cohort of a decade of pediatric kidney transplant in a Brazilian state: Clinical profile, main complications, and outcomes
Pediatric kidney transplant is performed globally, although unevenly, with specific challenges in low-income countries with limited resources. We aimed to describe pediatric kidney transplantation in...
Anesthesia isn’t sleep: The neuronal dynamics of immobility in isoflurane-anesthetized C. elegans differ from the activity patterns of previously established sleep-like quiescent states
Background C. elegans possesses a precisely defined pattern of neuronal activation associated with its quiescent sleep-like state. As for higher-order creatures, this state includes the induction of a...
Towards robust medical machine olfaction: Debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles
Prostate cancer (PCa) is a major, and increasingly global, health concern with current screening and diagnostic tools’ severe limitations causing unnecessary, invasive biopsy procedures. While gas chr...
Screening for variable drug responses using human iPSC cohorts
We have developed a laboratory-based drug screening platform that uses a cohort of human induced pluripotent stem cell (hiPSC) lines, derived from different donors, to predict variable drug responses...