PLoS ONE
Articles in this Issue
A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression
Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal process that afflicts approximately 10% of preterm infants born in the United States each year, with a mortality rate of 30%. NEC se...
Spatial characteristics and determinants of traditional village distribution in Guizhou Province
This study employs a range of analytical techniques, including the geographical detector, kernel density estimation, imbalance index, geographical concentration index, and nearest neighbor index, all...
Interactive, computer-based, and situated design for innovative formative assessment approaches
Social and teamwork skills are essential for today’s teachers, yet their assessment in authentic contexts is challenging. This study presents the design, development and validation of an innovative co...
Evaluation of metatranscriptomic sequencing protocols to obtain full-length RNA virus genomes from mammalian tissues
High-throughput sequencing technologies have advanced RNA virus genomics, but recovering viral genomes from mammalian tissues remains challenging due to the predominance of host RNA. We evaluated two...
Age-related differences in trust beliefs during middle childhood: Downward-extension and validation of the general trust scale
There are conflicting suggestions concerning the developmental trend of trust beliefs during middle childhood. Across three studies, the current research developed a brief measure of child general tru...
Construction of a proximity labeling vector to identify protein-protein interactions in human stem cells
Identification of protein-protein interactions is essential for understanding protein functions in biological processes. While immunoprecipitation has traditionally been used to isolate proteins and t...
XLLC-Net: A lightweight and explainable CNN for accurate lung cancer classification using histopathological images
Lung cancer imaging plays a crucial role in early diagnosis and treatment, where machine learning and deep learning have significantly advanced the accuracy and efficiency of disease classification. T...
Habitat use and abundance of an introduced population of the Japanese weasel (Mustela itatsi): Comparison with the native population
Understanding habitat use and abundance is essential for elucidating the impact of invasive species. Invasive carnivores affect ecosystems by preying on native animals. In Japan, the Japanese weasel (...
Kaizen: Decomposing cellular images with VQ-VAE
A fundamental problem in cell and tissue biology is finding cells in microscopy images. Traditionally, this detection has been performed by segmenting the pixel intensities. However, these methods str...
Segmentation-based deep 2D-3D multibranch learning approach for effective hyperspectral image classification
Deep learning has revolutionized the classification of land cover objects in hyperspectral images (HSIs), particularly by managing the complex 3D cube structure inherent in HSI data. Despite these adv...
Correlations between pain, functioning, and quality of life in manual wheelchair users with spinal cord injury
Background Pain after spinal cord injury (SCI) is one of the most important contributors to poor rehabilitation outcomes, reduced quality of life (QOL) as well as poorer physical, social, and psycholo...
Initial coral assemblage drives benthic community response to different disturbance type events
An increase in the intensity and frequency of extreme environmental conditions due to anthropogenic climate change impacts coral reefs through myriad stressors, from elevated sea-surface temperatures...
The mediating role of technology anxiety in the impact of loneliness on technology behavioral intention among community-dwelling older adults
In this modern digital era, older adults encounter considerable challenges in technology adoption, primarily due to varying degrees of technology anxiety and its implications on their behavioral inten...
Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study
Vibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to...
Impact of functional status and biomarkers on hospital costs and readmission rates in geriatric patients: An observational study with comprehensive geriatric assessment
This study aimed to analyze the association between functional status, biomarkers, and hospitalization characteristics on costs and the probability of re-admission at 30 and 180 days in geriatric pati...
Research on anti-rollover active control of sports utility vehicle with time-delay compensation function
The global incidence of traffic accidents caused by vehicle rollovers has exhibited a persistent upward trajectory in recent years. This paper proposes a novel rollover prevention control method incor...
NMR and SEM fractal dimensions explore shale pore structure taking the Upper Paleozoic shale in Ordos Basin as an example
In this paper, the fractal dimension is calculated by extracting pore parameters from SEM images and NMR experimental data, the pore structure heterogeneity in plane and space is comprehensively discu...
Correction: ECP-IEM: Enhancing seasonal crop productivity with deep integrated models
Effect of exercise on Fibroblast Growth Factor 21 levels in healthy males and females
Fibroblast growth factor 21 (FGF21) is a metabolic regulator that may increase in circulation following exercise. This study was undertaken to determine if changes to FGF21 post-exercise are dependent...
Systematic analysis of the global, regional, and national burden of subarachnoid hemorrhage from 1990 to 2021
Subarachnoid hemorrhage (SAH) is characterized by high rates of morbidity, mortality, and disability, which imposes a heavy disease burden on society and families. Incidence, mortality, disability-adj...
Is intergenerational elasticity (IGE) a misleading measure of wealth mobility?
Intergenerational elasticity (IGE) is a widely used measure of wealth mobility, represented as the slope in an AR(1) model. While intended to capture the extent of wealth mobility between generations,...
MCF-Net: Personnel and machinery detection model for complex downhole drilling environments
Detection of personnel and machinery in the drilling environment of underground coal mines is crucial to the safe production of coal. However, the existing detection models seriously affect the accura...
Exploring the impact of mobile and migrant populations on mass drug administration coverage and effectiveness in Africa: A scoping review protocol
Background Neglected tropical diseases (NTDs) affect populations in tropical regions, particularly low- and middle-income countries with limited economic and health resources. Mass drug administration...
Identifying differences between those with suicidal ideation-with-action, compared to ideation alone, using a community representative sample
Background Few studies examine suicidal ideation in the general population and who might act on suicidal thoughts. It is important to understand ideators, the largest group on the...
SNP associations in the L-citrulline metabolic pathway and vascular aging in the Japanese population
Decreased nitric oxide (NO) production from the vascular endothelium is a major factor for vascular aging. Because vascular aging has few specific subjective symptoms, assessing the susceptibility to...