PLoS ONE
Articles in this Issue
In-silico prediction of multi‑target mechanisms of Pinellia ternata phytochemicals in lung cancer: Evidence from a graph‑attention‑guided virtual screening and multi‑scale simulations
Pinellia ternate has long been used to treat respiratory diseases, possessing potential anti-tumor activity and exhibiting multi-component, multi-target characteristics. This study prioritized lung ca...
Early fault detection in gearboxes via dynamic principal component analysis–driven multivariate statistical process control
Early detection of gearbox failure is essential due to their critical role in industrial operations. Therefore, effective condition monitoring techniques are required to identify incipient deviations...
Factors influencing N95 respirator use among healthcare workers in a TB specialized hospital, Bangladesh
Background Healthcare workers (HCWs) in public tertiary care hospitals, including chest diseases hospitals, experience a substantial tuberculosis (TB) burden, with 40−48% demonstra...
The association between life events and mental health among adults in Java, Indonesia: Investigating the moderating effects by education, asset index, and rural-urban area of residence
Life events (LE) are significant experiences (e.g., bereavement, illness, or job loss) that require psychological adjustment and may contribute to mental health disorders like depression and anxiety....
Trypanosomatid species infecting bats in the Fiocruz Atlantic Forest Biological Station, an urban forested fragment in Rio de Janeiro, Brazil
Trypanosomatids (Protozoa; Kinetoplastea) are obligate parasitic protozoans that infect a wide range of vertebrate hosts, including bats – the only volant mammals, widely distributed across the globe....
Physical and microbial root-zone factors underlying tomato wilt in long-term biofloc aquaponic systems
Biofloc aquaponics presents a sustainable approach to soilless crop production, but its long-term reliability is often compromised by root-zone disorders such as root rot and wilt. This study evaluate...
Understanding travel intention formation in government culture and tourism TikTok accounts: An integration of the SOR model and emotion appraisal theory
This study draws on the Stimulus–Organism–Response (SOR) model and emotion appraisal theory to examine how information quality and service quality of government culture and tourism TikTok accounts are...
The relationship between personal COVID-19 vaccination decisions and cattle vaccination practices: Evidence from a survey of South Dakota beef producers
Objectives Vaccination was a contentious issue during the COVID-19 pandemic, and experts warned about a possibility of a spillover effect—negative attitudes toward COVID-19 vaccine...
Abuse and coping strategies among older adults (above 60 years) in Lira district, Northern Uganda: A mixed-methods study protocol
Background There is a growing number of older adults facing a wide range of abuses by their caregivers and the public. However, there is not only limited information on the outcome...
Receipt of healthcare provider advice to quit tobacco use among Indian men
Introduction Healthcare provider (HCP) advice to quit smoking is an essential component of smoking cessation interventions. The National Family Health Survey (NFHS) is a periodic h...
Exploring factors contributing to antibiotic resistance: A cross-sectional empirical study in Bangladesh
Antibiotic resistance is a growing public health concern, particularly in low- and middle-income countries such as Bangladesh. This cross-sectional empirical study analyzed primary survey data collect...
Disease burden of asbestos-related diseases in China (1990–2023) based on GBD estimates: A call for stronger labor protection laws
Background Asbestos exposure remains a persistent occupational hazard in China, yet updated national estimates of asbestos-related diseases (ARDs) after 2019 are scarce. This study...
Knowledge, attitudes and behaviours of nurses about antibiotic use and antibiotic resistance in Oman
Background Antimicrobial resistance (AMR) is a significant global health challenge, with organizations worldwide emphasizing the importance of addressing inappropriate antibiotic u...
Embedded timing and alert device triggered by total dissolved solids (TDS) for monitoring disinfection duration in acidic electrolyzed oxidizing water
To address the absence of a reliable timing and alerting tool for acidic electrolyzed oxidizing water (AEOW) disinfection of medical instruments in the Central Sterile Supply Department (CSSD), we dev...
Phylogeography and population genetics of the white spotted eagle ray, Aetobatus laticeps Gill, 1865, in the Eastern Tropical Pacific
The Eastern Tropical Pacific (ETP) Spotted Eagle Ray, Aetobatus laticeps Gill, 1865, is an understudied species with limited information on its ecology and cons...
Post-COVID spirometric abnormalities in workers with intermittent high-altitude exposure: A cross-sectional study in Peru
Introduction Persistent pulmonary sequelae after SARS-CoV-2 infection remain a concern in workers exposed to environmental and physiological stressors such as intermittent high-alt...
Automated robotic arm system for real-time multi-parameter quality assessment of raw milk in cheese manufacturing
Ensuring the quality of raw milk is critical for consistent cheese manufacturing, yet traditional laboratory-based testing methods are slow, labor-intensive, and impractical for decentralized rural su...
A study of push and pull factors influencing employee retention in education sector in China: Using PLS-SEM and multi-group analysis
Employee retention remains a pressing issue and it reflects a key psychological decision-making outcome shaped by work-related stressors and organizational resources. Drawing on the Push-Pull framewor...
Large-scale cryptic proteome mining revealed potential phage-mediated host-pathogen genetic exchange in Mycobacterium tuberculosis
Background Due to inevitable evolution, clinical strains of Mycobacterium tuberculosis (Mtb) exhibit distinct phe...
Retraction: Comprehensive Logic Based Analyses of Toll-Like Receptor 4 Signal Transduction Pathway
Sex dictates IL-17A regulation: Inflammatory determinants in males versus a potassium-linked metabolic axis in females
Background Interleukin-17A (IL-17A) is a key Th17 cytokine involved in mucosal defense and chronic inflammation and serves as an important biomarker and therapeutic target in autoi...
Can knowledge reclassification accelerate technological innovation?
Technological knowledge evolves not only through the generation of new ideas, but also through the reinterpretation of existing ones. Reinterpretations lead to changes in the classification of knowled...
Assessing spider fear: Validity of a novel computerized behavioral avoidance test
Spider phobia is one of the most common specific phobias and can be highly detrimental to one’s quality of life. To evaluate the efficacy of treatments, reliable pre- and post-treatment assessments ar...
Facilitating the measurement and treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) and understanding caregiver burden using wearable devices in Rural Taiwan—Protocol for a dyadic feasibility pilot study
Introduction Alzheimer’s disease (AD) prevalence rises with societal ageing. In clinical care, behavioral and psychological symptoms of dementia (BPSD)—including depression, agitat...
Relationship of glycemic variability with delirium and mortality among critically ill elderly patients with sepsis: A retrospective matched cohort study
Objective The associations of glycemic variability (GV) with the occurrence of delirium and 90-day and 180-day mortality in critically ill patients with sepsis remain unclear. This...