PLoS ONE
Articles in this Issue
Conceptual qualitative system dynamics model for simulation of perceived workload, stress and performance from industrial work content
Workload and psychological stress, which industrial workers perceived as stressors, affected their performance after they were exposed to the work content. A model simulating the stress-performance of...
Associations between cognitive function and lifestyle factors in healthy Japanese middle-aged and older adults: A cross-sectional study
The objective of this study is to comprehensively investigate associations between cognitive function and lifestyle factors. We analyzed data from a cross-sectional study of Japanese adults that inclu...
FairCareNLP: An AI-driven patient review analyzer for healthcare
Objective To develop and evaluate an automatic patient review analyzer that applies advanced Natural Language Processing (NLP) and machine learning methods to improve the efficienc...
Multidimensional poverty reduction effect of climate smart agriculture practices among rural households in Siltie Zone, Central Ethiopia
This study investigates the effect of Climate-Smart Agriculture adoption on multidimensional poverty reduction in the Siltie Zone, Central Ethiopia. Despite growing attention to CSA as a pathway towar...
A lexical decision task for rapid estimation of crystalized vocabulary knowledge in Thai
A useful distinction within cognitive and brain sciences is that between fluid and crystallized ability. Although fluid ability is widely studied, crystalized ability, which draws on acquired, declara...
A 30-year analysis of urolithiasis burden in the North Africa and Middle East region: Findings from the global burden of disease study 2021
Background Urolithiasis, a prevalent urological disorder, is associated with significant morbidity and economic burden. Despite the Global Burden of Disease (GBD) data, regional sp...
Randomized controlled trial comparing AI-assisted digital and conventional orthodontics: Superior PAR reduction and occlusal outcomes
Background Advances in digital orthodontics and artificial intelligence (AI) planning have the potential to enhance treatment precision, but randomized evidence based on the Peer A...
Healthcare providers’ awareness of a mobile-based app for disease classification in northwest Ethiopia: A multilevel logistic regression analysis
Background Mobile health (mHealth) apps improve healthcare providers’ accurate disease classification in resource-limited settings. Ethiopia recently introduced the National Health...
Esports in-game consumption across generations: Integrating motivated reasoning theory and the theory of planned behavior
The revenue from virtual non-functional products has become a significant revenue source for the video game industry. Despite growing interest, understanding the decision-making processes behind virtu...
The mechanism of high-quality logistics in rural industrial upgrading—A dual moderation perspective of technological innovation and digital finance
High-quality logistics development plays a crucial role in upgrading the rural industrial structure. It aims to explore the impact mechanism and underlying logic of high-quality logistics development...
Improving tomato yield and production economics with Nano-NPK fertilization and salicylic acid chemigation
Nanotechnology-enabled NPK fertilization combined with biostimulants offers a sustainable approach to enhance crop productivity, resource-use efficiency, and environmental performance in specialty cro...
Phytase and phosphate-solubilizing Bacteria addition improves P availability and uptake by maize in low-phosphorus red soil
This study investigated the effects of phytase (PHY) and phosphate-solubilizing Bacillus (PSB) isolates on maize growth and phosphorus (P) acquisition in low-P...
Risk of Parkinson’s disease in patients with schizophrenia: Impact of antipsychotic medication use
Background/objectives Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, and its incidence is steadily increasing....
How metaverse music platform cues shape content creation behavior: Evidence from social and flow pathways
This study examines how metaverse music platform design influences users’ content creation behavior. Drawing on the Stimulus–Organism–Response framework, it develops a dual-path model in which relatio...
Interpretable miRNA-based prediction model for early detection of pancreatic cancer: Development and cross-platform validation
Background Pancreatic cancer remains one of the most lethal malignancies, largely due to delayed diagnosis. Although microRNA (miRNA) biomarkers show promise, many previous studies...
Storage and disposal practices of unused and expired medications among adult women attending Banadir Hospital, Mogadishu, Somalia: A cross-sectional study
Improper storage and disposal of unused and expired medications in households pose significant environmental and public health risks. A cross-sectional study was conducted in November 2025 among 427 c...
Editorial Note: Immuno-PCR - A New Tool for Paleomicrobiology: The Plague Paradigm
Cardiovascular risk assessment with SCORE2 and targeted health dialogues in primary care patients with mental illness
Background Patients with mental illness face a higher risk of cardiovascular disease (CVD), mainly due to unhealthy lifestyle habits. The CVD risk assessment tool Systematic COrona...
Differences in gene expression may contribute to the racial differences in the risk of MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), exhibits marked racial disparities in incidence, progression, and clinica...
Evaluation of the psychometric properties of the Episodic Disability Questionnaire (EDQ) among women living with HIV in the United Kingdom: A self-reported repeated measure study
Background Disability is increasingly experienced by women ageing with HIV and multimorbidity. The Episodic Disability Questionnaire (EDQ) measures the presence, severity, and epis...
Source-to-sink coupling and spatiotemporal evolution during multiphase rifting: The Jurassic-Cretaceous Lishu fault depression, Southeastern Songliao Basin
Source-to-sink (S2S) systems exert a fundamental control on sediment dispersal and reservoir development in multiphase rift basins; however, their coupling mechanisms and spatiotemporal evolution rema...
Screening macrophage polarization genes in spinal cord injury as therapeutic targets
Macrophage polarization correlates strongly with the progression and prognosis of spinal cord injury (SCI), yet the therapeutic potential of macrophage polarization-related genes (MPRGs) in SCI remain...
Does access to finance condition firms’ green investment responses to environmental pressure? Evidence from Vietnam
Environmental regulation is widely viewed as a key driver of firms’ green investment, yet evidence remains mixed, particularly in emerging economies where financial constraints are pervasive. This stu...
Capability–environment configurations driving exploratory innovation in art entrepreneurs: A mixed-methods configurational study
Exploratory innovation has become a critical factor for art entrepreneurs to remain competitive in dynamic environments. However, existing studies predominantly focus on high-tech or resource-rich fir...
Association of early discharge and clinical outcomes following proctectomy for patients with rectal cancer: A NRD analysis
Background Adoption of enhanced recovery pathways in proctectomy has gained attention due to its potential to reduce resource utilization and optimize recovery. Using a nationally...