PLoS ONE
Articles in this Issue
Network toxicology and bioinformatics analysis predict potential molecular targets and mechanisms by which sevoflurane and propofol influence type 2 diabetes mellitus
Background Sevoflurane and propofol are commonly used anesthetics that may exert pronounced effects on glucose metabolism and cardiovascular function in patients with type 2 diabet...
I2I - From illusion to illumination: A neoteric deep learning model for recognizing medical situation actions using depth sensors data
Among many issues, Robot vision experiences illumination challenges very frequently. Existing Human Action Recognition techniques perform excellently in state of the art, instead of scarce considerati...
The effect of tempi and mode on the rating of the perceived emotion in music
In this study, we investigated the impact of tempi variations (60, 100, 120, and 150 beats per minute) and major and minor modes on the perceived emotional content of music. To explore this, we create...
Research on strategies for enhancing the competency of safety directors in EPC projects empowered by AI
With the widespread application of the engineering–procurement–construction (EPC) delivery model in large-scale infrastructure and complex industrial projects, the highly dynamic construction environm...
State-amplified platform inequality: The economic geography of digital cultural policy in China
Digital platformization is reshaping not only markets but also the spatial organization of cultural development. While platform concentration has been widely examined in commercial sectors, its territ...
Dual pandemic of firearm injury and COVID-19 in Central and Southeastern Ohio: An interrupted time series analysis
Firearm injuries increased as the United States faced the COVID-19 pandemic, a phenomenon some refer to as the “dual pandemic.” This study examines how one regional trauma system fared during the init...
Predicting leaf traits in wine grapes with reflectance spectroscopy
Estimating crop trait data is critical for predicting crop responses to environmental change, enabling more informed diagnoses of crop performance and the development of on-farm management strategies....
KT-YOLO: A multi-convolution kernel collaboration model for dense Hu sheep behavior detection
Computer vision has been extensively applied to sheep behavior detection in recent years. However, the dense distribution of Hu sheep poses detection challenges, while imbalanced behavioral categories...
Investigating ChatGPT-mediated mind mapping to facilitate EFL learners’ reading comprehension
Mastering Reading Comprehension (RC) is a significant challenge for English as a Foreign Language (EFL) learners. This quasi-experimental mixed-methods study examined the potential effectiveness of a...
Attack and defense networks in a student social system
Signed networks are a tool that researchers use to study the relationships between individuals in a complex system. Many studies focus on negative relationships and how these shape the structure of co...
Impact of vitamin D on gene expression in Atlantic salmon skin
Vitamin D is a crucial micronutrient for vertebrate health that affects musculoskeletal function and likely modulates immune responses in tissues such as the skin. Infectious diseases are a critical c...
Experimental and numerical study on the flexural capacity of fiber mesh fabric-reinforced RC slabs
This study experimentally investigates the effects of embedded carbon and glass fiber mesh fabrics on the flexural performance of one-way reinforced concrete (RC) slabs. Five slab specimens, incorpora...
The carbon footprint of surgical operations: 2023–2025 systematic review update
Surgical care significantly contributes to greenhouse gas emissions, with operating rooms consuming three to six times more energy than other departments relying heavily on single-use materials and an...
Maintaining function and participation through tailored 24-hour movement behaviours for people living with multiple long-term conditions and frailty (The PERSONAL-AGILITY study): Protocol for a randomised controlled feasibility trial
Introduction Maintaining function and participation through tailored 24-hour movement behaviours for people living with multiple long-term conditions (MLTC) and frailty (The PERSON...
A novel hybrid framework integrating GA-driven 3D ResUNetGAN for MRI brain tumor segmentation
Accurate brain tumor segmentation by multi-modal MRI is crucial for diagnosis, treatment planning, and prognostic assessment. This work proposes a novel hybrid architecture within a GA optimized by 3D...
Sociodemographic and mental health predictors of mental health service use across provider types
Objective To examine trends in mental health service use across four provider types (family doctors, psychiatrists, psychologists, and social workers) and identify sociodemographic...
Implicit 3D geological modeling method based on expert knowledge constraints: A case study from the Songshugang Mining District, Hengfeng County, Jiangxi Province, China
Implicit 3D geological modeling offers advantages in rapid model construction; however, purely data-driven approaches have limitations in modeling accuracy and often fail to represent complex geologic...
Supported storytelling through the ‘Life Threads’ approach for family members after traumatic brain injury: “We’ve been through all of this trauma, and you’re giving me some string?”
Traumatic brain injury (TBI) brings inevitable and significant changes for family members, yet there is little to relieve their trauma, resolve their grief, or prevent ongoing suffering. The aim of th...
“We do anything to get alcohol”: A mixed methods approach to explore the intersections between alcohol use and HIV risk and infection amongst adolescent girls and young women from high HIV-burdened communities in South Africa
Despite national declines in HIV prevalence, adolescent girls and young women (AGYW) in South Africa continue to face a disproportionate burden of HIV infection. The syndemic theory provides a framewo...
Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study
Background Leptin and adiponectin link adiposity with metabolic regulation. While their fasting levels have been extensively studied, little is known about their postprandial dynam...
Defect induced improved capacitive performance of MnS incorporated MoO3 nanocomposite for supercapacitor electrodes in aqueous electrolytes
Electrode materials play a crucial role in improving supercapacitor performance. In this work, MnS nanoparticles were incorporated into MoO 3 to form a MoO...
MetaboVariation 2.0: Multivariate analysis for identifying metabolite variation at the individual level
Variations in individuals’ metabolic profiles are the result of their genetic makeup and environmental and lifestyle factors. To address the challenge of identifying these intra-individual variations...
Assessing educational poverty: Insights into youth opportunities
Educational opportunities (EO) are the main drivers for ensuring the balanced growth of future generations and a more prosperous future for the community. A lack or inadequacy of EO can lead to condit...
Diagnostic value of antibody responses to Mycobacterium avium subsp. paratuberculosis-derived proteins PtpA and PtpB in rheumatoid arthritis
Evidence suggests that Mycobacterium avium subspecies paratuberculosis (MAP) may contribute to autoimmune diseases such...
SuperSelective PCR primers for determining cis/trans configurations of mutations within the same gene
In non-small cell lung cancer, the choice of an effective targeted therapy often depends on the presence of a somatic mutation that alters an amino acid in a key protein. However, if an additional som...