PLoS ONE
Articles in this Issue
Health commodities inventory management performance and associated challenges in selected public health facilities of South Gondar Zone, Amhara Region, North Central Ethiopia: A mixed-methods cross-sectional study
Introduction In the healthcare system, the supply chain refers to the coordinated flow of physical and technical resources needed to deliver quality patient care while adhering to...
YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA
Cardiac diseases frequently arise from compromised cardiomyocyte differentiation and function. Although studies have demonstrated that loss of the m 6 A modific...
Communicating unexpected news to pregnant people living with mental health conditions in fetal medicine (the UNDERSTAND study): Healthcare professionals’ perspectives
Objectives This study explores the perspectives and experiences of healthcare professionals (HCPs) in a multidisciplinary fetal medicine (FM) team when delivering unexpected news i...
Real world experience with cyclin dependent kinase inhibitors in metastatic breast cancer in India
Background The present study evaluated the real-world experience with cyclin dependent kinase 4/6 inhibitors palbociclib and ribociclib in hormone receptor-positive/ human epiderma...
Nutritional status and associated factors among hospitalized adult patients in comprehensive specialized hospitals of Western Ethiopia
Background Malnutrition is common among hospitalized patients but is often overlooked in low- and middle-income countries like Ethiopia. Therefore, this study aims to determine its...
Serum peptidomic profiling and peptide mass fingerprinting reveal signatures associated with peroxisomal and mitochondrial pathways in MMVD-associated cardiorenal syndrome in dogs
Cardiorenal syndrome in dogs, particularly those with myxomatous mitral valve degeneration (MMVD), involves complex neurohormonal interactions, yet molecular mechanisms linking heart and kidney dysfun...
Unraveling the significance of decorin in endometriosis development through single cell sequencing and experimental approaches
Background A link exists between decorin (DCN) and endometriosis, nevertheless, the role of DCN in this condition remains unclear. This study aims to bioinformatically characterize...
The role of citizen science in mosquito-borne disease surveillance and control: A scoping review
Background Mosquito-borne diseases (MBDs) pose substantial global health and economic burdens. Although conventional MBDs surveillance systems remain essential, they are often reso...
An entropy-based framework for genomic variability analysis: A South American case study of human papillomavirus
The genetic diversity of Human Papillomavirus (HPV) poses challenges for molecular detection and genotyping, particularly in regions with distinctive circulating variants such as South America. This s...
At the roots of Plant Awareness Disparity (PAD): Semantic processing and numerosity perception
Plant Awareness Disparity (PAD) refers to the inability of humans to notice plants and recognize their importance. Among the various factors (e.g., cultural) contributing to PAD, the less prominent vi...
Prevalence and determinants of suboptimal health status among outdoor labor workers in Chengdu, Southwest China: A cross-sectional study
Background Suboptimal health status, termed sub-health, is a global public health problem. It is an intermediate health condition between health and disease. This study aimed to in...
Frontline decision autonomy under decentralization: Evidence from health sector reform
Decentralization is designed to transfer autonomy from more central to more local actors, yet studies show differences in the autonomy realized under these reforms. Drawing on the case of health secto...
Functions of Uninflatable in the Drosophila melanogaster wing and notum
The Drosophila gene uninflatable ( uif ) encodes a conserved insect protein, fir...
Design and evaluation of a resilient IBN architecture: Integrating post-quantum cryptography with adaptive threat detection using machine learning
As the domain of network security keeps on evolving rapidly, especially in sensitive areas such as healthcare systems, the demand for reliable device verification, controlling access, and spotting thr...
Analyses of eye lens stable isotopes across ontogeny of trophically diverse freshwater salmonids
Ontogenetic niche shifts in fishes are nearly universal but remain poorly understood in many species despite being fundamentally important for the persistence, management, and conservation of fish pop...
Factors that influence care for second and third trimester termination of pregnancy for medical reasons in Canada: A qualitative investigation
Background Termination of pregnancy in the 2 nd /3 rd trimester for m...
Spatiotemporal localization of sex difference in plantar pressure distribution during self paced walking in healthy Japanese adults
Objectives There is notable sex difference in the manner of locomotion, but researchers are yet to obtain the comprehensive information about the biomechanical difference in gait p...
ThermiQuant™ AquaStream: A portable instrument for quantitative colorimetric isothermal nucleic acid amplification reactions in paper and tube formats
Microfluidic paper-based analytical devices (µPADs) are an attractive format for colorimetric nucleic acid amplification tests (NAATs) because they enable low-cost, portable diagnostics in resource-li...
RF-SVR-based prediction methodology for metal tube-bending rebound: Handling non-uniformity and limited sample challenges
This paper explores a prediction algorithm for determining the rebound angle of non-uniform and small-sample tubes. To address the issues of non-uniform and small-sample data, this paper proposes an a...
Feasibility and reliability of decentralized HIV-1 viral load monitoring on self-sampled blood
Background Home-based blood self-sampling for HIV-1 viral load (VL) monitoring has the potential to alleviate pressure on healthcare systems by reducing clinic visits for people wi...
Deep learning–based region merging with adaptive threshold optimization for building segmentation in remote sensing images
Precise extraction of buildings from high-resolution remote sensing images is essential for urban analysis and land management. However, accurately extracting buildings as a region of interest (ROI) f...
Modeling treatment and temperature effects on dengue transmission at the division level in Bangladesh
Dengue fever remains a growing public health threat in Bangladesh, with urbanization, temperature variability, and limited healthcare resources exacerbating recurrent outbreaks. Although many studies...
Deep learning-based bimodal speech and facial expression recognition of miners’ unsafe emotions
Under the influence of unsafe emotions, miners’ ability to perceive risks is hindered, which can easily lead to decision-making errors and safety accidents. To recognize unsafe emotions exhibited by m...
Clinical and cardiopulmonary predictors of functional recovery and complications after transcatheter aortic valve implantation: Protocol of a prospective interventional study
Introduction Transcatheter Aortic Valve Implantation (TAVI) has emerged as a less invasive alternative to surgical aortic valve replacement, especially for high-risk patients. Whil...
A solo journey in the shadow of a double-edged pandemic: A qualitative study of women’s experience of being pregnant during the COVID-19 pandemic
The COVID-19 pandemic profoundly affected the emotional well-being of pregnant women. In Sweden, no national lockdown was implemented; instead, healthcare restrictions were imposed, most notably limit...