PLoS ONE
Articles in this Issue
Threshold-adaptive pruning with multi-key homomorphic encryption for communication-efficient secure federated learning
Under the federated learning framework, frequent parameter interactions between edge devices and servers result in communication inefficiency, while conventional encryption methods fail to resist mult...
The impact of COVID-19 on longevity trends and disparities among Native Americans and Whites in the Four Corners States
Prior research has shown suboptimal health and longevity among Native Americans in the Four Corners region of the United States, which encompasses Arizona, New Mexico, Colorado, and Utah. Our study (1...
A novel Z-number based multi-stage assessment framework for problem-based learning in practical courses
Confronting the growing disparity between standardized evaluation systems and personalized competency development in practical education, this study proposes a novel data-driven framework integrating...
Osteoprotective effects of partially defatted house cricket (Acheta domesticus) powder in spontaneously hypertensive rats
Clinical evidence suggests that essential hypertension is linked to oxidative stress and inflammatory infiltration, which can complicate osteoporosis. Edible house crickets ( Achet...
Estimating particle size and velocity from fluorescence pulses: A practical validation study of flow cytometry signals analysis
When particles cross optimal measurement regions in a flow cytometer, they generate time-resolved signals (pulses) that contain valuable information. However, this information is lost when signals are...
Techno-economic analysis of a power-to-hydrogen system in heavy industries with and without national incentives
This study analyzes how national incentive programs can play a transformative role in facilitating green hydrogen adoption across emission-intensive industrial sectors. Despite the recognized potentia...
Beyond coverage: Can vaccination reduce child mortality despite structural inequality? A global ecological analysis of routine childhood immunization (2010–2023)
Routine childhood immunization is still a critical topic to global public health, since it prevents an estimated 3.5 to 5 million deaths annually. However, its access remains uneven, especially in low...
Effects of music-based occupational therapy activities on attention executive functions in children with attention deficit and hyperactivity disorder
Background Attention Deficit/Hyperactivity Disorder (ADHD) is a multifactorial neurodevelopmental disorder characterized by cognitive, motor, sensory, emotional, and behavioral dif...
Deforestation and human proximity influence Trypanosoma cruzi infection in palm-dwelling triatomines
In the southwestern Brazilian Amazon, palm-dwelling triatomines maintain sylvatic transmission cycles of Trypanosoma cruzi , the causative agent of Chagas disea...
ROS-mediated apoptosis in colon cancer cells induced by sulfated polysaccharides from Gracilaria corticata
Background Sulfated polysaccharides (SPs) from red algae have attracted considerable interest due to their antioxidant and anticancer properties....
Association between hemoglobin glycation index and cognitive function: Evidence in the elderly
Background Cognitive impairment has been a major public health challenge. This study aims to estimate the association of hemoglobin glycation index (HGI) with cognitive function in...
Vaccine confidence and hesitancy among mothers of children under six years of age in Salvador, Brazil: The role of sociodemographic factors and health service experience
Background Vaccine hesitancy remains a pressing global health concern, particularly in early childhood, where delays or refusal to vaccinate can significantly compromise public hea...
The relationship between task value of learning English and English achievement among art majors: A moderated chain mediation model analysis
Art majors often face a distinct learning context for English as a Foreign Language (EFL) learning, characterized by structural and cognitive barriers that increase the difficulty of engaging in Engli...
An alternative strategy for balancing profit maximization and risk reduction
Portfolio diversification is a central theme in modern investment theory. We revisit the classic return–risk trade-off and propose an alternative objective...
Equity premium forecasting with reliability-screened forward-looking signals
Forecasting the equity risk premium is challenging because predictive relationships are unstable out of sample. We propose a two-stage framework that generates forward-looking signals from standard ma...
Analysis of Torquetenovirus DNA levels in NSCLC patients treated with immune checkpoint inhibitors
In recent years, Torquetenovirus (TTV) load has emerged as a potential biomarker of immune competence across various clinical contexts, albeit its significance...
Comprehensive metabolomic characterization of defense reprogramming in Castanea mollissima under Oligonychus ununguis feeding stress
Piercing-sucking arthropods such as the chestnut red mite (CRM) Oligonychus ununguis impair leaf tissues by extracting nutrients from mesophyll cells, thereby l...
Development of a multiplex fluorescent qPCR assay for the simultaneous detection of bovine viral diarrhea virus and pathogenic Escherichia coli
Neonatal calf diarrhea, primarily caused by bovine viral diarrhea virus (BVDV) and enterotoxigenic Escherichia coli K99, poses a significant threat to the cattl...
Knowledge, attitudes, and practices (KAP) regarding occupational protection among orthopedic theatre nurses using orthopedic power tools (OPTs): A cross-sectional study
Introduction The objective of this study was to explore the factors associated with the knowledge, attitudes, and practices (KAP) of orthopedic theatre nurses with regard to occupa...
A sustainable yarn tension control technique for optimizing textile dyeing efficiency and water use
The textile dyeing sector contributes significantly to excessive water and energy use and environmental pollution. Managing yarn tension during the rewinding process is a crucial challenge in textile...
LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1
Chaperone-mediated autophagy (CMA) promotes cancer cell survival by selectively removing oxidatively damaged proteins, yet its precise molecular mechanisms and role in redox adaptation remain incomple...
Backbone 3.0: An R package for extracting network backbones
The backbone package for R implements models for extracting the backbone – a sparse unweighted network containing only the most ‘important’ edges – from a weigh...
Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancer...
Enhanced nitrogen removal via simultaneous nitrification and denitrification by a newly isolated strain Enterobacter cloacae GW6 from estuarine sediment
Excessive nitrogen has been discharged into natural environments due to anthropogenic activities, leading to numerous negative impacts on natural ecosystems worldwide and becoming a global environment...
Multidimensional performance characteristics of youth academy and club soccer players
Talent identification and development (TID) in soccer is complex. While physical performance and skeletal age (as an estimate of biological maturation) are well-established in TID research, the combin...