PLoS ONE
Articles in this Issue
Practical guidelines for producing non-replicating canine adenovirus vectors
Adenovirus vectors have been used for vaccine development, gene therapy, among others, because of their ease of genetic manipulation and high efficiency in delivering and expressing genes in mammalian...
Physician estimates of the feasibility of preserving the dying for future revival
Objectives To assess US physicians’ estimates of the feasibility of preservation procedures (cryopreservation, aldehyde-based fixation) for enabling future revival, their views on...
A brief xerostomia inventory for young adults
Objective Xerostomia (dry mouth) is a common condition that negatively impacts life quality for adults of all ages. Yet, xerostomia has primarily been studied among older adults an...
Neither “lumpers” nor “splitters”: A global revision of Flabellinidae s.l. nudibranchs (Gastropoda: Heterobranchia: Nudibranchia)
Nudibranch taxonomy is a prime example of the conflict between “lumpers” and “splitters”: with rampant cryptic diversity, difficult to interpret morphological characters, plastic ecology, and variable...
Exercise-based cardiac rehabilitation and atherosclerotic plaque regression in ASCVD: Is exercise really a game-changer? A scoping review of controlled trials
Exercise-based cardiac rehabilitation (CR) has emerged as a promising strategy for promoting atherosclerotic plaque regression in patients with atherosclerotic cardiovascular disease (ASCVD). Although...
Association between serum 25-hydroxyvitamin D levels and Early Vascular Aging in young and middle-aged adults
Background Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Early vascular aging (EVA) is an independent predictor of cardiovascular ris...
Using a mixed opinion dynamics and innovation diffusion model to explore the ‘best game no one played’ phenomenon
Innovative products that receive favorable reviews but never catch on with consumers belong to a category known as the “best game no one played.” We combined an adoption threshold model with an opinio...
Deep Learning outperforms physicians in myopathy and neuropathy classification based on Needle Electromyography Signal
Needle electromyography (nEMG) is a valuable tool for diagnosing patients with neuromuscular diseases. However, it is labor-intensive and is prone to diagnostic inaccuracies stemming from human biases...
DG-LLM: Decomposition-based dynamic graph adaptation of large language models for spatiotemporal traffic forecasting
Traffic forecasting plays a critical role in the field of urban planning. Yet, existing methods struggle with modeling complicated spatiotemporal dependencies and capturing long-term patterns due to t...
Distinct endometrial protein profiles in spontaneous and stimulated cycles in women with poor ovarian response: A prospective case-crossover clinical trial
The window of implantation is a critical period for embryo implantation. Ovarian stimulation can disrupt endometrial receptivity, potentially through altered gene expression and downstream protein pro...
Experiences shaping research career intention among Black, Hispanic, and Indigenous-identifying first-year allopathic medical students in the United States: A qualitative study
Objective To examine the early experiences influencing research career intentions (RCI) among MD students from racial and ethnic backgrounds underrepresented in medicine (URiM)....
Indoor methane consistently above outdoor levels in homes with natural gas service
Background Methane leaks across the natural gas process chain, including in homes. To date, no studies have described how common it is to have elevated methane in homes served by g...
Contracting the gap: The effects of identity gaps on the psychological adaptation of Taiwanese university students
With the rapid internationalization of higher education, patterns of student mobility have moved beyond the traditional intercultural model of East-to-West migration. Mainland China has become a major...
Long-term changes in the Juvenile Sockeye Salmon Rearing Capacity of the Chignik Lakes Watershed
Freshwater ecosystems respond rapidly to perturbations in climate, geomorphology, and population abundances. For migratory species in interconnected habitat networks, local habitat conditions can cont...
Psychosocial interventions for adolescents in forced migration: A scoping review protocol
Background Adolescents account for 40% of forcibly displaced people worldwide and are often the most vulnerable to mental health challenges. Although psychosocial interventions are...
Advantages and disadvantages of self-determination support strategies for people with severe or profound intellectual and multiple disabilities: A Delphi study
Background The specific advantages and disadvantages of strategies that caregivers use to support self-determination in individuals with profound intellectual and multiple disabili...
Research on railway emergency resource scheduling strategy under multiple uncertainty coupling
To address the multiple sources of uncertainty in railway emergency resource scheduling, this study uses interval numbers to characterize uncertainty in scheduling time, models resource demand as a fu...
Shared drone route scheduling optimization
Shared passenger-carrying unmanned aerial vehicle (UAV) systems offer a promising solution for urban air mobility, yet their real-time scheduling in multi-airport environments remains challenging due...
Phage therapy for recurrent urinary tract infections: A qualitative study using the theoretical framework of acceptability
Objectives To explore the anticipated acceptability of bacteriophage therapy for recurrent urinary tract infections (rUTIs) among key stakeholders in the United Kingdom, using the...
Pharmacogenomics knowledge and implementation readiness among community pharmacists in Jordan: A national cross-sectional study
Pharmacogenomics (PGx) offers a powerful strategy to improve medication safety and efficacy, yet its integration into community pharmacy practice remains limited. While an “attitude-knowledge gap” is...
Emergency department wait time in Newfoundland and Labrador, Canada: Trends and projections of physician initial assessment 2015–2026
Background This study aims to analyze and project the trend of physician initial assessment (PIA) time in rural and urban emergency departments (ED’s) across Newfoundland and Labra...
Social norms vs socioeconomic vulnerability: Gender identity and female labor force participation in Ecuador
Despite recent advances in reducing the gender gap globally, female labor force participation is still lower compared to men’s. Discriminatory social norms, such as the one that assigns to men the rol...
The w-eCura system is a novel indicator of the need for salvage surgery after non-curable endoscopic submucosal dissection in early gastric cancer: A retrospective case-controlled study
Objective This study sought to evaluate the effectiveness of the w-eCura system in determining the necessity of salvage surgery after non-radical endoscopic submucosal dissection (...
Thiol-functionalized ZrP reinforced poly(MMA-co-MI) nanocomposites: High optical transparency and superior thermal stability for optical coatings
This study presents novel transparent and thermally stable nanocomposites based on poly(methyl methacrylate-co-N-2-methyl-4-nitrophenylmaleimide) (P(MMA-co-MI)) reinforced with thiol-functionalized zi...
A streaming, certificate-based reduction for convex hull preservation in planar point sets
Convex hull computation on large planar point sets is commonly preceded by geometric filtering to reduce input size. Motivated by invariants used in incremental convex hull maintenance, we derive a st...