PLoS ONE
Articles in this Issue
Cache-efficient and vectorized parallel dynamic programming for RNA folding
In this article, we present an efficient and concise OpenMP implementation of the Nussinov RNA folding algorithm, a well-known representative of non-serial polyadic dynamic programming (NPDP). Our goa...
Variation of fruit phenotypic traits of Cinnamomum camphora from 11 provenances in China
This study aimed to characterize the diversity and variation of fruit phenotypic traits in natural provenances of Cinnamomum camphora to facilitate the selectio...
The association between platelet-to-albumin ratio and diabetic peripheral neuropathy: A cross-sectional study in the Chinese population
Introduction The early prevention and diagnosis of diabetic complications are challenging, particularly for diabetic peripheral neuropathy (DPN), which progresses insidiously and i...
Spinal mechanisms and feasibility of Dry Needling versus Botulinum Toxin Type A in post-stroke lower limb spasticity: A proof-of-concept randomized clinical trial protocol (STROKE-POC)
Introduction Stroke often causes spasticity, impacting mobility and quality of life. Botulinum Toxin type A (BTX-A) and Dry Needling (DN) are treatments that reduce spasticity, alt...
Computational models for the classification of antibody specificity using heavy chain features
Background Antibodies play a critical role in immune defense, with their antigen specificity primarily governed by the unique sequences of their heavy chains, rendering them invalu...
Social connectedness and healthcare engagement among adults with disabilities: The role of living arrangement
People with disabilities face significant healthcare engagement barriers, leading to increased risks of preventable conditions and mortality. This is particularly concerning for the quarter who live a...
Linguistic complexity of EFL writing with different levels of English proficiency: A stratified study of an application-oriented university
English writing competence is a significant manifestation of students’ second language proficiency. However, comprehensive synchronic empirical research remains scarce regarding how students at applic...
Sound-evoked pupil dilation quantifies misophonic symptoms
Misophonia is a debilitating disorder where seemingly innocuous sounds (often human made, such as chewing or throat clearing) evoke intense negative cognitive, emotional and physical “fight-or-flight”...
Digital motivation for cervical cancer screening: A quasi-experimental trial of the SeDAR Video among middle adulthood Malaysian women
Background Cervical cancer screening (CCS) is a well-established method for preventing cervical cancer (CC). Electronic health (e-health) interventions have shown potential in diss...
Advancing inclusion in sports for students with disability: A mixed-methods study on awareness and perspectives toward adaptive sports
Adaptive sports promote inclusion, participation, and well-being in individuals with disabilities. However, limited research has examined the knowledge, awareness, and perceptions of adaptive sports,...
Maximum likelihood estimation of perceptual differences in sorting tasks
Psychophysical paradigms are foundational for quantifying perceptual discrimination. Yet, a persistent trade-off between assessment efficiency and accuracy limits their broad applicability. To address...
Age differences in the conceptualization and experience of curiosity: A qualitative study
Despite the recent resurgence in research on human curiosity and its influence on knowledge acquisition, there is little consensus on how to operationalize curiosity. Understanding lay beliefs on what...
Editorial Note: A scalable blockchain-enabled federated learning architecture for edge computing
Birth in shelters: Midwives’ lived experiences in providing childbirth care amidst war in Gaza
Background The warfare against the Gaza Strip in the occupied Palestinian territory, starting in October 2023, caused massive destruction of infrastructure, including homes and hos...
Cows visually discriminate and cross-modally recognise familiar and unfamiliar human faces in videos
Social recognition has been studied and demonstrated in many species. In domesticated species, the long evolutionary history shared with humans has led to investigations into their cognitive abilities...
Relationship between physical activity and ankle osteoarthritis: Implications for metabolic diseases
Background Regular physical activity is associated with lower cardiometabolic risk, yet musculoskeletal disorders such as ankle osteoarthritis (OA) may limit activity. This study i...
Impact of a culinary medicine intervention on diet and health metrics in patients with type 2 diabetes and elevated body mass index
Purpose Culinary Medicine (CM), an educational approach blending the art of cooking with the science of medicine, has shown promise in improving diet and health outcomes. We conduc...
Cornea biomechanics and biometric evaluations in immunoglobulin G4-related ophthalmic disease
Purpose To evaluate the corneal biomechanical and biometric properties in immunoglobulin G4-related ophthalmic disease (IgG4-ROD) patients....
The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial
Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high l...
Quality of pharmacy services and adherence to good pharmacy practice at points of sale in Punjab, Pakistan: A cross-sectional study
Adhering to good pharmacy practice (GPP) guidelines ensures the safe, effective, and ethical delivery of pharmaceutical services at community pharmacies, commonly referred to as Point of Sale (POS). H...
Challenges to human papillomavirus vaccination among young girls in Morocco: A national cross-sectional study
Background The human papillomavirus (HPV) vaccine helps significantly reduce the incidence of cervical cancer. However, in many countries, its adoption remains limited. In this con...
Correction: Intracellular cGMP increase is not involved in thyroid cancer cell death
Correction: Triethylamine inhibits influenza A virus infection and growth via mechanisms independent of viral neuraminidase and RNA-dependent RNA polymerase
Correction: Name use by companion parrots
Effect of an herbal supplement on quality of life in participants with insomnia: A randomized placebo controlled cross-over pilot trial
Background Insomnia is a common sleep disorder linked to poor quality of life. Patients with insomnia frequently rely on herbal supplements to improve sleep and quality of life; ho...