PLoS ONE
Articles in this Issue
Linear programming-based stabilization and synchronization of positive complex networks with dynamic link subsystems
This paper investigates the stabilization and synchronization of positive complex networks with dynamic links. A class of positive complex networks is constructed by introducing dynamic link between n...
Synergistic effect of westerly circulation and western North Pacific anticyclone on interannual variation of mid-spring rainfall in southeastern China
The spring rainfall in southeastern China (SEC) is a unique climatic phenomenon and has important impacts on local socio-economics. In this study, the climatological characteristics of the SEC mid-spr...
Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy
Fc fusion proteins, formed by fusing an active protein to the Fc region of immunoglobulin G, are a validated strategy for extending the half-life of therapeutic proteins. Human growth hormone (hGH) Fc...
Timing of eye removal influences low-vision quality of life and self-perception of facial appearance in people with one eye
Purpose The loss of one eye early compared to late in life coincides with critical periods of postnatal visual development and is associated with sensory adaptations which may lead to different psycho...
Research on the mechanical properties of hybrid Steel Fiber-Reinforced Self-Compacting Concrete based on the DIC method
To investigate the influence of hybrid steel fibers on the mechanical properties of self-compacting concrete, this study systematically compared the mechanical performance of ordinary self-compacting...
A combined risk model shows viability for personalized breast cancer risk assessment in the Indonesian population: A case/control study
Breast cancer remains a significant concern worldwide, with a rising incidence in Indonesia. This study aims to evaluate the applicability of risk-based screening approaches in the Indonesian demograp...
A comparative analysis of large language models versus traditional information extraction methods for real-world evidence of patient symptomatology in acute and post-acute sequelae of SARS-CoV-2
Background Patient symptoms, crucial for disease progression and diagnosis, are often captured in unstructured clinical notes. Large language models (LLMs) offer potential advantages in extracting pat...
Performance improvement of an HVAC system using water and ethylene glycol-based ternary hybrid nanofluids with green-synthesized Fe-Cu-Fe2O3 nanoparticles
This study investigates the potential of water and ethylene glycol-based ternary nanofluids, enhanced with both chemically and green synthesized Fe-Cu-Fe2O3 nanoparticles, to improve the performance o...
Network pharmacology and experimental validation to investigate the mechanism of action of Zhilong Huoxue Tongyu capsule in the prevention and treatment of diabetic cardiomyopathy
Background Diabetes cardiomyopathy (DCM) is a prevalent complication of diabetes, characterized by a multifaceted pathogenesis. Zhilong Huoxue Tongyu Capsule (ZL), a traditional Chinese medicine, is e...
Apple varieties, diseases, and distinguishing between fresh and rotten through deep learning approaches
Apples are one of the most productive fruits in the world, in addition to their nutritional and health advantages for humans. Even with the continuous development of AI in agriculture in general and a...
Disparities in physician compensation for breast and prostate cancer operations
The objective of this study was to determine whether the Center for Medicare and Medicaid services (CMS) pays more relative value units (RVUs) for prostatectomies than mastectomies across different tr...
Comparison of visual performance between monofocal and rotationally asymmetric refractive intraocular lenses
We compared the visual performance of a monofocal intraocular lens (IOL) (ZCB00) and a rotationally asymmetric refractive IOL with +1.5 diopters near addition (Lentis Comfort LS-313 MF15) by investiga...
Trajectories of illness perceptions in patients with kidney disease receiving dialysis: Relationship with psychological and physical symptoms
Illness perceptions play an important role in outcomes for patients with advanced kidney failure receiving dialysis, though they are rarely examined over a sustained period and in distinct cultural se...
Research on coupling risk assessment method of industrialized urban area based on information diffusion and extension grey clustering model
The regional accident risk in industrialized towns is a critical foundation for optimizing urban industrial layouts and dynamically managing regional risks. However, assessing production safety risks...
Combining meta reinforcement learning with neural plasticity mechanisms for improved AI performance
This research explores the potential of combining Meta Reinforcement Learning (MRL) with Spike-Timing-Dependent Plasticity (STDP) to enhance the performance and adaptability of AI agents in Atari game...
Incidence of intensive care unit acquired weakness in critically ill patients treated with kidney replacement therapy: A systematic review and meta-analysis
Background This study assesses the incidence of ICU-acquired weakness (ICUAW) among patients using kidney replacement therapy (KRT) and explores the uncertain relationship between KRT and ICUAW in cri...
Correction: Sustainable visions: Unsupervised machine learning insights on global development goals
Effects of Periodization Core Training on Physical Fitness in College Table Tennis Players
Objective This study aimed to analyze the effects of 12-week periodized core training on the physical fitness of college table tennis players. Methods A randomized controlled experimental design was...
Health care professionals intention to use digital health data hub working in East Gojjam Hospitals, Northwest Ethiopia: Technology acceptance modeling
Background Digital health data hubs contribute significantly to finding the right solutions to health problems, which forms the basis for achieving sustainable development goals. However, in Ethiopia,...
RNA degradation patterns in cardiac tissues kept at different time intervals and temperatures before RNA sequencing
Vast repositories of tissues are available in biobanks worldwide. For these tissues to be used for molecular investigations, such as gene expression analysis, it is important to understand the limitat...
Nonlinear association between C-reactive protein and severity of diabetic foot infection in patients with diabetes: A retrospective cohort study with clinical implications
Objective Diabetic foot infection(DFI) is a frequent complication of diabetes and can lead to significant morbidity and mortality. These are huge economic health burdens for patients, countries, and t...
Characterization of the complete mitochondrial genomes of two sea cucumbers, Deima validum and Oneirophanta mutabilis (Holothuroidea, Synallactida, Deimatidae): Insight into deep-sea adaptive evolution of Deimatidae
The deep-sea is the largest and most extensive ecosystem on our planet with limited food availability, extreme pressure reaching hundreds of bars, perpetual darkness, frigid temperatures, and minimal...
Korean medicine registry for cognitive disorder: A protocol for prospective observational multi-center study
Objective Despite the rapid increase in dementia and cognitive impairment incidence in Korea, research on integrative treatment for cognitive impairment using Korean medicine (KM) is still in its infa...
Comparison of different auxiliary techniques used during root canal filling removal in terms of the amount of apically extruded debris: In vitro study
Background One of the main challenges in endodontic retreatment is managing apical debris extrusion, which can influence both healing and patient comfort. Different retreatment methods result in varyi...
Association of sarcopenia with generalized anxiety disorder in Korean middle-aged and older adults: Results from the Korea National Health and Nutrition Examination Survey in 2022
We highlighted sarcopenia’s association with psychiatric disorders, including generalized anxiety disorder (GAD), and aimed to explore correlations between the detection and prevention of GAD using po...