PLoS ONE
Articles in this Issue
Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement
As the number of patients undergoing total joint replacement (TJR) surgery increases, so does the number of revision surgeries. One driver of implant failure and subsequent revision surgery is peri-im...
SOX7: Autism associated gene identified by analysis of multi-Omics data
Genome-wide association studies and next generation sequencing data analyses based on DNA information have identified thousands of mutations associated with autism spectrum disorder (ASD). However, mo...
Careful design of Large Language Model pipelines enables expert-level retrieval of evidence-based information from syntheses and databases
Wise use of evidence to support efficient conservation action is key to tackling biodiversity loss with limited time and resources. Evidence syntheses provide key recommendations for conservation deci...
Analysis of safety risks in mixed driving of manual and automatic vehicles: multiple perspectives
To improve traffic safety in mixed traffic involving human-driven and autonomous vehicles, this study explored safety risk factors from multiple perspectives. Based on crash reports involving autonomo...
Valorization of broccoli by-products: seasonal variations in bioactive compounds and their biostimulant effects on pak choi germination
The use of plant-based biostimulants is a sustainable strategy to enhance crop growth while mitigating the environmental impact of synthetic agrochemicals. Broccoli by-products, rich in bioactive comp...
Clinicohematological and molecular analysis of hemoglobin D syndrome and unknown variants in the hemoglobinopathy spectrum of Sindh, Pakistan
Objectives Hemoglobinopathies are prevalent monogenic disorders resulting from genetic abnormalities in globin genes, significantly impacting health. β-thalassemia is particularly common in Pakistan,...
Application of allogeneic adult mesenchymal stem cells in the treatment of venous ulcers: A phase I/II randomized controlled trial protocol
Objective To evaluate the feasibility, safety and efficacy of the cutaneous application of Bioengineered Artificial Mesenchymal Sheet (BAMS) in venous leg ulcers (VLUs) versus conventional treatment....
An updated comparison of standard and novel FEV1 indices’ association with all-cause mortality
Rationale Current recommendations for defining FEV1 abnormalities are based on Z-score cutoffs. Alternative approaches may better correlate with patient-related outcomes, including mortality. Object...
Research protocol of a multifaceted, comparative mixed-method study: Young people transitioning from out-of-home care in Norway and Australia - Interrelationships between policies, pathways, and outcomes
Introduction Young people who have been in the care of child welfare systems face myriad challenges as they transition into adulthood, resulting in poor long-term outcomes. The overwhelming internatio...
Association of the cardiometabolic index with sarcopenia among U.S. adults: NHANES 2011–2018 findings
Background The cardiometabolic index (CMI), initially devised as a diagnostic tool for diabetes mellitus, has evolved into a composite biomarker for evaluating metabolic syndrome and cardiovascular di...
Maternal and infant health during the COVID-19 pandemic – A Pennsylvania Study Protocol
Background Pregnant people are vulnerable to more severe outcomes of COVID-19 compared with their non-pregnant counterparts. Research is needed to systematically test the degree to which COVID-19 duri...
Genome-based reclassification of the family Stappiaceae and assessment of environmental forcing with the report of two novel taxa, Flexibacterium corallicola gen. nov., sp. nov., and Nesiotobacter zosterae sp. nov., isolated from coral and seagrass
Two novel strains, MaLMAid0302T and SPO723T, isolated from coral and eelgrass, respectively, were distinguished from other Stappiaceae species based on phenotypic, biochemical, phylogenetic, and chemo...
Prevalence and determinants of Soil-Transmitted Helminths among urban vegetable farmers in Ghana
Introduction Urban vegetable farmers in Ghana face multiple health risks, including soil-transmitted helminths (STHs), which may contribute to morbidities that threaten urban food security. Additional...
Effects of an interprofessional care concept in nursing homes evaluated in the SaarPHIR project: A cluster-randomized controlled trial
Introduction Deficits in interprofessional collaboration can lead to insufficient medical care for nursing home residents, particularly inappropriate hospitalizations. Transfers are stressful for resi...
Greenfield investments projects in manufacturing and electricity: A network analysis.
Aim of the paper Greenfield is, by definition, foreign direct investment that creates new production facilities in the host countries, which imply an addition of fresh foreign capital. This paper brin...
Analysis of web tracking and geolocation of German-language health websites
Nowadays, websites with health-related content are an essential source of information for consumers to find out about their diagnoses, therapies, but also about prevention aspects. The data protection...
Assessing newborn scoring with each resuscitation (ANSWER): Protocol for identifying and testing an Apgar score for the 21st century
Background The status of infants in the minutes after birth has been summarized by the Apgar score for the last 70 years and is applied at most medically attended deliveries around the world. It has n...
Association between lipid accumulation product and endometriosis: A cross-sectional study from NHANES 1999–2006
The association of lipid accumulation product (LAP) and the likelihood of endometriosis prevalence has not been previously mentioned. The research aimed to assess the possible potential association be...
Influence of sinker timing on loop shape, width and areal density of weft-knitted cotton plain jersey fabric
This study aims to explore the influence of sinker timing—a relative positional setting of two primary knitting elements, i.e., needle and sinker, on some important knitted fabric parameters and relat...
Socioecological benefits of academic greenspace for human health, plant, and pollinator diversity: A mixed-method study protocol
Introduction Significant risks to the health of humans and ecosystems are posed by environmental pollution, urban warming, and fragmentation, which are primary urban factors that c...
Integrating multimodal imaging and peritumoral features for enhanced prostate cancer diagnosis: A machine learning approach
Background Prostate cancer is a common malignancy in men, and accurately distinguishing between benign and malignant nodules at an early stage is crucial for optimizing treatment. Multimodal imaging (...
Navigational health literacy and health service use among higher education students in Alentejo, Portugal - A cross-sectional study
Introduction The navigational health literacy of higher education students is fundamental to effective health management and successful health navigation, thereby improving health outcomes and overall...
Investigating the Key Trends in Applying Artificial Intelligence to Health Technologies: A Scoping Review
Background The use of Artificial Intelligence (AI) is exponentially rising in the healthcare sector. This change influences various domains of early identification, diagnosis, and treatment of disease...
An unexpected diversity of powdery mildew species infecting the Fabaceae in Australia
The Fabaceae family has been reported to host more than fifty species of powdery mildew worldwide. Despite being commonly found on fabaceous hosts throughout Australia, the accurate identification of...
Customizing egg incubators for Cameroon: A design and construction guide
In Cameroon, poultry farming represents an important source of income for many families and is a key sector for economic development and food security. However, there is a deficiency in suitable infra...