PLoS ONE
Articles in this Issue
In-silico identification of anti-cholera phytochemicals from Indian medicinal plants
Cholera is a severe diarrheal disease caused by ingestion of food or water contaminated with pathogenic Vibrio cholerae . Treatment for cholera includes rehydra...
National data meets AI: Machine learning for predicting overweight/obesity among ever-married Bangladeshi women
Overweight/obesity has become a critical global health issue, as these conditions are strongly associated with elevated risk of diabetes, stroke, cardiovascular disorders, and certain types of cancer....
Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions
The LIM domain protein LIMD1 is a critical regulator of the Hippo signaling pathway, acting to sequester the kinases LATS1/2 to adherens junctions (AJs) in response to mechanical strain. Here, we iden...
Dynamic metabolic modeling of Streptomyces clavuligerus in complex medium highlights nutrient-dependent metabolic transitions associated with clavulanic acid biosynthesis
Background Streptomyces clavuligerus is the main industrial producer of clavulanic acid (CA), a potent β-lactamase inhibitor. However,...
Community voices: Exploring beliefs, attitudes, practices and recommendations for improving stroke prevention and stroke care in rural and urban communities in Nigeria
Introduction Globally, stroke is a leading cause of mortality with higher incidence in low- and middle-income countries. However, stroke beliefs and knowledge among community partn...
Correction: Genetic, clinical, lifestyle and sociodemographic risk factors for head and neck cancer: A UK Biobank study
The cost and cost drivers of delivering COVID-19 vaccines in low- and middle-income countries: a bottom-up costing study of rollouts in seven countries
Introduction While COVID-19 vaccines were crucial in containing the pandemic, there is limited evidence on the cost of delivering them in low- and middle-income countries. We estim...
Assessing research productivity in addiction datasets using OpenAlex
The Open Science model has fostered new communication and archiving processes, supported by information technology. Within this framework, the open deposit of health-related datasets and their use in...
Relationship between lactate-to-albumin ratio and all-cause mortality among critically ill pediatric patients: Results from the pediatric intensive care database
Background The lactate-to-albumin ratio (LAR) has emerged as a valuable prognostic marker in adult critically ill patients. However, evidence regarding its association with mortali...
Association between carbohydrate quality and glycemic control in individuals with type 1 diabetes: A cross-sectional and meal-based analysis
The aim of the study was to investigate the association between the quality of carbohydrates in the diet and glycemic control in individuals with Type 1 Diabetes (T1D). In this cross-sectional study,...
Leveraging videos and community health workers to address social determinants of health in immigrants (LINK-IT): Protocol for a randomized controlled trial
Background Chinese immigrants face numerous social determinants of health (SDOH) challenges that limit access to evidence-based diabetes self-management education and support progr...
Psychosocial and occupational predictors of health among Spanish University Employees: The role of job type, contract status, and seniority
The digital transformation of work environments, particularly in academia, has introduced new psychosocial risks, including technostress. This cross-sectional study analyses the relationship between t...
Assessing the accuracy and educational value of YouTube videos on a novel regional anesthesia technique (PENG block)
The Pericapsular Nerve Group (PENG) block is a novel regional anesthesia technique that provides adequate analgesia while preserving motor function. This cross-sectional study evaluated the quality, r...
Discovery of a novel Keap1 inhibitor for neurodegeneration through virtual screening and molecular dynamics simulations
Oxidative stress is a key feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor erythroid 2–related factor 2 (Nrf2)...
Professionalism and associated factors among health professions education students: A primary mixed-methods study from Qatar
Background Professionalism, the judicious use of communication, knowledge, and values for benefits of individuals and communities, is a keystone in health education, and is demarca...
Clinical and metabolic profile of adults with obesity attending lifestyle medicine clinics
Background Lifestyle Medicine Clinics (LMCs) in primary care provide structured, multidisciplinary obesity care, but evidence from Saudi Arabia on patient profiles and the effectiv...
Moderation analysis of subjective well-being, self-efficacy, and academic performance of 4th grade children in Russia
Research evidence exists on associations of subjective well-being, self-efficacy and various academic and non-academic outcomes with older students; however, there is a research gap on how these varia...
Human-anchored longitudinal comparison of generative AI with a bias-calibrated LLM-as-judge
Service LLMs evolve without public changelogs, complicating reproducible evaluation. We present a preregistered human-anchored longitudinal study that tracks three major model families over ten weekly...
Multiple sources of volunteered geographic information strengthen holistic estimates of lake visitation
Lakes provide human societies with a wide range of cultural ecosystem services (CES), yet these benefits are rarely quantified. Site visitation is frequently used to assign CES values to recreational...
Spatial overlap of sea ice-associated predators and prey in western Hudson Bay
Spatio-temporal distribution of species shapes community structure and ecosystem function, yet the mechanisms driving biological hotspots remain unclear in dynamic environments like sea ice. We comput...
Comparison of the triglyceride-glucose index and triglyceride-glucose-body mass index for predicting non-alcoholic fatty liver disease in elderly diabetic patients
Background Non-alcoholic fatty liver disease (NAFLD) is posing a challenge to global health systems. Developing an effective, simple, noninvasive method to identify NAFLD in elderl...
Feasibility of Baseline cardIac investiGation in awake elepHants (Elephas mAximus) using tRansThoracic echocardiography: The BIG HEART study
Introduction Cardiovascular diseases are common in elephants, but most cases are diagnosed only postmortem. Transthoracic echocardiography (TTE) is widely us...
Undergraduate GPA does not predict success in PhD programs for cohorts of MS students at two minority-serving institutions
Master of Science (MS) research training programs funded by organizations such as the NIH, the NSF as well as private corporations represent the potential for significant interventions for student suc...
Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway
Background Insulin resistance (IR) is commonly observed in patients with polycystic ovary syndrome (PCOS), affecting 44% to 70% of these individuals. Kisspeptin is a key regulatory...
Morphogenetic development of trochlear groove and thigh muscles from embryo to fetus in humans
Mechanical forces caused by fetal movements are essential for normal musculoskeletal development. However, the relationship between skeletal development and knee joint motion in utero remains unclear....