PLoS ONE
Articles in this Issue
Recovery-induced tipping in Stommel’s kicked ocean box model
Ocean circulation, a key driver of global climate, is subject to recurrent disturbances including freshwater input from glacial melt. Stommel’s idealized two-box model predicts two distinct stable reg...
Assessing the validity of post-discharge readmission and mortality as a composite outcome among newborns in Uganda
Background Composite outcomes, which include mortality and readmission rates, are often used in risk prediction models following hospital discharge when event rates for the primary...
The key technologies of a computer-aided design system for removable partial denture frameworks
This paper presents a computer-aided design (CAD) system for removable partial denture (RPD) frameworks, addressing the challenges of dentition defects. The system takes a digitized dental model obtai...
Genomic characterization and prognostic significance of copy number alterations in Tunisian patients with acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a heterogeneous malignancy characterized by various genomic alterations playing a crucial role in disease classification, prognosis, and response to treatment. Ho...
The effect of time–space compression in the Yangtze River Delta region under transportation integration: An accessibility-based analysis
The Yangtze River Delta (YRD) region is one of the areas in China with the highest level of transportation integration, featuring a well-developed high-speed rail network, multimodal transport system,...
Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis/chronic fatigue syndrome or control serum
Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome is a disease of uncertain aetiology that affects up to 400,000 individuals in the UK. Exposure of cultured cells to the sera of people with ME...
Fluoxetine minimally affects hearing loss but induces gene expression changes in the cochlear nuclei after noise exposure
Purpose This study investigated the effects of fluoxetine on noise-induced injuries to the cochlea and auditory nerve, with a focus on its impact on perineuronal nets (PNNs) and ge...
Psychosocial correlates of adherence self-efficacy and HIV viral suppression among adolescents and young adults in Western Kenya
Objective To measure adherence self-efficacy (ASE) to antiretroviral therapies (ART) and evaluate the relationship between ASE, depression, perceived social support, and HIV viral...
Performance evaluation of GPU-based parallel sorting algorithms
Sorting can be approached in two main ways: sequentially and in parallel. In sequential sorting, data is processed in a single-threaded manner, which can be slow for large datasets. However, parallel...
Augmented reality in engineering education: Strategic design and evidence-based results
The primary objective of this study is to define and empirically validate a novel procedural methodological framework, named SEBAS (Selection, Establishment, Blueprint, Application, Synthesis), for th...
Deep learning framework for RNA 5hmC prediction using RNA language model embeddings
By influencing gene expression and contributing to epigenetic modifications, Ribonucleic Acid (RNA) 5-Hydroxymethylcytosine (5hmC) modification significantly affects cellular pathways. It plays an imp...
Utility of inhaled β2-agonists in reducing serum potassium levels in adult patients with hyperkalemia: A scoping review
Introduction Hyperkalemia is a potentially life-threatening condition that requires prompt intervention to prevent cardiac complications. While insulin and glucose administration r...
Reselling or agency selling? Sales mode selection for a manufacturer in private label competition under information asymmetry
Big data systems enhance retailers’ predictive capabilities, providing them with a significant advantage in understanding end-market demand, increasing the competitiveness of retailers’ private labels...
Remote electrophysiological cardiotocography (eCTG), evaluation of feasibility in complicated pregnancies from 32 until 37 weeks gestational age in a home@hospital setting (HASTA): A prospective cohort study protocol
Introduction High-risk pregnancies, including those complicated by pre-eclampsia, fetal growth restriction or preterm pre-labor rupture of membranes, often require hospitalization...
Study on the influencing factors of shear strength of loess mudstone interface
In Loess Plateau, low shear strength of the loess–mudstone contact interface leads to the loess–mudstone landslides. However, the influencing factors of shear strength of loess-mudstone interface and...
Differences in the fitness effects of traded resources shape traits and persistence in multi-mutualist communities
Mutualistic interactions, where species reciprocally benefit from each other, are crucial for ecosystem stability and biodiversity. These interactions often involve species that experience different f...
Identifying chemicals associated with irritable bowel syndrome by integrating a transcriptome-wide association study with chemical-gene-interaction analysis
Background Irritable bowel syndrome (IBS) is a prominent functional gastrointestinal disorder, yet the precise causes and mechanisms behind it remain largely unclear. Numerous envi...
Informal institutions and corporate carbon emissions: Evidence from China’s listed companies
This research explores the connection between religious culture and carbon emissions through the lens of informal institutions, offering valuable insights into the shift to a green economy in China. T...
Data-driven derivation of macroscopisc fundamental diagram from floating car trajectories
This study proposes a novel GPS-based methodology for Macroscopic Fundamental Diagram (MFD) estimation to overcome limitations of fixed detectors and inaccurate penetration rate assumptions. The appro...
Multilevel factors influencing colorectal cancer screening adherence: A systematic literature review
Introduction Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Although early detection through screening significantly redu...
Scoping review protocol to investigate the experience of intimate partner violence among Black women and children living in the United Kingdom and how domestic violence specialist organisations support them to thrive
Background This protocol focuses on male-perpetrated intimate partner violence and aims to explore how Black women and children are supported to thrive post-...
Novel height estimation formula that accounts for the effects of aging based on lumbar length measurements in postmortem CT images
In forensic practice, personal identification using expert testimony is important in unidentified cases, and the height of the deceased is indispensable in identification. Although many height estimat...
Body-worn cameras to prevent workplace aggression among ticket inspectors: Protocol for a randomized controlled trial
Background Service and frontline personnel are among the occupational groups with the highest rates of workplace aggression. To address the risk of victimization, various preventiv...
How basic public health services shape social integration: Evidence from domestic migrants in China
The demand for and awareness of utilizing resident health services are increasing, yet uneven development across regions has led to uneven population mobility. Against this backdrop, as a crucial safe...
Design and performance analysis of a simplified hybrid modulation method for dual active bridge powering inverters
This paper presents a simplified hybrid modulation method for operating dual-active-bridge (DAB) converters that power inverters by integrating single-phase shift (SPS) and triple-phase shift (TPS) mo...