PLoS ONE
Articles in this Issue
SDXL model-based optimization for interior design: Data-driven and deep learning methods
This study proposes a novel, domain-specific optimization framework for the Stable Diffusion XL (SDXL) model, addressing the critical challenges of structural consistency and aesthetic fidelity in AI-...
Associations between big five personality traits, facets, and sexual fantasies
The present study investigated associations between Big Five personality traits, their facets, and the frequency and variety of sexual fantasies in a sample of 5,225 adults ( M...
SylvCiT - An AI-based support to urban forest resilience
Urban trees are attracting increasing interest due to their contribution to mitigating some negative urbanization effects. Indeed, trees provide numerous ecosystem services such as carbon sequestratio...
Investigating the effect of augmented reality-based virtual patient training on occupational therapy students’ clinical decision-making: A quasi-experimental study
Technology-enhanced education is an essential element of modern universities, improving clinical decision-making, and student performance. This study aimed to design and evaluate an augmented reality-...
Genome-wide association study revealed genomic regions associated with tuber quality traits in water yam (Dioscorea alata L.)
Water yam ( Dioscorea alata L.) or greater yam, is an essential species of the Dioscoreceae family in tropical and subtropical regions. The wide geographical di...
Design and analysis of behavioral intervention studies: A Bayesian approach
To study the effect of a behavioral intervention, it should be compared to a control or an existing treatment in an intervention study. There exist many guidelines in the literature about the design a...
Exploring the utility of dynamic motor control to assess recovery following pediatric traumatic brain injury: A pilot study
Pediatric traumatic brain injury often leads to long-term disability. Unfortunately, while currently used standard clinical measures can effectively capture secondary functional impairments, they do n...
Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1
Biliary atresia is a neonatal cholangiopathy characterized by loss of the extrahepatic bile duct causing bile acid accumulation in the liver and subsequent fibro inflammation and abnormal proliferatio...
Combined glycerol and sodium bicarbonate elicits improvements in fluid retention and blood buffering capacity
Introduction Background: It is unclear whether hyperhydration induced via glycerol, sodium bicarbonate or a combination of the two is m...
Survey of vulnerable Amazonian manatees using environmental DNA (eDNA): A method for survey in remote field settings
The only exclusively freshwater lineage of Sirenia, the Amazonian manatee (Trichechus inunguis ) is listed by the IUCN as vulnerable, with populations projected...
Toward mass customization of animal trackers by design automation
Animal-borne tracking devices (bio-loggers) are established instruments for researching animal behaviour. However, commercial animal trackers are rather standardized and not perfectly adapted to speci...
Current strategies for improving osseointegration of mesoporous silica drug delivery systems: A scoping review protocol
Mesoporous silica (MS) is widely recognized as a local drug delivery system in bone-related diseases. Although MS enables controlled or sustained release and improved bioavailability of therapeutic ag...
Probabilistic reliability assessment of reservoir-area colluvial landslides considering rotated spatial variability of geotechnical parameters
Slope reliability analysis often assumes isotropic or anisotropic random fields with horizontal orientation to characterize the spatial variability of soil parameters. However, this neglects the influ...
Lessons learnt about implementing LEGO based therapy (Play Brick Therapy) based on fidelity data and experience from a large school-based randomised controlled trial
Introduction LEGO® based therapy, a social skills program for autistic children and young people, involves collaborative LEGO® building with adult guidance. This paper examines how...
Quantitative and temporal analysis of autophagy: Differential Response to amino acid and glucose starvation
Autophagy is a highly conserved, intracellular recycling process by which cytoplasmic contents are degraded in the lysosome. This process occurs at a low level constitutively; however, it is induced r...
Threshold analysis of rainfall and groundwater recharge in mitigating drought risks in overexploited groundwater regions
This study examines how rainfall and groundwater recharge can help mitigate drought conditions, using the Standardized Precipitation Evapotranspiration Index (SPEI) as the drought indicator. It focuse...
A prospective evaluation of Johnson & Johnson COVID-19 vaccine on glycemic biomarkers in type 2 diabetes mellitus in Ethiopia
Background People living with Type 2 Diabetes Mellitus (T2DM) face a heightened risk of experiencing severe complications from COVID-19, underscoring the importance of vaccination....
Patient experience of advanced practice physiotherapy within low back pain care pathways in Canada and the United Kingdom: A multiple case-study protocol
Introduction Low back pain (LBP) is the leading cause of disability worldwide, with high prevalence in Canada and the United Kingdom. LBP care pathways offer high-quality, guidelin...
Single-session radiofrequency ablation for the treatment of benign cystic thyroid nodules: A prospective study
Background Benign cystic thyroid nodules are commonly encountered in clinical practice and often require intervention due to compressive symptoms or cosmetic concerns. While ethano...
Intravenous iron for anaemia in pregnancy: A quantitative study of acceptability and feasibility of its integration into routine antenatal care practice in Nigeria
Background Anaemia in pregnancy (AIP), defined as a haemoglobin concentration of less than 11g/dl, is a significant global health issue, especially in resource-constrained settings...
Migration intentions and their impact on healthcare workers in a Lebanese public university hospital amid crises: A mixed-method study
Background The emigration of skilled healthcare workers (HCWs) seeking better opportunities poses major challenges to healthcare systems in low- and middle-income countries. Amidst...
Construction of a depression risk prediction model for hepatitis B patients based on machine learning strategy
Background Hepatitis B (HBV) is a chronic viral infection that can lead to cirrhosis, liver failure, and liver cancer, and has a profound impact on the patient’s mental health. How...
Analysis of the current status and influencing factors of kinesiophobia in tumor patients with peripherally inserted central catheter: A cross-sectional study
Background Peripherally Inserted Central Catheters (PICCs) are widely utilized in tumor patients due to their lower risk of complications, extended indwelling duration, reduced loc...
Implementation of guideline-directed medical treatment for ischemic heart disease management: A knowledge, attitude and practice based cross-sectional survey
Background Guideline-Directed Medical Therapy (GDMT) is central to managing ischemic heart disease (IHD), yet its implementation remains suboptimal in low- and middle-income countr...
Investigating patient navigator impact on older adults’ transitions from acute care: A randomized controlled trial with embedded qualitative component
Background Fall-related injuries such as fractures are on the rise among older adults. Resulting transitions in care from hospital can be complex and place significant pressure on...