PLoS ONE
Articles in this Issue
Expression of Concern: Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
Research on the semantic segmentation of Thangka images via an improved PIDNet
In the digital preservation, restoration, and research of Thangka paintings, real-time semantic segmentation plays a crucial role in rapid image analysis. However, Thangka images exhibit intricate com...
Retraction: Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer’s disease combined with insilico molecular docking
Sperm whales habituate to research vessels engaged in photoidentification
Wildlife research has the potential to affect the subject animals. These effects can be problematic from ethical and management perspectives, as well as for the effectiveness of the research process i...
Development of AI-based dopamine transporter (DAT) image generation technique using early phase [18F]-FP-CIT PET imaging
Objectives To develop and validate a deep learning-based model capable of generating dopamine transporter (DAT) images from early-phase [...
Peripheral leukocyte transcriptomic changes in preweaned Holstein heifer calves with varying stages of Bovine Respiratory Disease
Reduction of morbidity and mortality attributable to Bovine Respiratory Disease (BRD) requires a nuanced approach rooted in understanding associated pathophysiological transcriptomic changes. This stu...
Enhanced production of l-fuculose by Escherichia coli engineered via genome-scale metabolic modeling
l -Fuculose is a rare deoxyketohexose sugar and is a structural isomer of l -fucose, which exhibits skin-lightening, moisturizing, and anti-...
In-silico identification and optimization of MMP-9 inhibitors for cerebral ischemia using structure based virtual screening, MD simulation, and binding free energy calculations
Cerebral ischemia is a leading cause of disability and mortality due to the limited therapies of neuroprotection. Matrix metalloproteinase-9 (MMP-9) plays a major role in cerebral ischemia as it break...
First-passage-based boundary estimation in functional data
We study a functional threshold-crossing setting in which a population-level boundary evolves smoothly over time and crossing events are observed through subject-specific functional trajectories. Moti...
The impact of uncertainty on disclosure of prenatal exome sequencing results: A vignette study among medical students
Introduction We recruited medical students for a study to investigate how they make decisions regarding which hypothetical genetic results to report during pregnancy. We tested how...
Investigating links between co-rumination and personality, social functioning, and emotional well-being in a representative sample of adults
Co-rumination occurs when people discuss problems in-depth, engage in speculation about their problems, and focus on negative affect. Current evidence suggests that co-rumination involves a paradox: w...
Implanted injection port for routine drug delivery to the middle ear in mice
Small molecule drugs designed to rescue disorder-specific mutant proteins causative of progressive sensorineural hearing loss need to be delivered regularly. An example is clarin-1 N48K in Usher syndr...
Nutritional value of hora and mineral-enriched soil for cattle: Evaluation of mineral composition and physicochemical properties in southwestern Ethiopia
Natural mineral water (“ hora ”) and mineral-enriched surrounding soils are potential mineral supplements for cattle, yet comprehensive data on their physicoche...
Modeling vehicle collision risk for the jungle cat in the Hyrcanian forests of Iran: A guide for vehicle collision prevention
Wildlife-vehicle collisions are an important wildlife conservation challenge, especially for carnivores. In Iran, such vehicle collisions pose a major threat to carnivores. The jungle cat (...
Vector characteristics of the sound field based on a single vector hydrophone
The acoustic field in the ocean is a vector field, and its vector characteristics can be gained by a single vector hydrophone. This paper focuses on the vector characteristics of the sonic field, anal...
Media consumption and youth work competencies: Evidence from the Hong Kong youth survey
This study examines how the number of hours spent on different types of media consumption is associated with youth work‑readiness competencies in Hong Kong. Using survey data from 363 tertiary student...
Multimodal anti-Helicobacter pylori effects of Lactobacillus casei HY001: Evidence from in vitro and in vivo studies
Helicobacter pylori ( H. pylori ) is a highly pathogenic microorganism that can cause various gastric diseases. Accumulating evidences have...
In-vitro studies of phytochemical, Antioxidant, Antibacterial and Enzymatic inhibition of Oxalis corniculata whole plant from South Waziristan Tribal District Pakistan
Purpose To analyze phytochemical composition, antioxidant potential, antimicrobial activity and α-glucosidase, cholinesterase and Monoamine oxidase inhibitor...
Real-world validation of a length prediction formula for bedside PICC placement: A single-center retrospective observational study
This study aimed to validate a landmark-based catheter length prediction formula for bedside peripherally inserted central catheter (PICC) placement in a real-world clinical setting, especially in com...
Optimizing breast cancer treatment strategies through fractional-order dynamics: A computational modeling approach
Breast cancer treatment optimization is hindered by heterogeneity, resistance development, and differences among individuals. Most of the existing traditional mathematical models generally do not cons...
Spatial distribution of ticks and tick-borne pathogens in central Hokkaido, Japan and associated ecological factors revealed by intensive short-term survey in 2024
Tick-borne pathogens are transmitted by tick bites to cause infectious diseases in humans and domestic animals. To anticipate tick-borne disease occurrence, a high resolution understanding of infectio...
Cafestol ameliorates diabetic nephropathy via Keap1-Nrf2 axis activation: A novel renoprotective mechanism independent of glycemic control
Diabetic nephropathy is an early complication of diabetes, which triggers lipotoxicity, oxidative stress, inflammation, fibrosis, and apoptosis. This study aimed to investigate the possible protective...
Phenotypic heterogeneity in a batch culture of Chlamydomonas reinhardtii with different light tolerances
Genetic diversity of populations is essential for generating phenotypic variation to allow a flexible response to a shift in environmental conditions. Compared to genetically diverse populations, you...
The influence of stress path and flaw morphology on the failure mechanism and mechanical properties of rock masses
The macroscopic failure of rock masses is essentially the result of the propagation, interaction, and eventual coalescence of internal defects such as flaws under stress. Given the widespread presence...
Uncovering core stemness biomarkers in HBV-HCC through integrated multi-omics
Chronic hepatitis B virus (HBV) infection is a major etiology of hepatocellular carcinoma (HCC), with cancer stem cells (CSCs) playing a critical role in tumor progression and therapeutic resistance....