PLoS ONE
Articles in this Issue
Multidrug resistance and inappropriate empiric therapy as predictors of hospital stay in diabetic foot infections
Objectives This study explored the causative pathogens, resistance patterns, and treatment appropriateness for diabetic foot infections (DFI) at a tertiary care center in Jordan....
The relationships among perceived league product quality, spectator satisfaction, trust, team identification, and loyalty in the Chinese Super League
Objective This study integrates perceived league product quality, spectator satisfaction, trust, team identification, and loyalty into a unified analytical framework to examine the...
Geoglyphs and formative-period activity in the middle Chillón Valley, Peru: Ceramic association and null-model tests of route proximity
Geoglyphs are widespread in arid landscapes, but their chronology and relationship to movement corridors are often difficult to evaluate where direct dating is unavailable. This study examines four ge...
Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment
Each year, tens of millions of individuals sojourn to high-altitude environments (>2500 m), where they face the significant physiological challenge of hypoxia, a condition that often induces a rang...
Detection and genetic characterization of Tembusu virus and other flaviviruses from mosquitoes in Lao PDR
Background Lao People’s Democratic Republic (Lao PDR), located in Southeast Asia and known for its rich biodiversity, is part of a region recognized as a hotspot for emerging and r...
Using the task-technology fit model to examine the use of telemedicine applications by general practitioners in Indonesia: A qualitative study
Telemedicine has been recognized for improving healthcare accessibility and cost efficiency. However, telemedicine applications still face several limitations that must be addressed to better support...
Inequalities in referrals to social prescribing from primary care in England: A retrospective observational study
Background Social prescribing is a growing community health intervention and has been associated with improved patient outcomes. However, the evidence around inequalities in referr...
Challenges and opportunities for plastic versus mixed waste enterprises in Greater Accra and Kisumu: A qualitative study
Consumption of products packaged in plastics is growing in Sub-Saharan African cities, whose populations often lack solid waste management (SWM) services. The informal sector often fills gaps in plast...
Retinal microvascular alterations in children with amblyopia
Purpose To investigate and compare retinal vascular changes, including superficial macular vessel density, foveal avascular zone, and the macular perfusion densities, in amblyopic,...
Bidirectional fusion heterogeneous graph networks for semi-supervised Bitcoin transaction anomaly detection in dynamic transaction graphs
Detecting anomalies in the Bitcoin transaction network is critical for ensuring blockchain security and stability. The network’s heterogeneous structure and dynamic nature, coupled with scarce labeled...
Exploration of comorbidity mechanisms between chronic pain and depression: Machine learning prediction models and SHAP interpretability analysis based on the CHARLS cohort
Introduction With rapid population aging in China, depression among middle-aged and older adults has become a major public health concern. Chronic pain and sociodemographic factors...
Strategy to step on obstacle during cross-country race to minimize overuse injury risk
Background Overuse injuries are a major concern in high school endurance sports such as cross-country running. Methods...
Elevated high sensitivity cardiac troponin T among men with HIV who use stimulants: A cross-sectional study of subclinical cardiovascular injury
People with HIV (PWH) experience elevated cardiovascular disease risk compared to people without HIV. Stimulant use may further increase subclinical myocardial injury among PWH, but data on cardiovasc...
Multi-factor orthogonal optimization and experimental performance study of flow passages in a vertical mixed-flow pump unit
Flow passage optimization is an essential approach for enhancing the efficiency and operational stability of vertical mixed-flow pump units. To address the limitations of the traditional single-factor...
The quantile domain volatility shock transmission between carbon emission trading system and European emerging stock markets: Practical implications for portfolio optimization
This article explores the asymmetrical volatility shock spillovers between European Carbon Emission Trading System (EU-ETS) and European emerging economies’ stock markets by using the Quantile-based V...
Tree species influence soil carbon quality but not total storage across horizons: European beech on Dystric Cambisol and Norway spruce on Entic Podzol
Tree species influence below-ground soil chemistry and microbial communities, both of which are key drivers of soil formation. The study compared soils under native European beech and first-generation...
Elevated ICAM5 as a promising predictor of poor prognosis in bladder cancer via EMT, immune microenvironment, and therapy resistance
Background Bladder cancer, the most common malignancy of the urinary system, is associated with poor prognosis due to its metastatic potential, invasive behavior, and immune evasio...
Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023)
The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the p...
Sub-millimeter quantification of alveolar bone loss using automated 40 MHz high-frequency ultrasound: A proof-of-concept ex vivo validation study
This proof-of-concept study evaluated the performance of high-frequency ultrasound (HFUS, 40 MHz) for monitoring changes in alveolar bone loss and determining its detection capability and measurement...
Biochemical and antidiabetic properties of Elaeocarpus angustifolius Blume: In vitro, In vivo, and In silico insights
Diabetes poses an utmost threat to human health; significant progress in the discovery of antidiabetic drugs has been made, but their side effects cannot be ignored. As a plant-based alternative, this...
Trends in HPV vaccination initiation and completion among U.S. adolescents aged 13–17 years, 2021–2023: Findings from the National Immunization Survey–Teen
Human papillomavirus (HPV) vaccination is a key strategy for preventing HPV-related cancers, yet series completion among U.S. adolescents remains below national public health goals. This study analyze...
Association of the planetary health diet score with obesity, high blood pressure, dyslipidemia, and cardiometabolic risk markers: Using data from the 2016–2020 Korea National Health and Nutrition Examination Survey
Noncommunicable diseases (NCDs) remain the leading cause of death worldwide, with unhealthy diets and insufficient physical activity as major contributing factors. The Planetary Health Diet is a susta...
Modeling the effects of meteorological factors and media-driven public awareness on seasonal influenza outbreaks
Seasonal influenza remains a significant public health challenge in China, with its transmission dynamics influenced by both environmental conditions and media-driven public awareness. In this study,...
Association between hypnotic medication use and in-hospital falls among older adults: A multicenter landmark analysis
Background Hypnotics are frequently prescribed to hospitalized older adults, but comparative evidence on fall risk across hypnotic classes remains inconsistent, partly due to confo...
Effects of extra training with active cycle of breathing technique relative to whole-body breathing exercise in older adults with stable COPD
Objective To examine the effects of extra training with active cycle of breathing technique (ACBT) as compared to whole-body breathing exercise (WBBE) in older adults with stable c...