PLoS ONE
Articles in this Issue
Structural consistency in AI governance: A PMC index assessment with evidence from China’s central-level policies
The structural coherence of policy design has become an increasingly important issue in artificial intelligence (AI) governance. This study evaluates the structural consistency of China’s central-leve...
Comparative impact of insect growth regulators on mortality and development of Amrasca biguttula (Hemiptera: Cicadellidae)
The two-spot cotton leafhopper, Amrasca biguttula (Ishida) (Hemiptera: Cicadellidae), recently detected in the United States, represents an emerging threat to c...
A system-wide snapshot: A multi-campus survey of open source contributors at the University of California
Academic open source contributors face a wide array of challenges, making it difficult for universities, support staff, and funders to determine which needs they should prioritize. To help address thi...
Progress and gaps in childhood immunization among two-year-olds in Ghana (1993–2022): A trend and equity analysis
Background Immunization remains a cornerstone of child survival and population health. While Ghana has made significant strides in vaccine delivery over the past three decades, gap...
Focusing on legal cases: Automatic classification of legal documents with sentence embeddings and deep learning models
The justice system is indispensable to any society as it enforces the rule of law, safeguards fundamental rights, and ensures the equitable resolution of disputes through structured legal frameworks....
Construction of a public health emergency information system framework: A case study of Zhuhai city, China
Background A public health emergency information system serves as a critical tool for collecting and analyzing data from sudden public health events, thereby providing a scientific...
A U-Net model for epidermal segmentation in optical coherence tomography images of actinic keratosis
Actinic keratosis (AK) is a pre-cancerous skin lesion typically caused by excessive exposure to ultraviolet light. Optical coherence tomography (OCT) can provide sub-surface information relevant for l...
From cheap entertainment to expensive pleasure: Cinema-going habits and motivations of young people in Türkiye
This study examines the cinema-going habits and motivations of university students in Türkiye from a class-based perspective. This study addresses a gap in the literature by examining cinema-going mot...
Mapping the landscape of psychological literature on threat from 1961 to 2023 through structural topic modeling
The past decades have generated a substantial volume of psychological literature on threat. However, the absence of systematic cross-field synthesis has resulted in limited understanding of major rese...
The effect of yttrium addition on the ratcheting behavior of magnesium
This study provides an in-depth investigation into the influence of yttrium (Y) addition on the ratcheting behavior of magnesium (Mg) alloys under asymmetric cyclic loading. Although pure Mg exhibits...
Genetic association and computational analysis of CYP2R1 gene polymorphisms rs2060793 and rs12794714 with vitamin D deficiency and acute myocardial infarction in the Bangladeshi population: A case control study
Acute myocardial infarction (AMI) remains a leading cause of cardiovascular morbidity and mortality worldwide. Emerging evidence highlights vitamin D as a critical determinant of cardiovascular health...
Topological data analysis for predicting disease outbreaks in humanitarian settings: A machine learning approach
Background Humanitarian settings are highly vulnerable to infectious disease outbreaks because displacement, crowding, disruption of health services, insecurity, and inadequate wat...
Single-cell profiling of kinase substrate phosphorylation by single-molecule imaging
Protein phosphorylation regulates diverse cellular processes, yet its analysis at the single-cell level remains challenging due to the low abundance of phosphoproteins. Here, we present a highly sensi...
Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone –induced multiple sclerosis model
Multiple sclerosis (MS) is characterized by chronic neuroinflammation and progressive demyelination, with current therapies failing to adequately address both processes simultaneously. Helminth-derive...
Correction: Earliest evidence for invasive mitigation of dental caries by Neanderthals
Gender differences in provider practice characteristics and medicare payment & services among diagnostic radiologists
Background Gender-based differences in representation, practice settings, sub-specialty, billings, and payments among radiologists are poorly understood....
Size-dependent mechanical performance and defect sensitivity in T4,4,4-graphyne nanosheets: A comprehensive multi-parameter investigation
The mechanical performance of T4,4,4-graphyne was systematically investigated using molecular dynamics (MD) simulations. The study explores the effects of structural size, temperature, defect density,...
Perspectives on preconception care in Ethiopia: Social, cultural, and structural determinants
Background Although Ethiopia introduced its first national preconception care (PCC) guideline in 2024, PCC remains rarely integrated into routine practice, and existing studies hav...
Negotiating illness through faith: Religious narratives of cancer etiology among patients and caregivers in Addis Ababa, Ethiopia
Cancer has become a major global public health threat, and individuals diagnosed with cancer and their family caregivers often seek to understand their illness experiences. Religious, spiritual, and s...
Correlation of single-round strokes & performance indicators: Paris Olympic elite female golfers
Despite golf’s Olympic reinstatement, quantitative research on elite female Olympic golfers remains scarce, with most studies focusing on tour or amateur players. This study aimed to quantify relation...
Targeted Muscle Reinnervation (TMR) or Regenerative Peripheral Nerve Interface (RPNI) for pain prevention in patients with limb amputation: A protocol for a systematic review and meta-analysis
Introduction Regenerative Peripheral Nerve Interface (RPNI) and Targeted Muscle Reinnervation (TMR) have demonstrated superior outcomes compared to classical amputation in prophyla...
Vertical distribution and migration of microplastics in soils from Fars Province, Southwest Iran
Microplastics (MPs) in soils are becoming increasingly recognised as important terrestrial contaminants, yet their vertical distribution below the plough layer remains poorly understood. Here, we exam...
Cumulative metabolic stress (microfilarial infection + moult) constrains the expression of carotenoid-based honest signals in breeding male village weavers (Ploceus cucullatus) of Amurum Forest Reserve, Nigeria
In wild birds, the breeding season involves a convergence of metabolically demanding life-history stages, including reproduction, moult, and immune defense. We investigated the relationships between m...
Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease
Neutrophil extracellular traps (NETs) are suggested to play a role in chronic kidney disease (CKD). Whether they are indeed involved in the pathogenesis of animal models of CKD has not been proved. Th...
Differential analysis of Short chain fatty acids incubation in autistic organoids based on transcriptome sequencing
Autism spectrum disorder (ASD) is characterized by difficulty with social communication and restricted, repetitive patterns of behavior, interest, or activities. We hypothesized that a dysregulation i...