PLoS ONE
Articles in this Issue
Seasonal metabolic and growth responses of grazing beef heifers divergent in residual feed intake
This study involved 41 crossbred, black-hided beef heifers that were measured in a drylot for residual feed intake (RFI) at 11 ± 1 months of age and classified into more (LOW-RFI; n = 21; –0.96 ± 0.70...
Muscimol injection into the ventral posterolateral nucleus of the thalamus impairs tactile reward-seeking behavior but preserves affective vocalization in male rats
Ultrasonic vocalizations (USVs) are a useful tool for evaluating emotion and motivation in rodents. Rhythmic stroking in rats induces positive affective 50-kHz USVs and reward-seeking behavior. This r...
Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics
Interindividual variability in sertraline exposure is substantial and may be influenced by genetic variation in drug-metabolizing enzymes as well as by concomitant medications that modify enzyme activ...
The impact of physical therapy direct access policy on opioid shipments and opioid-related deaths: A difference-in-differences analysis
Background We exploit state-level policy changes for physical therapy direct access to estimate the effect of enacting direct access physical therapy policy on per-capita opioid pi...
Gender and residential differences in sleep quality among Chinese adolescents aged 13–18 years
Background Good sleep is essential for healthy adolescent development, yet declining sleep quality among Chinese adolescents has become a nationwide public health concern. Resident...
Cost analysis of a nationwide typhoid conjugate vaccine campaign in Burkina Faso
Background In Burkina Faso, typhoid fever remains a major public health concern, particularly among children under 15. In January 2025, a nationwide campaign introduced the typhoid...
Promoting shared decision-making in colorectal cancer screening in primary care: A cluster randomized controlled trial
Introduction In Switzerland, primary care physicians (PCP) prescribe colonoscopy for colorectal cancer (CRC) screening rather than offering a choice between colonoscopy and faecal...
Spatial distribution and risk assessment of dengue incidence at district level across major climatic zones in India
Over the past decade, dengue incidence has been steadily increasing across the different climatic zones of India. The role of climatic variability in the spatial and temporal distribution of dengue at...
Indirect state-level estimation of sexual minority adolescent populations by sex, age, and race/ethnicity using random forests
Purpose Estimating population sizes of adolescents who identify as lesbian, gay, or bisexual (LGB) is important for addressing health needs and disparities. Most states have Youth...
Etiology of severe acute respiratory infections among adults in northern Thailand using multiplex PCR: A post-COVID-19 surveillance study (2023–2024)
Introduction The COVID-19 pandemic disrupted the circulation patterns of respiratory viruses. In tropical regions like Thailand, ongoing surveillance is essential to understand the...
Replicative and stress-induced premature senescence distinctively affect the endothelial anticoagulation capacity
Aging is strongly associated with an increased risk of morbidity and mortality from multiple diseases, including thromboembolic disorders. Endothelial dysfunction is considered a key contributor to ag...
Embodied intelligence-driven adaptive collaboration in supply chains: A four-dimensional synergy framework and mechanism analysis
Existing research focuses on data-driven algorithm optimization but overlooks the embodied nature of supply chains as physical and digital integrated systems, leading to a disconnect between AI and ph...
Association between ICU-level variation in arterial blood gas utilization and in-hospital mortality: A retrospective cohort study using the Japanese Intensive care PAtient Database registry
Background The role of arterial blood gas (ABG) testing in the intensive care unit (ICU) remains debated within the “less is more” paradigm. While unnecessary testing may pose risk...
Early mortality risk stratification in childhood bacterial meningitis using cerebrospinal fluid glucose and protein levels and their combinations: A multicontinental cohort study
Background Bacterial meningitis remains a major cause of death and neurological disability in children worldwide, particularly in low-resource settings where access to intensive ca...
Correction: Better start to bilingual development: Bridging parental beliefs and science through early intervention for Polish families living in Norway
Correction: Prediction of the ectasia screening index from raw Casia2 volume data for keratoconus identification by using convolutional neural networks
Design of Urban resilience model in emergency situations
In response to the current demand for urban resilience in emergency situations, we have developed an urban resilience assessment system for responding to sudden natural disasters based on housing data...
Mechanical properties and energy evolution characteristics of fissure sandstone under the interaction between water and fissures
To investigate the mechanical properties and damage evolution of fissure sandstone under the interaction between water and fissures, this study performed uniaxial compression tests on sandstone specim...
Correction: The structure of spontaneous speech changes in Alzheimer’s disease: Crosslingual evidence from English and Greek
Can heat stress affect the psychophysiological responses and locomotor demands of young soccer players during small-sided soccer games?
The study compared the effects of three different heat stress conditions on the psycho-physiological responses and locomotor demands of young players in different small-sided soccer games (SSGs). Sixt...
Biomedical engineer density per hospital bed: A medical device quality indicator for Mexican Healthcare System
Background The measurement of health indicators that enable the estimation of a system’s capacity to provide adequate patient care constitutes a highly relevant factor in the evalu...
Correction: Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates
Prevalence of diphtheria and antimicrobial-resistant wound infections among asylum seekers in Heidelberg, Germany, August–October 2024
Purpose In the second half of 2022 and 2023, an increase of diphtheria cases among asylum seekers was observed in Europe, with 120 cases reported in the stat...
Expression of Concern: Computational modeling and analysis of medical resource shortages in hospital alliance: A simulation-driven approach
What do youth need to know about puberty? A scoping review protocol to identify puberty education competencies
Introduction Puberty is a key transition point in adolescents’ lives that plays a foundational role in shaping health behaviors and outcomes across one’s life course. This period h...