PLoS ONE
Articles in this Issue
Type 2 diabetes and cancer: A retrospective longitudinal comparative cohort study of disease sequence and comorbidity profiles
Type 2 Diabetes Mellitus (T2DM) and cancer are major non-communicable diseases that impose a substantial dual burden when they co-occur. However, this dual burden remains understudied and the majority...
The association between upper limb function, physical exercise, and cognitive ability among empty-nest elderly in China: A cross-sectional study based on CLHLS
Background The rapid aging of China’s population poses serious challenges to the cognitive health of older adults living without co-resident children (empty-nest older adults). Cur...
Feasibility of mechanomyography-based fatigue classification for passive lower-limb exoskeleton evaluation: A pilot study
Mechanomyography (MMG) enables non-invasive monitoring of muscle mechanical activity, while its utility in time-resolved fatigue detection during dynamic human–exoskeleton interaction remains underexp...
Dynamic effects of China’s national volume-based procurement on generic drug consistency evaluation: An interrupted time series analysis
Objectives China’s national volume-based procurement (NVBP) policy uniquely requires the generic drug consistency evaluation (GCE) for generic drugs on the purchase list. It employ...
Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study
Background Neurodegenerative diseases significantly impact brain health in older adults, and although dietary vitamin C intake has been associated with a reduced risk of cognitive...
Correction: The association between platelet-to-albumin ratio and diabetic peripheral neuropathy: A cross-sectional study in the Chinese population
A pilot randomized clinical trial of the Skills to Enhance Positivity (STEP) group intervention for young adults with depression: Examining feasibility and acceptability
Addressing the pressing concern of rising rates of depression and suicide in young adults, the present study explores the feasibility of adapting the Skills to Enhance Positivity (STEP) intervention a...
Diverse coping strategies for food insecurity: A qualitative study of economically precarious households in India in the context of COVID-19
Objective The study examines how households in two Indian states managed food insecurity in the context of COVID-19, focusing on differences between migrant and non-migrant househo...
Shared decision making in Eosinophilic esophagitis: Integrating physician and patient perspectives
Background and objectives Shared decision making (SDM) is a patient-centered approach for conditions where multiple, preference-sensitive treatment options exist and there is no si...
Laplace Transform–Based Nonparametric Test of Exponentiality against DMRL class with preservation under the Homogeneous Poisson Shock Model and applications in survival analysis and reliability
This paper introduces a novel, computationally efficient nonparametric test for assessing the null hypothesis of exponentiality against alternatives belonging to the Decreasing Mean Residual Life (DMR...
Four methods for estimating hepatitis C incidence using extant testing data
Background Accurate estimation of hepatitis C (HCV) incidence is crucial for measuring progress towards HCV elimination targets set by the World Health Organization (WHO). Extant H...
Modification of pre-operative order set to reduce PACU stay times for outpatient benign gynecological surgery
A quality improvement project was implemented at a single medical center’s outpatient benign gynecological surgery division to address prolonged post anesthesia care unit (PACU) stays (defined as grea...
Causes of medication errors in community pharmacies: A meta-ethnography and systematic review
Introduction Medication errors are a leading cause of patient harm and account for thousands of deaths and injuries annually. While medication safety efforts have primarily targete...
Experience implementing a sporotrichosis surveillance and control program in free-roaming cats on a university campus
Sporotrichosis is an emerging zoonosis with growing impact in Brazil’s urban areas, aggravated by the absence of effective public health policies and standardized surveillance protocols, especially fo...
Verification of historical sketches via one-class learning on compact feature representations
Historical sketch authentication is challenging because securely attributed reference sets are often small, and stylistic evidence is carried primarily by line, texture, tonal variation, and mark-maki...
Microbiome analysis of bronchoalveolar lavage (BAL) specimens from immunocompromised patients with pneumonia compared to those from healthy volunteers
Background Metagenomic sequencing of bronchoalveolar lavage (BAL) specimens is increasingly being applied for the diagnosis of lower respiratory tract infections, offering agnostic...
A machine learning–coupled APSIM model pipeline for projected oil palm yield in Surat Thani, Thailand
Accurate and timely forecasts of oil palm yield are essential for both short-term farm management and long-term adaptation planning, yet their reliability is often constrained by the coarse spatial re...
HIV, nephrotoxic medications, and chronic kidney disease: Prevalence, risk factors, and mediation analyses among people with and without HIV enrolled in the Multicenter AIDS Cohort Study (MACS)/ Women’s Interagency HIV Study (WIHS) combined cohort study
Background Chronic kidney disease (CKD) affects over 37 million adults in the United States, and people living with HIV (PLWH) are at greater risk for progression to end-stage kidn...
Prescription patterns of inhaler medications from 2017 to 2023: A retrospective study using Ontario administrative healthcare data
Background Inhalers are essential for respiratory disease management, but commonly used metered-dose inhalers (MDIs) can often be replaced, when clinically appropriate, with lower-...
Human papillomavirus genotypes and factors associated with major cervical smear abnormalities in a sickle cell endemic area of Kisangani, Democratic Republic of the Congo
Background Cervical cancer due to high-risk human papillomavirus (HR-HPV) is the leading gynecological cancer in Sub-Saharan Africa and in the Democratic Republic of the Congo (DRC...
Specialized marine exploitation on African islands: A multiproxy archaeological analysis of the Playa Chica site, Gran Canaria (11th–13th CE)
The Canary Islands, settled by Berber communities from Northwest Africa during the first millennium CE, offer a privileged window into coastal economies and early maritime adaptations that remain poor...
The emergence of NDM-1, IMP-7, IMP-26, IMP-62, IMP-76, VIM-4 and VIM-5 producing Pseudomonas aeruginosa strains, identification of a novel sequence type (ST3891) and analysis of virulence genes from a Malaysian tertiary hospital
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a medically crucial nosocomial pathogen causing significant mortality in patients with weakened immune syste...
Characteristics of long stay home care clients’ acute care use who live with frailty in Alberta, Canada: A retrospective cohort study
Objective To describe the characteristics of long stay home care clients’ acute care use who live with frailty, and to compare associated factors for hospitalizations....
From platform carnival to official discourse: How “truth” is produced in Chinese online news
How is “truth” sustained amid algorithmic and political constraints? This study explores the process by which “truth” is negotiated and stabilized in China’s online journalism. Drawing on Actor-Networ...
Burden and temporal trends of female-specific cancers in China: A systematic analysis of the 2023 global burden of disease study
Background Female-specific cancers represent a substantial public health challenge in China. This study was designed to evaluate temporal trends and generate future projections of...