PLoS ONE
Articles in this Issue
Human α-galactosidase A is stimulated by folic acid supplementation – possible implications in Fabry disease management
Fabry disease (FD) in an inherited lysosomal storage disorder with severe lifelong issues if not therapeutically managed. The disorder results from mutation in the gene GLA...
Mumtathil: Automatic PDPL compliance identification system of Arabic privacy policies documents
In the digital era, the extensive collection and use of personal data by websites and applications has prompted various countries to implement data protection laws. The Kingdom of Saudi Arabia introdu...
Research on user acceptance intention of artificial intelligence generated content for museum cultural and creative products
Recent advancements in the field of artificial intelligence have driven the rapid adoption of artificial intelligence generated content in the cultural and creative industries, making it a core driver...
Phytochemical composition, antioxidant potential, and enzyme inhibitory properties of Onosma thracica extracts: A comparative study of extraction methods
Onosma thracica is a promising natural source of bioactive phenolic compounds, including flavonoids, yet the influence of extraction technique on its chemical profile and biologica...
Quality of follow-up care for premature infants in primary health care: A cross-sectional study from nurses' perspective in Paraná state, Brazil
Background Prematurity affects approximately 10% of births worldwide and represents the leading cause of mortality in children under five years of age. The considerable variability...
Structural bioinformatic studies of eight integral transmembrane NADPH oxidases and their AlphaFold 3 predicted QTY analogs with reduced hydrophobicity
The NADPH oxidase (NOX) family comprises integral membrane-bound enzymes responsible for generating reactive oxygen species (ROS), with critical roles in immune defense, vascular regulation, and cellu...
Gaelic games coaches’ attitudes towards, awareness of and use of injury prevention exercise programmes
Purpose Gaelic games (GG) are multidirectional, evasive sports with unpredictable high-intensity activity. Lower extremity injuries are common. Injury prevention exercise programme...
Development of an indirect ELISA for the detection of venezuelan equine encephalitis virus specific antibodies in horses
Venezuelan equine encephalitis virus (VEEV) is a re-emerging zoonotic pathogen to which equines are most susceptible mammals hosts with a high mortality rate raging from19 to 83%. The virus, transmitt...
Long term evaluation of the safety and efficacy of local cooling anesthesia during intravitreal injections: The COOL-2 Trial
Background/Objective To evaluate the safety and effectiveness of a medical device providing cooling anesthesia to the eye as local anesthesia for intravitreal (IVT) injections....
Learning strategies, study behaviors, and academic performance among medical students in Jordan: A cross-sectional study
Academic performance in medical education is influenced by multiple factors, including learning strategies and study behaviors. However, the extent to which these factors are associated with academic...
Surface modification of carbon-based adsorbents derived from coal gasification slag for the efficient adsorption of trimethoprim
Given that pristine water bodies are irreplaceable for maintaining ecosystem homeostasis, the remediation of antibiotic-contaminated aquatic systems has emerged as a pivotal challenge. This research u...
Barriers, motivations, and understanding: A qualitative study on the acceptability of an academic weight management program
Introduction Obesity is a critical health issue, and West Virginia is a state with an exceptionally high obesity rate. There are evidence-based medical guidelines for treating obes...
Welcome to paradise: Measuring vegetation responses to tourism and agricultural activity using Leaf Area Index in the Galapagos Islands
The Galapagos Islands are globally recognized for their biodiversity, yet the high volume of annual visitors and dependence on food imports raise significant concerns regarding human-induced environme...
Geospatial variation and machine learning approaches to predict open defecation practice in Zambia
Background Open defecation is the disposal of human feces in fields, bushes, forests, open waterways, beaches, and other open areas. It worsens the environment, contaminates drinki...
Effects of a school-based ACT program on motivation, physical activity participation, motor competence, and physical performance in physically inactive female adolescent students
Adolescents face internal barriers like low self-confidence and psychological discomfort that limit physical activity. Adolescence offers a key window to enhance intrinsic motivation. Acceptance and C...
Fusogen-induced recovery of spinal cord function and morphology after complete transection
Spinal cord injury is a critical issue in neurosurgery, lacking established clinical methods for functional restoration. This study reports the effects of a fusogen sealant, composed of polyethylene g...
Comparison of local large language models for extraction of signs and symptoms data from electronic health records
Electronic health records (EHRs) provide a large source of data that can be used for research purposes. Extraction of information from unstructured clinical notes in EHRs can be automated by large lan...
Optimising the Delphi survey method during core set development: The impact of summarised feedback on stakeholders’ prioritisation of core data items and consensus
Background Core outcome sets are an established method for standardising the collection, measurement and reporting of treatment outcomes in effectiveness trials. Using Delphi surve...
Effectiveness of shortwave diathermy in patients with chronic low back pain: A study protocol for a randomised, single-blinded, multicentre clinical trial
Background Chronic low back pain (CLBP) is a leading cause of disability worldwide and a major public health concern in low- and middle-income countries such as Bangladesh. Althoug...
A novel adaptive quasi-Newton-type update and its global convergence without Lipschitz condition for constrained system of nonlinear monotone equations
This paper presents a new iterative method with a restart feature for solving constrained system of nonlinear monotone equations. The scheme, which is a double-parameter method, was initiated by consi...
Clinical usefulness of repeated sputum culture for the identification of pneumonia pathogens: A retrospective study
Sputum culture is essential for identifying pneumonia pathogens, but its sensitivity remains limited. This study evaluated the clinical utility of repeated sputum cultures and factors associated with...
Clinical outcomes of critical limb ischemia in Buerger disease: A contemporary analysis from an academic referral center in Jordan
Objective Buerger disease (BD), thromboangiitis obliterans , is a rare occlusive peripheral arterial disease affe...
Generalized escape criteria for fractals via convex viscosity approximation iterations
In this manuscript, we present the generation of Mandelbrot sets, Julia set fractals, and Biomorphs using a two-step viscosity approximation method applied to the complex function...
Fresh aboveground net primary productivity of Tibetan grasslands: Responses of different plant functional groups to climate change and human activities and implications for ecosystem management
Uncertainties remain regarding how climate change and human activities affect the aboveground net primary productivity (ANPP) of grassland ecosystems, particularly the differential responses of distin...
To the moon: Retail investor attention and sentiment across asset types in online media
Social media facilitates community building for users of varied and broad interests. Personal and retail (individual non-professional) investment communities have grown popular, and some engage in com...