PLoS ONE
Articles in this Issue
Factors associated with procedural difficulty and major adverse events during transcatheter closure of the patent ductus arteriosus
Transcatheter closure of the patent ductus arteriosus (PDA) is widely accepted as an alternative to surgical ligation. However, major complications are uncommon. Therefore, procedural difficulty, incl...
Real-world implementation and cost impact analysis of Oncotype DX testing in early-stage breast cancer
Background The decision on appropriate adjuvant treatment for patients with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2 -negative (HER2-) early bre...
The endurance effort on a mechanical treadmill does not activate the complement system among trained young women
The complement system (CS) plays a crucial role not only in pathogen-related immune responses but also in immunomodulatory effects associated with increased levels of damage-associated molecular patte...
The oral and lower airway microbiota and coronary heart disease in COPD patients and controls
Background Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) are major causes of morbidity and mortality, with shared risk factors and often co-occurrin...
Associated factors of myopia in a Portuguese sample of adolescents: Parental history and school-related lifestyle
Purpose This study aimed to investigate the interaction between parental myopia and school-related lifestyle patterns, and myopia in a sample of Portuguese adolescents. Based on pr...
Aptamer-functionalized stiff hydrogel for enhanced BMSC enrichment and osteogenesis
To address the need to both enrich stem cells and direct their osteogenic fate in bone tissue engineering and bone regeneration, we developed a stiffness-gradient hydrogel (~4.5– 3...
Retraction: Automated brain tumor diagnostics: Empowering neuro-oncology with deep learning-based MRI image analysis
Postbiotic effects of Enterococcus faecium JB00008 on gut health and IBD vaccination in broiler chickens
Feeding various probiotic lactic acid bacteria, including Enterococcus faecium , can alleviate intestinal inflammation and improve gut health in animals. Recent...
Detection of critical transition states in complex diseases based on distance correlation coefficient
During the development of many complex diseases, biological systems may pass through an unstable critical transition state before disease onset or further deterioration. Timely detection of this state...
Characterization of a novel lncRNA RP3-340N1.2 and its association with a miR-4650-5p/SHC1-related regulatory network in lung adenocarcinoma
Long noncoding RNAs (lncRNAs) are increasingly recognized as regulators of cancer-related biological processes. However, the functional significance of many lncRNAs in lung adenocarcinoma (LUAD) remai...
Antimicrobial resistance patterns of Escherichia coli isolated from raw cow milk and, from clinical specimens in a tertiary institution, Uganda – A cross sectional study
Background Inappropriate antibiotic use in animal husbandry contributes to the emergence of resistant bacteria, which may enter the human population through the food chain....
Prevalence, practices, and maternal perceptions of traditional uvulectomy among sudanese children and adolescents: A community-based cross-sectional study
Background Traditional uvulectomy (TU) is the removal of the uvula, either partially or totally, by the traditional healer. It is prevalent in sub-Saharan Africa, driven by cultura...
Effectiveness of flipped classroom pedagogy: A mixed-methods analysis of adult continuing education—Case study, Egyptian context
This mixed-methods study investigated the effectiveness of a flipped classroom model in an adult English as a Foreign Language (EFL) continuing education program in Egypt. A total of 297 learners part...
Therapeutic potential of flavonoids and rutin against inflammation-induced on a huntington animal model
This study tested the hypothesis that flavonoids (diosmine, hesperidin and rutin®) play a protective role in the brain and duodenum against 3-Nitropropionic acid (3-NPA) free radical induced inflammat...
The impact of ethnic self-identity on post-migration social integration of young rural to urban migrants in China: An interpretative phenomenological analysis
Background Post-migration social integration is a pressing concern for young ethnic-minority migrants in urban China. This study examines how ethnic self-identity shapes this integ...
Computational and experimental evaluation of Pisolithus arhizus metabolites targeting major efflux pumps of mastitis-associated Staphylococcus aureus
Antimicrobial resistance (AMR) in pathogenic bacteria, particularly Staphylococcus aureus , is an increasing global concern in veterinary medicine. The present...
Hematological parameters and associated factors among adult patients with type 2 diabetes mellitus attending selected hospitals in Garowe, Puntland, Somalia: A comparative cross-sectional study
Background Diabetes mellitus is characterized by elevated blood glucose levels resulting from inadequate insulin production or ineffective insulin utilization. Type 2 diabetes, the...
Dysmenorrhea Symptoms Interference Scale (DSI) in Serbian - Translation and psychometric properties evaluation
Background and Objective Dysmenorrhea, painful menstruation, affects 20–90% of women and it can significantly impair their quality of life. To evaluate the severity and consequence...
Synchronized by photoperiod: Shedding light on flowering seasonality in Acrocomia species (Arecaceae)
Interest in the oilseed palm genus Acrocomia has grown due to its potential as a sustainable alternative to the African oil palm ( Elaeis gu...
Covid-19 related excess mortality: An analysis by age for selected countries
Background Measures of excess mortality are generally regarded as providing the best metric for countries’ experience during the Covid pandemic of 2020–2022. Such measures, however...
Social and psychological capital in relation to social well-being among university students in Maragheh: A cross-sectional study
Background Social Capital and Psychological Capital are important determinants of individuals’ Social Well-Being. However, limited evidence exists on how these factors interact amo...
Targeted metabolomic profiling of RAW 264.7 cells infected with Brucella canis identifies time-dependent metabolic changes
Canine brucellosis caused by Brucella canis is gaining public-health relevance as companion-dog ownership and close human–animal contact increase. Yet mechanist...
Effects of the competition schedule in major-competition years on performance in major-competition: Evidence from speed- and power-type track and field events
Objective This study aimed to examine the association between competition schedules in major-competition years (Olympic or World Championships years, M-Years) and performance in ma...
Temperament, personality and decision-making accuracy in handball referees
Accurate decision-making is essential for effective handball officiating, yet little is known about how stable psychological traits relate to referees’ decision-making accuracy. This study examined wh...
A survey of UK and Irish veterinary and veterinary nursing Students’ engagement with small animal nutrition information
The global prevalence of diet-related non-communicable disease is rising, along with popularity of unconventional and alternative diets and the availability of unsubstantiated information. Considerabl...