PLoS ONE
Articles in this Issue
In vitro and in vivo evaluation of antioxidant activity, acute toxicity, and antihyperglycemic effect of individual and binary mixtures of crude methanolic extracts of Cucurbita moschata and Bidens pilosa
Background Bidens pilosa (BP) and Cucurbita moschata (CM) are used to treat diabetes tradit...
Computing the Skyline Query over a k2-tree compact data structure
This study aims to explore the feasibility of executing Skyline Queries—used to identify optimal data points based on multiple criteria—within compact data structures. While existing algorithms typica...
Blood urea nitrogen to albumin ratio and mortality in critically ill patients with cardiogenic shock
Purpose Given the high mortality associated with cardiogenic shock (CS), this study aimed to evaluate the association between the blood urea nitrogen-to-albumin ratio (BAR) and mor...
What topological and geometric structure do biological foundation models learn? Evidence from 141 hypotheses
When biological foundation models like scGPT and Geneformer learn to process single-cell gene expression, what kind of geometric and topological structure forms in their internal representations? Is t...
The epidemiology of the viral hepatitis in Brazil: A scoping review
Background Brazil has advanced toward eliminating viral hepatitis by 2030 through broad prevention, diagnosis, and treatment policies. Yet substantial gaps persist across the care...
Automated CT dataset generation as a novel concept for verification of backshape-to-spine approach and Cobb Angle Estimation
Background Adolescent idiopathic scoliosis is a condition that affects up to 3% of adolescents. Although radiographic imaging is the gold standard for diagnosis and monitoring, rep...
Day-ahead active and reactive power scheduling of wind turbines and battery energy storage systems for power loss and CO2 emission reduction in AC microgrids
This paper proposes a day-ahead scheduling framework to analyze and optimize the impact of the coordinated active and reactive power management of wind turbines (WTs) and battery energy storage system...
A robust cross-crop disease detection framework based on SIS-YOLOv11 with climate-adaptive mechanisms
Plant disease detection under complex climatic conditions and cross-crop scenarios remains a critical challenge. To address this, we propose a novel SimAM-Inception-StyleRandomization (SIS)-YOLOv11 al...
Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts
Altered sensitivity to environmental stimuli is a core feature of autism spectrum disorder (ASD) that may drive vulnerability to stress-related and anxiety disorders. To investigate this relationship,...
Study on electrochemical corrosion behavior of gray cast iron processed via laser cavitation peening
Laser cavitation peening (LCP) is a novel material surface treatment method. In this study, we investigated the electrochemical corrosion performance of LCP-treated HT250 gray cast iron, with and with...
Sex and the clock: Exploring sex differences in chronotype and circadian behavior among healthy older adults
This study aimed to compare subjective and objective circadian measures with a focus on sex differences and cognition in healthy older adults. A total of 126 participants (aged 65–90 years) completed...
An 8-week jump training did not boost effort value or the willingness to exert effort in a student sample
Physical inactivity remains highly prevalent, partly driven by the aversive nature of effort. However, effort can also be experienced as rewarding, which is associated with greater overall physical ac...
Factors associated with low-density lipoprotein control in outpatients with myocardial infarction: A hospital-based study
Discrepancies in factors influencing low-density lipoprotein cholesterol (LDL-C) control in patients with myocardial infarction have been documented in existing literature. Assessing LDL-C control and...
Signal mining and analysis of adverse events associated with Isotretinoin: A 20-Year real-world pharmacovigilance study based on FAERS and EudraVigilance databases
Objective To systematically characterize the post-marketing safety signals of isotretinoin using real-world data from the U.S. FDA Adverse Event Reporting System (FAERS), with inde...
A pilot study on the impact mechanism of internal and external leading variables on consumers’ purchase intention and healthy dietary behavior of plant-rich foods
This study integrates the TPB with Information Processing Theory and Sensory Marketing Theory to investigate the influence mechanisms of Plant-Rich Foods(PRF) attributes and their packaging on consume...
Editorial Note: Multi-objective optimization using improved NSGA-II for integrated process planning and scheduling problems in a machining job shop for large-size valve
Developing comprehensive perinatal quality of care instruments in Mexico: An inclusive, multidisciplinary, and culturally sensitive approach
Ensuring high-quality care during pregnancy, childbirth, postpartum, and the newborn period is essential for reducing maternal and neonatal morbidity and mortality. In Mexico, a significant gap exists...
Exploring the relationship between supervisory support, self-efficacy, and satisfaction among nursing students in Saudi Arabia
Background Supervisory support during clinical placements is central to nursing students’ professional development. Professional self-efficacy, students’ confidence in performing c...
Bone-conducted ultrasonic auditory brainstem response thresholds in a mouse model of cisplatin-induced hearing loss
Cisplatin is widely used in cancer treatment but can cause hearing loss, predominantly at high frequencies. Auditory responses to bone-conducted ultrasonic stimulation have been proposed as a potentia...
Respiratory pattern change in female and male runners by respiratory tract restriction using a respirator
Respiratory protective equipment, particularly filtering facepiece respirators (FFRs), are increasingly used during physical activity, yet their influence on breathing mechanics remains unclear. This...
Quality improvement intervention for school-based support teams for adolescents’ mental health in selected secondary schools in Gauteng: A study protocol
The prevalence of mental health disorders among adolescents poses a significant global health challenge, with approximately one in seven individuals aged 10–19 affected. The limited access to effectiv...
Clustering recovered 18650 lithium-ion cells to improve homogeneity in second-life battery pack construction
Second-life use of lithium-ion batteries depends on assembling packs from recovered cells that behave as consistently as possible; however, recovered cells are often heterogeneous because of mixed mod...
Analysis of vapor cloud explosion behavior in LPG spherical tanks using multi-energy modeling and machine-learning-based factor assessment
Vapor cloud explosions (VCEs) associated with liquefied petroleum gas (LPG) storage systems represent a significant hazard in refinery operations. Accurate estimation of explosion distance is essentia...
Pharmacist-led educational intervention to improve knowledge, medication adherence, and asthma control among asthma patients at Ayder Comprehensive Specialized Hospital: A protocol for randomized controlled trial
Objective To evaluate the effect of a pharmacist‑led educational intervention on medication knowledge, adherence, and asthma control among adult asthma patients at Ayder Comprehens...
Waist circumference versus BMI: A cross-sectional study comparing Cardiometabolic Risk association in the Nepalese Population
Background Obesity is a major cardiometabolic risk factor. Although body mass index (BMI) and waist circumference (WC) are established predictors of cardiometabolic risk, their pre...