PLoS ONE
Articles in this Issue
Gene expression profiling of recipient immune cells induced by 7 × 19 CAR-T cell dosing in a syngeneic mouse model
Chimeric antigen receptor (CAR)-T cell therapy is effective for hematologic malignancies; however, the response of solid tumors is limited because of the immunosuppressive tumor microenvironment, anti...
Governing digital misinformation: A computational analysis of platform intervention using a three-party evolutionary game model
The proliferation of misinformation on short video platforms poses a significant challenge to digital governance and public trust. While platforms are central actors, their strategic role in rumor gov...
Epidemiology and determinants of dyslipidemia in Iranian population: Results from the PERSIAN cohort
Background Dyslipidemia is one of the main risk factors for cardiovascular diseases worldwide. The current study aimed to determine the prevalence and correlates of dyslipidemia in...
An evaluation of strategies commonly used by health advocate programs
Many non-urgent and routine medical procedures, such as MRI and CT Scans, are performed under standardized industry protocols with minimal process variations. However, large price variations exist amo...
MMFNet: A multi-branch multi-scale framework with adaptive sparse self-attention and cross-modal fusion for sleep stage assessment
Accurate sleep stage classification serves as a crucial foundation for sleep health assessment and disease diagnosis. However, existing approaches still encounter several challenges, including limited...
Development and initial validation of a computerized adaptive test prototype for ECG interpretation using item response theory
Aims Accurate electrocardiogram (ECG) interpretation is essential for appropriate clinical decision-making, yet competency remains suboptimal among many healthcare professionals. A...
Surveillance of hepatocellular carcinoma (HCC) patients using Protein Induced by Vitamin K (PIVKA-II): A cost-utility analysis for Hong Kong
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in Hong Kong. Common risk factors include chronic hepatitis B (CHB) infection and/ o...
Sampling bias and uneven data coverage shape observed biodiversity patterns in a megadiverse island archipelago hotspot
Where and how species are sampled can shape biodiversity knowledge, spatial patterns, and data-driven conservation. In megadiverse regions of the Global South, sampling remains uneven, and available d...
Agricultural land degradation consequences as a migration driver in Egypt
Environmental migration is a global phenomenon in which increasing soil salinity reduces productivity and income, thereby increasing migration intention (MI) in affected regions. This study investigat...
PsiAudit: An open-source toolkit for auditing symmetry-organised complexity in equivariant quantum neural networks
Parameterised quantum circuits are commonly assessed using measures such as expressibility, gradient behaviour, and entanglement. While useful, these measures do not indicate whether a circuit respect...
Content validity of the quality of dying and death questionnaire- revised global-version in North American inpatient hospices
Context Enhancing end-of-life care requires valid measurement of the quality of dying and death, but existing measures of this outcome have limited applicability across varied cult...
Long-term medical and surgical treatment patterns in Korean patients newly diagnosed with primary open-angle glaucoma: A 10-year retrospective cohort study
Purpose To investigate the long-term medical and surgical treatment of patients with primary open-angle glaucoma (POAG). M...
Prevalence and factors associated with treatment delay among colorectal cancer patients at Mulago National Referral Hospital and the Uganda Cancer Institute: A cross-sectional study
Background Colorectal cancer (CRC) is an important cause of morbidity and mortality in Uganda. Timely treatment initiation is critical for outcomes, yet delays are common. This stu...
Geographic inequalities in HIV testing uptake among young women in sub-Saharan Africa: A hierarchical bayesian spatial analysis
Background Despite the high prevalence of HIV infection among young women in sub-Saharan Africa (SSA), the adoption of HIV testing and...
Glycaemic, cardiorenal, and lipid parameters associated with SGLT2 inhibitors use in Indonesian patients with type 2 diabetes: 12-month multicenter real-world study
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have demonstrated efficacy in glycaemic control and cardiorenal protection across multiple meta-analyses. However, th...
Comparative evaluation of root canal obturation techniques and sealers in Diabetic Dentin: An in-vitro push-out bond strength test
This study evaluated the comparative performance of different root canal obturation approaches using different sealing materials on the push-out bond strength of dentin samples obtained from patients...
Association of uric acid and red blood cell distribution width with severe obstructive sleep apnea–hypopnea syndrome in middle-aged males
Background Obstructive sleep apnea-hypopnea syndrome (OSAHS) is sleep-related breathing disorder with high prevalence. Polysomnography is the gold diagnosis standard. Routine clini...
Adolescent cognitive function and risk of gestational diabetes mellitus: A retrospective population-based cohort study
Background Gestational diabetes mellitus (GDM) is increasingly prevalent and linked with adverse maternal and neonatal outcomes. Low cognitive function in youth has been associated...
Evaluating the effect of bilateral transcutaneous auricular vagus nerve stimulation on motor function recovery after stroke: A multicenter, randomized controlled trial protocol
Introduction Previous studies have demonstrated that vagus nerve stimulation (VNS) is an emerging approach for stroke rehabilitation and numerous studies have shown that VNS can pr...
Renal and endothelial biomarkers in Chagas disease in the Brazilian Amazon region: Early indicators of kidney injury and disease progression
Chagas disease (CD) has impact on Amazon public health, where oral transmission is frequently related to acute cases. This peculiarity influences clinical severity and immunological responses, highlig...
Design of a high-efficiency brushless wound rotor synchronous machine with reduced torque ripple employing a novel stator winding scheme
This paper presents a novel configuration of a brushless wound rotor synchronous machine (BLWRSM). In the proposed configuration, the stator incorporates a specially designed winding having two series...
Effects of artificially increased activation of the gluteus medius on ipsilateral lower limb muscles force during gait
Background Functional Electrical Stimulation is widely used in rehabilitation to improve muscle function in individuals with neurological impairments. The gluteus medius muscle pla...
Experimental and numerical investigation on micro-motion characteristics of lightweight spacecraft
Accurate prediction of micro-motion characteristics is essential to the success of space mission operations. In this paper, the lightweight spacecraft is selected as the research object. Firstly, the...
Modification and validation of the InVEST erosion model for application at a national scale
Soil erosion is an important ecological impact of human activities such as agriculture, and models can aid in identifying areas most at risk. However, to aid targeting of actions, predictions must sim...
Agentic AI-enhanced digital twins for Smart City civil infrastructure: A secure, autonomous and auditable management framework
Smart city implementation increasingly relies on sensing and analytics; however, a persistent operational gap remains between anomaly detection and safe, timely, and accountable intervention in civil...