PLoS ONE
Articles in this Issue
Defining the link between peripheral neuronal activity and neuropathic pain: observational study protocol to investigate in vivo neurophysiological properties of nociceptors in patients with chronic neuropathic pain
Introduction Neuropathic pain affects up to 10% of the population and remains difficult to diagnose and treat effectively. Peripheral nociceptor hyperexcitability is thought to dri...
Epidemiological and genomic analysis of the dengue virus isolate from Jeddah, Saudi Arabia: Implications for future therapeutic development
Background Dengue fever is one of the major mosquito-borne diseases worldwide, and studies have shown that more than half of the world population could be at risk of dengue in the...
Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model
Changes in vocal pitch, loudness, and timing are prevalent in Parkinson’s Disease (PD) and a target for early intervention and treatment. The neural mechanisms underlying these impairments are not und...
Routine milk records reveal novel two-way interactions shaping ketosis risk in German dairy cows
Ketosis is one of the most prevalent metabolic disorders in dairy herds, with significant economic and welfare implications. However, existing literature often examines risk predictors in isolation, a...
Sustainability of affordable housing programs in Kenya: A case of Meru and Embu Counties
Amid rising urbanization and population growth, Kenya faces a critical housing shortage that disproportionately affects low- and middle-income populations. In response, the government launched the Aff...
Stakeholders’ discourse on generative AI in higher education: Insights from topic modeling and sentiment analysis
Owing to their remarkable proficiency in academic tasks, generative AI (GenAI) systems have been widely embraced in the education sector, stimulating debate among academics about their opportunities a...
Bangla validation of the smartphone addiction scale and the academic underachievement scale: The associative role of classroom mindful attention in the relationship between smartphone addiction and underachievement among adolescents and young adults
This study aimed to validate the Smartphone Addiction Scale–Short Version (SAS-SV) and the Perceived Academic Underachievement Scale (PAUS) for Bangladeshi adolescents and young adults. In addition, t...
Editorial Note: In Vitro and In Vivo Antitumor Activity of [Pt(O,O′-acac)(γ-acac)(DMS)] in Malignant Pleural Mesothelioma
Expression of Concern: Multiobjective intuitionistic fuzzy programming under pessimistic and optimistic applications in multivariate stratified sample allocation problems
Unraveling dynamic factors in Dialectic Behavioural Treatment for Adolescents (DBT-A): A study protocol
Dialectical Behavioural Therapy for Adolescents (DBT-A) is an effective treatment for adolescents exhibiting features of borderline personality disorder (BPD). However, some do not benefit, potentiall...
Temporal evolution of carbon footprint and emission reduction pathways of major crops in Inner mongolia under China’s dual-carbon goals
As an important grain-producing region in northern China, the Inner Mongolia Autonomous Region is characterized by arid and semi-arid agricultural ecosystems, limited water resources, and relatively h...
Helikite aerial sensing system: An innovative approach for monitoring construction sites
This study proposes an innovative Helikite-based aerial sensing system as a reliable aerial monitoring solution for construction sites. Construction site monitoring requires real-time, unobstructed, a...
12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung’s disease
Purpose Hirschsprung-associated enterocolitis remains a major postoperative complication of Hirschsprung’s disease (HD), and impaired epithelial barrier integrity has been proposed...
Synchronous brain activity in newborn infants and their mothers during parent-led multimodal pain alleviation with skin-to-skin contact, breastfeeding and lullaby singing: Study protocol for a fNIRS hyperscanning study
Protecting infants’ vulnerable brain during repeated painful procedures like blood-sampling and immunizations in early life is a top priority in neonatal health care. Use of parent-delivered pain mana...
Mucin expression in pancreatic ductal adenocarcinoma cell lines in 2D and 3D cultures: A proteomic and immunocytochemical analysis
Pancreatic ductal adenocarcinoma (PDAC) exhibits diverse phenotypes, including epithelial and mesenchymal characteristics, yet these features have not been effectively translated into clinical applica...
Behavior of wild tigers in captivity at the Central Zoo, Nepal
The majority of tigers ( Panthera tigris ) maintained at the Central Zoo in Jawalakhel, Nepal represents rescues resulting from human-wildlife conflict situatio...
Construction of MUC2 promoter-type periodontitis DNA vaccine candidate plasmid and preliminary exploration of the effect of Lactobacillus rhamnosus on its expression
Background Conventional cytomegalovirus (CMV) promoter-type periodontitis vaccines can offer protection against periodontitis; however, their antigen genes can be widely expressed...
Development and validation of the AI literacy, risk perception, and academic confidence questionnaire for Chinese pre-service teachers
Artificial intelligence (AI) is becoming increasingly relevant to teacher education, yet evidence remains limited on how pre-service teachers’ AI literacy, risk perception, and academic confidence can...
Robust design of LAMP assays for in-field detection of major bacterial vascular diseases of banana
Bacterial diseases of banana are a growing global threat, causing yield losses and increased management costs. Major diseases include Moko, banana blood disease (BBD), and banana Xanthomonas wilt (BXW...
Association between glycemic control and chronic kidney disease development in older patients with type 2 diabetes: A retrospective cohort study
Background In older patients with type 2 diabetes (T2D), physicians often de-emphasize strict glycemic control to avoid severe hypoglycemia. However, the incidence of renal impairm...
Can a history of crop rotations improve the prediction of soil organic carbon in the Andes? integrating machine learning multi-annual crop classification as a proxy of soil management
Soil organic carbon (SOC) is a crucial component related to various processes that ensure soil health and function. Its modeling is vital for assessing and monitoring soil degradation caused by the po...
Resource optimization algorithm for RF-aided NOMA VLC network joint blocklength control and power allocation
To achieve high-reliability in the Industrial Internet of Things (IIoT) and satisfy the low-latency requirements of industrial equipment, this paper proposes a resource optimization scheme that jointl...
Exploring the feasibility and acceptability of Continuous Glucose Monitoring among people with type 1 diabetes and healthcare providers in South Africa’s public sector: A qualitative study
Background Continuous Glucose Monitoring (CGM) is an advancement in diabetes management, offering real-time insights into blood glucose levels and facilitating decision-making arou...
Exploring DNA methylation profiles in the pathogenesis of human osteoporosis via whole-genome bisulfite sequencing
Osteoporosis is a widespread metabolic bone disorder characterized by diminished bone mass, deteriorated microarchitecture, and increased bone fragility, resulting in elevated fracture risk. This cond...
Structure function relationships differ between optic neuritis and glaucoma with comparable optical coherence tomography findings
This retrospective study compared structure-function relationships between patients with optic neuritis (ON) and primary open-angle glaucoma (POAG), focusing on the extent of retinal nerve fiber layer...