PLoS ONE
Articles in this Issue
A pilot trial investigating feasibility and preliminary efficacy of a task-specific step training regimen to improve balance recovery among community-dwelling older adults
While a growing number of studies have shown positive effects of perturbation-based balance training on balance recovery after tripping, this training has employed specialized equipment that may pose...
The quantitative proteomics analysis of multi-stage gastric mucosal lesions associated with Helicobacter pylori infection
Background Helicobacter pylori ( H. pylori ) infection is the principal etiological factor...
Frontal brain activity assessment during basic life support skill acquisition and transfer in serious game based learning environments
Basic Life Support (BLS) is a crucial life-saving skill, and the effectiveness of different training methods for acquiring and transferring BLS knowledge and skills remains an important area of invest...
Implementation, enforcement, and monitoring of tobacco advertising, promotion, and sponsorship (TAPS) laws in Ethiopia: Insights from a qualitative study
Background Tobacco advertising and promotion remain major drivers of tobacco use, particularly at points of sale (PoS). Ethiopia has enacted comprehensive tobacco control laws, inc...
The quality of care for type 2 diabetes mellitus management in Malaysian primary health care settings: A scoping review of ABC (glycated haemoglobin A1c, blood pressure, and LDL-cholesterol)
Background Diabetes is a major health concern in Malaysia, yet no comprehensive review has assessed the quality of care for these patients. This study aims to systematically review...
From theory to practice: A case study on estimating the costs of improving animal welfare on Simmental alpine dairy farms
This case study estimates the economic implications of enhancing animal welfare (AW) in Alpine dairy farming, specifically focusing on Simmental cattle in both conventional (CON) and organic (ORG) far...
Molecular analysis and computational modeling reveal temporally separable responses triggered by DENV-induced soluble factors in endothelial cells
Dengue virus (DENV) represents a growing global health challenge with billions of people at risk. Severe Dengue (SD), a complication of DENV infection that involves generalized hemorrhage, is driven,...
Isolation and characterization of Candida metapsilosis from foci of chronic pododermatitis in captive steppe eagles in Kazakhstan
Pododermatitis (bumblefoot) is a chronic, debilitating disease of the plantar surface of the foot that affects birds of prey kept in captivity worldwide. Although bacterial pathogens, especially...
Integrated transcriptomic analysis of LMB2-induced podocyte injury identifies conserved inflammatory and adaptive stress responses
Podocyte injury is a central driver of progressive glomerular diseases, yet the temporal organization of podocyte-intrinsic responses remains incompletely defined. In this study, we performed an integ...
Testing standards for AI-based scores in automated essay scoring
Recent developments in the field of artificial intelligence and machine learning allow the wide application of large language models for the evaluation of written text and other non-numerical data. Wh...
Barriers and levers to using an app for motor function assessment by therapists in hospitals: A qualitative study of the MFM-Play app
Background The Motor Function Measure (MFM) is an important evaluation tool used to monitor the progression of most neuromuscular diseases. However, the MFM is subject to inter-rat...
Herbal medicine use disclosure, database-flagged potential herb-drug interactions, and inter – interaction database concordance among patients with non-communicable diseases in Vietnam: A multicenter cross-sectional study
Background The widespread use of herbal medicines in clinical practice, particularly in Southeast Asia, presents significant challenges for medication safety management, notably re...
Urate dysregulation (hyperuricemia and gout) among people living with HIV: A protocol for a systematic review and meta-analysis
Introduction Approximately 39.9 million people are living with HIV worldwide, most in sub-Saharan Africa. Effective antiretroviral therapy has shifted attention to metabolic comorb...
Simulation study on matrix acidification of heterogeneous reservoirs based on seepage-acid etching coupled discrete virtual internal bond
Matrix acidification is one of the important means for carbonate reservoir modification and permeability increase, and the growth behavior of wormhole determines the effect of matrix acidification. In...
Association of urate-lowering therapies with abdominal aortic aneurysm growth and clinical events in men: A population-based cohort study
Objective Abdominal aortic aneurysms (AAA) are potentially life-threatening if they rupture. Xanthine oxidase inhibitors have been suggested to reduce aneurysm growth via urate-low...
Cardiovascular adjustments during experimentally induced retraction and locomotion in the invasive terrestrial snail Cornu aspersum (Müller, 1774)
The coupled function of physiology and behavior is crucial for generating survival responses. Generally, the cardiovascular system undergoes rapid adjustments during scape behavior to increase oxygen...
Deep learning architectures for EEG-based classification of Dravet syndrome: A comparative study of pre-trained and non-pretrained hybrid CNN-LSTM models
Objective This study explores the potential of artificial intelligence (AI) using a hybrid deep learning Convolutional Neural Network–Long Short-Term Memory (CNN-LSTM) framework, f...
Global, Regional, and National Burden of chronic kidney disease in older adults from 1990 to 2021: Results from the Global Burden of Disease Study 2021
Background Drawing on data from the Global Burden of Disease (GBD) 2021 study, this research provides the first systematic assessment of the burden and trends of chronic kidney dis...
Cognitive-behavioral therapy focused on inhibitory learning, for adults with avoidant/restrictive food intake disorder (ARFID): Study protocol of a prospective study
Objective Currently, there are no evidence-based treatments available for adults with avoidant/restrictive food intake disorder (ARFID). The present paper describes the design of a...
Correction: Exploring motor variability in adults with severe athetoid or ataxic cerebral palsy: Impact on error-based and reward-based learning
Personality traits have an effect on pain-related psychological variables in patients with chronic low back pain
Introduction An association between personality factors and pain experience has been investigated. However, the direct contributions of personality traits by the Maudsley Personali...
Mixed feelings: Unintended consequences of HIV outreach care in Zimbabwe
Background Decentralization of antiretroviral therapy (ART) brought treatment to millions of people in Sub-Saharan Africa. However, the implications of such decentralization are st...
Association between COMISA and cardiovascular disease: Evidence from the TURKAPNE registry
Background Comorbid insomnia and obstructive sleep apnea (COMISA) is increasingly recognized as a distinct clinical entity, yet its relationship with cardiovascular disease (CVD) r...
Development and preliminary experimental evaluation of a venturi-based slurry jet erosion test rig for comparative study of ductile and brittle materials
Slurry erosion significantly affects the durability of fluid-handling components in hydroelectric, mining, petroleum, and chemical industries. This study presents the design and preliminary laboratory...
Crystal structure of a closed ternary complex of a HNA Reverse Transcriptase in complex with a HNA/DNA duplex
1,5-Anhydrohexitol nucleic acid (HNA) is a promising xeno nucleic acid (XNA) for applications such as aptamers and catalysts, due to its favourable physico-chemical properties. Realizing this potentia...