PLoS ONE
Articles in this Issue
Research on incentive mechanisms for veterans’ participation in grassroots governance: An analysis based on behavioral expectations
Under the modernization of grassroots governance, veterans constitute a high-quality human resource for enhancing grassroots social governance capacity. Drawing on questionnaire survey data from 525 v...
TNF-α exacerbates postoperative plantar pain by regulating the expression of Nav1.8
Postoperative pain (POP) is one of the most common complications of surgical procedures. Using a rat plantar incision model, we investigated the interactions between tumor necrosis factor-α (TNF-α), n...
Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality
Background Sepsis-induced lymphopenia is associated with adverse outcomes, yet static assessments at a single time point fail to capture the clinical significance of its dynamic ev...
Porous superparamagnetic activated carbon from biomass: Adsorption behaviour and regeneration performance for 2,4-dichlorophenoxyacetic acid removal
This research used Tabebuia aurea leaves to develop a porous magnetic activated carbon (TA-MAC) that helps to remove 2,4-dichlorophenoxyacetic acid. BET analysi...
Performance, physiology, and determinants of success in IRONMAN® 70.3: A systematic review
Background IRONMAN® 70.3 events represent a rapidly expanding endurance discipline characterized by distinct physiological demands, performance determinants, and race-specific risk...
Do common dopaminergic variants modulate processing speed in cognitive aging? A longitudinal candidate gene study
Amid a global shift toward older populations, understanding the mechanisms of cognitive aging is a public health priority. Processing speed shows age-related decline and predicts dementia risk. Neuroi...
A hybrid deep learning model for user story effort estimation
Accurate effort estimation of user stories is a key challenge in agile software development due to both subjectivity and the complexity of natural language requirements. This paper proposes a hybrid D...
The epistemic advantages of representative deliberation
It is widely thought that deliberative quality improves with the number of participants: the more voices in the room, the better the collective judgment. This “wisdom of the crowds” intuition suggests...
SPPIPred: Stacking-based ensemble learning model for identification of protein-protein interaction
Protein-protein interactions (PPIs) are essential for various biological functions and are crucial in drug discovery, signaling pathways, and network reconstruction. This study presents SPPIPred, an a...
Difference in excess mortality during the COVID-19 pandemic depending on marital status in Japan
Differences in excess mortality during the coronavirus disease 2019 pandemic across marital statuses in Japan were investigated using data from across the country. Mortality data from the Vital Statis...
Reliability, construct validity, and usefulness of an assessment device for agility and motor-cognitive reactive stepping performance in community-dwelling older adults
Age-related cognitive and motor decline impairs daily functioning and increases fall risk. Although both domains interact in everyday activities, they are often assessed separately, limiting ecologica...
Inhibitory effect of 17β-estradiol on the THIK-1 channel
A two-pore domain K + (K2P) channel, THIK-1, plays important roles in microglia and macrophage. THIK-1 is known to be activated by arachidonic acid and G protei...
Prognostic impact of shock at ICU admission in acute respiratory failure
Background Acute respiratory failure (ARF) is a leading cause of intensive care unit (ICU) admission and is frequently complicated by shock. However, the prognostic significance of...
Therapeutic efficacy of artemether-lumefantrine plus single low dose primaquine for the treatment of uncomplicated Plasmodium falciparum malaria in a high transmission setting, Western Ethiopia
Background The development and spread of drug-resistant parasites continue to threaten progress toward malaria elimination. Therapeutic efficacy and molecula...
Exploring administrative staff’s acceptance of generative AI in Chinese vocational colleges: A UTAUT-guided thematic study
As Generative Artificial Intelligence (GenAI) technologies reshape institutional processes, higher vocational colleges are increasingly exploring their potential in administrative management. Guided b...
Organisational scale and fraud volatility: An exploratory agent-based simulation of occupational fraud dynamics
Fraud is commonly studied as an individual-level phenomenon. Less attention has been given to how fraud behaves at the level of organisational systems. Empirical research on the relationship between o...
Exploration of neuropeptides to identify potential target for regulating feeding behavior and development in Eurygaster integriceps
Neuropeptides regulate diverse physiological processes in insects, including feeding, reproduction, and development, and have therefore emerged as promising species-specific targets for next-generatio...
Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data
We introduce a novel parameter estimation framework for a slow-fast neuronal model using DC-coupled electrophysiological data recorded from the WAG-Rij rat model of generalised seizures. In this anima...
Experimental and numerical investigation of the mechanical performance of natural–synthetic hybrid composite laminates
Fiber-reinforced polymer composites have attracted considerable attention in engineering applications owing to their high strength-to-weight ratio, corrosion resistance, and tailorable mechanical prop...
A novel dynamic Optuna hybrid Harris Hawks Optimization approach for classification of CAD
Coronary Artery Disease (CAD) is a leading cause of mortality worldwide and is primarily associated with atherosclerotic plaque formation, resulting in coronary artery stenosis. The accurate predictio...
Pacing strategy patterns and performance outcomes in marathon running: A large-scale analysis of split time data
Although pacing strategy is widely recognized as critical for marathon performance, the actual distribution of pacing patterns among recreational runners and their associations with finish time across...
N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C
Levacetylleucine (Aqneursa™), an acetylated derivative and pro-drug of L-leucine, is the only FDA-approved monotherapy for Niemann–Pick disease type C (NPC). Its acetyl group enables transport via mon...
Positive mental attitude and depressive symptoms among medical students and residents: a cross-sectional study
Background Depression is highly prevalent among medical trainees and negatively affects academic performance, empathy, and patient care. While healthy lifestyle behaviors are known...
Malnutrition in maintenance hemodialysis: Prevalence, patterns, and clinical implications in Bangladesh
Malnutrition is a major clinical challenge among individuals receiving maintenance hemodialysis (HD), contributing to increased complications and reduced survival. The burden is particularly pronounce...
Between neuroaffirmation and access: Parents’ experiences of autism caregiving in England
Despite growing recognition of the challenges faced by families of autistic children in the United Kingdom, existing research has largely focused on parental stress and individual burden, with compara...