PLoS ONE
Articles in this Issue
Dietitian-led intervention to manage constipation in Parkinson’s disease: Study protocol for a parallel-group randomized controlled trial (NUTRI-GUT-PD)
Background Constipation is a frequent non-motor symptom in Parkinson’s Disease (PD). Standard care includes dietary and lifestyle guidance or the use of laxatives. Diet represents...
A systems biology approach to find representative genes in Acute Myeloid Leukemia
In this study, we modeled gene expression profile data from Acute Myeloid Leukemia (AML) and healthy cases. At first, the GEO-GSE9476 dataset was processed, and a total of 341 genes were identified as...
Choroidal metastasis: Impact of primary tumors and age on survival - a single center analysis
Purpose The purpose of this study was to determine whether patient’s age and their primary tumor type act as independent predictors of their survival after a diagnosis of choroidal...
The economic burden of Type 2 Diabetes by social determinants of health: A systematic review
Background The unequal distribution of resources in society generates social gradients that translate into health inequalities and differential use of health care resources and the...
Prevalence, risk factors, and management practices of premenstrual syndrome among female university students in Lebanon: An observational cross-sectional study
Background Premenstrual syndrome (PMS) is common among women of reproductive age and may impair quality of life, academic performance, and social functioning. In Lebanon, data on P...
Vehicle routing optimization and algorithms for instant delivery under customer loss mechanism
In the field of instant delivery, the mismatch between delivery resources and customer demands has led to increasingly significant customer losses. To address this issue, this study introduces the cus...
Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis
Influenza, an acute respiratory infectious disease caused by the influenza virus, remains a significant challenge for prevention and treatment due to rapid viral mutation and high pathogenicity. Tradi...
A standardized imaging and analysis workflow for quantitative evaluation of cutaneous neurofibromas in Nf1-KO mice
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder in which cutaneous neurofibromas (cNFs) represent one of the most common and burdensome manifestations. No approved pharmacological tre...
An automated approach to extracting head and brain circumference from MRI datasets
Head circumference is a fundamental biometric parameter for brain growth in both the clinical pediatric setting and in developmental neuroscience. However, the gold standard for obtaining head circumf...
Intrathecal pump refills at home or at the hospital: Protocol for a randomized controlled crossover trial—The IMPROVE study
Background Intrathecal drug delivery (IDD) offers a therapeutic option for patients suffering from refractory pain or severe spasticity. By allowing targeted and continuous infusio...
Editorial Note: A risk-averse sustainable perishable food supply chain considering production and delivery times with real-world application
Enhancing missense variant classification in predicted intrinsically disordered regions
Classifying disease-causing missense variants in intrinsically disordered regions (IDRs) remains a significant challenge, with over 25% of known deleterious variants occurring in these regions. Existi...
Identifying cluster profiles based on barriers and facilitators to physical activity during COVID-19 confinement: A cross-sectional study using machine learning analysis
Social restrictions, such as confinement periods, tend to reduce physical activity (PA) levels. However, sociodemographic factors may influence specific barriers and facilitators to PA during such per...
Age-stratified prognostic performance of hematologic inflammatory indices for 30-day mortality in emergency department patients with PCR-confirmed COVID-19: A cohort study from the pre-vaccination pandemic era
Background During the pandemic era, rapid and accessible prognostic tools were essential to support clinical decision-making for emergency department (ED) patients presenting with...
Understanding support needs of African and African-Caribbean people living with dementia, their care partners and families, and impacts of delayed support: Identifying inclusive strategies to facilitate social care support: A study protocol
African and African-Caribbean (AAC) people living with dementia (PLWD) are a population at high risk of inequitable access to health and social care services, and have poor health and wellbeing outcom...
Population genomics of Nigerian goat breeds and neighbouring populations in the West Africa–Cameroon transboundary livestock corridor
Indigenous goats in Nigeria and neighbouring countries support livelihoods across forest–savanna–Sahel environments, yet genomic structure, connectivity history, and adaptive signals are rarely invest...
Image-based identification and DEA-based optimization modeling of antibiotic packaging using unsupervised learning techniques
Background Ensuring medication safety requires accurate identification of antibiotic packaging, especially within pharmacy automation and dispensing systems. Advanced imaging and m...
Mission imputable: Effects of missing data processing on infectious disease detection and prognosis
Background Missing data in medical datasets poses significant challenges for developing effective AI/ML pipelines. Inaccurate imputation can lead to biased results, reduced model p...
Potential of Korean forest tree seed extracts as multifunctional bioresources: Evaluation of Antioxidant, anti-inflammatory, whitening, and anticancer activities
Forest tree seeds are mass produced for afforestation and forest restoration programs, but are mostly underutilized beyond propagation. Here, we aimed to evaluate the antioxidant, anti-inflammatory, a...
Retraction: Hybrid deep learning and feature selection approach for autism detection from rs-fMRI data
Risk factors for decline in estimated glomerular filtration rate amongst Malawian adults living in rural Karonga: Protocol for a prospective cohort study using cystatin C- and creatinine-based eGFR
Background The global burden of chronic kidney disease (CKD) is rising, disproportionately impacting on low- and middle-income countries. In African populations, use of serum creat...
Implementation and acceptability of high efficiency particulate air filters to reduce respiratory infections in care homes: Process evaluation of the AFRI-c cluster randomised controlled trial
Respiratory infections are easily transmitted within care homes. Within a clinical trial (called AFRI-c), which tested the effectiveness of high-efficiency-particulate-air (HEPA) filters to reduce res...
Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelination
Myelination, driven by differentiation of oligodendrocyte precursor cells, is critical for metabolic and structural support and efficient axonal signal transmission in neurons. Loss of myelin is a hal...
Dual-input deep learning system for microbial identification from blood agar plates
Objective The morphological classification of microbial cultures and colonies requires specialized knowledge and experience; therefore, automation in this field remains limited. Th...